找到约 52 条 “UKI-1” 相关结果 （用时 0.133 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M9255
|
UKI-1 | UKI-1 | Serine/Threonine Protease |
| UKI-1是一种新型的尿激酶型纤溶酶原激活剂的合成抑制剂，可以抑制癌细胞的侵袭能力（Ki=0.41 μM）。 | |||
| M9366
|
Recombinant Human IL-12 (HEK293) | 重组人白介素12 (HEK293) | Recombinant Proteins |
| Interleukin 12; IL12 | |||
| 重组人白介素12（Recombinant Human IL-12）也称之为NK细胞刺激因子（NKSF）或者杀伤性淋巴细胞成熟因子（CLMF），它是一种多效细胞因子，最初是在人成熟的B淋巴样细胞系中鉴定的。 | |||
| M9368
|
Recombinant Human IL-18 Protein (E.coli) | 重组人IL-18蛋白 (E.coli) | Recombinant Proteins |
| Interleukin18 | |||
| 重组人白介素18（Recombinant Human IL-18）又被称之为γ-干扰素诱导因子，是一种炎性细胞因子，属于白介素1家族，可以由巨噬细胞和其他细胞产生。 | |||
| M9369
|
Recombinant Human IL-21 (CHO-expressed) | 重组人白介素21 | Recombinant Proteins |
| Interleukin 21、rhIL-21 | |||
| 重组人白介素21（Recombinant Human IL-21）是一种由应答抗原刺激CD4+ T细胞产生的多效性细胞因子，能提高免疫细胞的抗原特异性反应。 | |||
| M9980
|
Recombinant Human IL-10 Protein (HEK 293) | 重组人IL-10蛋白 (HEK 293) | Recombinant Proteins |
| Interleukin-10 | |||
| 重组人IL-10蛋白（Recombinant Human IL-10 Protein）是多种哺乳动物细胞类型产生的免疫抑制细胞因子，包括巨噬细胞、单核细胞、T细胞、B细胞和角质形成细胞。 | |||
| M9982
|
Recombinant Human IL-13 Protein (HEK293, C-His) | 重组人IL-13蛋白 (HEK293, C-His) | Recombinant Proteins |
| Interleukin-13; rhIL-13 | |||
| 重组人IL-13蛋白（Recombinant Human IL-13 Protein）是一种免疫调节细胞因子，主要由活化的Th2细胞、肥大细胞和NK细胞产生。 | |||
| M9983
|
Recombinant Human IL-36RA Protein (HEK293, C-His) | 重组人IL-36RA蛋白 (HEK293, C-His) | Recombinant Proteins |
| Interleukin-36RA; IL-1F5 | |||
| 重组人IL-36RA蛋白（rhIL-36RA）原名 rhIL-1F5，可通过与 IL-1Rrp2 受体结合，拮抗 IL-36α，β或γ诱导的 NF-RrpB 信号传导，从而阻止功能信号的启动。 | |||
M10139
|
Anakinra | 阿那白滞素 | IL Receptor/Related |
| Raleukin; AMG-719 | |||
| Anakinra（Raleukin）是一种重组的白细胞介素-1受体（IL-1R）的拮抗剂，用于阻断促炎作用，可用于骨关节炎（OA）的相关研究。 | |||
| M10536
|
Recombinant Human Interleukin-31 (E. coli) | 重组人IL-31蛋白（E. coli） | Recombinant Proteins |
| rHuIL-31 | |||
| 重组人白细胞介素-31 (IL-31)信号通过IL-31受体A和抑癌素M受体亚基，通过受体激活STAT3，并可能参与皮肤免疫。 | |||
| M15036
|
Recombinant Human IL-8/CXCL8 (77aa, E. coli) | 重组人IL-8/CXCL8蛋白 (77aa, E. coli) | Recombinant Proteins |
| Interleukin-8; GCP-1; NAP-1; MDNCF | |||
| 白细胞介素-8 (IL-8)又称CXCL8、GCP-1和NAP-1，是最早发现的趋化因子之一，属于CXCL家族，其中前两个保守半胱氨酸被一个残基分离。 | |||
| M40921
|
Recombinant Human IL-1β Protein (CHO) | 重组人IL-1β蛋白 (CHO) | Recombinant Proteins |
| IL1-BETA; IL1F2; interleukin 1 beta | |||
| Interleukin 1 beta (IL-1β) is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. | |||
| M15109
|
Recombinant Mouse IL-10 (CHO) | 重组小鼠IL-10蛋白 (CHO) | Recombinant Proteins |
| Mouse Interleukin-10 Protein | |||
| 重组小鼠IL-10蛋白 (CHO) 属于 IL-10 家族，与 Epstein-Barr 病毒蛋白 BCRFI 具有 80% 以上的序列同源性。它由许多免疫细胞产生，例如 T 细胞、巨噬细胞、肥大细胞和树突状细胞。它通常以同型二聚体的形式分泌，并在与其受体结合后，抑制活化的巨噬细胞和 Th2 细胞合成多种细胞因子，包括 IFN-γ、IL-2、IL-3、TNF 和 GM-CSF。 | |||
| M21094
|
Recombinant Rat IL-1β (E. coli) | 重组大鼠 IL-1β 蛋白 (E. coli) | Recombinant Proteins |
| Interleukin-1 Beta; IL1F2 | |||
| 白细胞介素-1β（IL-1β）是一种非分泌的促炎症细胞因子，主要由活化的巨噬细胞以及中性粒细胞、上皮细胞和内皮细胞产生。通过使用小鼠 D10S 细胞进行细胞增殖测定，ED50为 < 10.0 pg/ml，相当于比活性 > 1.0 × 108 units/mg。 | |||
| M21448
|
Recombinant Mouse IL-15RA (Mammalian, C-Fc) | 重组小鼠IL-15RA 蛋白 (Mammalian, C-Fc) | Recombinant Proteins |
| Interleukin-15 receptor subunit alpha | |||
| 重组小鼠白细胞介素15受体亚基α由哺乳动物表达系统产生，编码Gly33-Lys205的目标基因在c端带有Fc标签表达。蛋白编号：Q60819。 | |||
| M21449
|
Recombinant Mouse IL-21 (E.coli, N-6His) | 重组小鼠IL-21 蛋白 (E.coli, N-6His) | Recombinant Proteins |
| Interleukin-21; IL21 | |||
| IL-21是一种细胞因子，对免疫系统的细胞有强大的调节作用，包括自然杀伤（NK）细胞和细胞毒性T细胞，可以摧毁病毒感染或癌症细胞。重组小鼠白介素-21由大肠杆菌表达系统产生，表达编码Pro25-Ser146的目标基因，在N端带有一个6His标签。 | |||
| M21556
|
Recombinant Human IL-17A (E.coli) | 重组人IL-17A蛋白 (E.coli) | Recombinant Proteins |
| Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8 | |||
| Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. Recombinant human interleukin 17a is produced by the Escherichia coli expression system and expresses the target gene encoding Gly24-Ala155. | |||
| M21665
|
Recombinant Mouse IL-18 (E.coli, N-6His) | 重组小鼠IL-18蛋白 (E.coli, N-6His) | Recombinant Proteins |
| Interleukin-18 | |||
| 重组小鼠白细胞介素-18（IL-18）是一种属于IL-1家族的蛋白质，IL-18与广泛表达的IL-18 R alpha结合，后者招募IL-18 R beta以形成信号受体复合物。重组小鼠白细胞介素-18由大肠杆菌表达系统生产，编码Asn36-Ser192的目标基因在N端有一个6His标签。 | |||
| M21666
|
Recombinant Mouse IL-18BPd (Mammalian, C-Fc) | 重组小鼠IL-18BPd蛋白(Mammalian, C-Fc) | Recombinant Proteins |
| Interleukin-18 Binding Protein Isoform d | |||
| 重组白细胞介素18结合蛋白（IL-18BP）是一种生理性抑制剂，通过与IL-18的受体结合部位结合而发挥作用。重组小鼠白细胞介素18结合蛋白异型d由哺乳动物表达系统生产，编码Thr29-Ala193的目标基因在C端带有人IgG1 Fc标签。 | |||
| M21705
|
Recombinant Mouse IL-17F (Mammalian, C-6His) | 重组小鼠IL-17F蛋白(Mammalian, C-6His) | Recombinant Proteins |
| Interleukin-17F | |||
| 重组小鼠 Interleukin-17F 由哺乳动物表达系统产生，编码 Arg29-Ala161 的靶基因在 C 端用 6His 标签表达。IL-17F 在活化的而非静止的 CD4+ T 细胞和活化的单核细胞中表达。IL-17F 可以刺激其他几种细胞因子的产生，包括 IL-6、IL-8 和粒细胞集落刺激因子。 | |||
| M21706
|
Recombinant Human IL-17F (Mammalian, C-6His) | 重组人IL-17F 蛋白(Mammalian, C-6His) | Recombinant Proteins |
| Interleukin-17F human | |||
| 重组人白细胞介素 17F 由哺乳动物表达系统产生，编码 Arg31-Gln163 的靶基因在 C 端用 6His 标签表达。IL-17F 可以刺激其他几种细胞因子的产生，包括 IL-6、IL-8 和粒细胞集落刺激因子。 | |||
| M21723
|
Recombinant Human IL-17F (Mammalian) | 重组人IL-17F 蛋白(Mammalian) | Recombinant Proteins |
| Interleukin-17F | |||
| 重组人白介素 17F 由哺乳动物表达系统产生，并表达编码 Arg31-Gln163 的靶基因。IL-17F 已被证明可以刺激其他几种细胞因子的产生，包括 IL-6、IL-8 和粒细胞集落刺激因子。IL-17F 可以调节软骨基质更新并刺激 PBMC 和 T 细胞增殖。ED50 为 24.21 ng/ml。 | |||
| M22510
|
Recombinant Mouse IL-1α Protein (E. coli) | 重组小鼠IL-1α (E. coli) | Recombinant Proteins |
| Interleukin-1 alpha | |||
| 白细胞介素-1 α (IL-1α) 是一种非分泌型促炎细胞因子，产生于多种细胞，包括单核细胞、组织巨噬细胞、角质形成细胞和其他上皮细胞。使用鼠 D10S 细胞通过细胞增殖测定确定的ED 50小于 2.0 pg/ml，对应于 > 5.0 × 108 IU /mg 的比活性。 | |||
| M25229 | Rilonacept | Rilonacept | IL Receptor/Related |
| Arcalyst IL 1 Trap Interleukin 1 Trap | |||
| Rilonacept (Arcalyst) 是一种二聚体融合蛋白，是一种白细胞介素 1 抑制剂。 Rilonacept 由连接到人 IgG1 的 Fc 部分的 IL-1R 组分的细胞外部分的配体结合域组成。 Rilonacept可用于cryopyrin相关周期性综合征的研究。 | |||
| M25418
|
Recombinant Mouse IL-1β (CHO) | 重组小鼠IL-1β (CHO) | Recombinant Proteins |
| interleukin 1 beta | |||
| 白介素-1β (IL-1β)是一种促炎细胞因子，产生于多种细胞，包括单核细胞、组织巨噬细胞、角化细胞和其他上皮细胞。通过使用 D10S 细胞的细胞增殖测定中测得的ED50为 < 10.0 pg/ml，对应于 > 1.0 × 108 units/mg 的比活性。 | |||
| M31112
|
Recombinant Human IL-21 Protein (E. coli) | 重组人IL-21蛋白 (E. coli) | Recombinant Proteins |
| Interleukin-21 | |||
| IL-21 is expressed by CD4+ T cells, natural killer (NK) T cells, and Th17 cells. IL-21 plays a pivotal role in the survival and proliferation of B cells, and their differentiation to immunoglobulin (Ig) producing cells. | |||
| M40608
|
Recombinant Human IL18R1 (Mammalian, C-6His) | 重组人IL18R1 (Mammalian, C-6His) | Recombinant Proteins |
| Interleukin-18 receptor 1; IL-18R-alpha | |||
| The interleukin 18 receptor 1 (IL18R1) belongs to interleukin 1 receptor family. IL18R1 has been shown to mediate EAE through regulation of both IL-18-dependent and -independent pathways. | |||
| M40612
|
Recombinant Rat IL-4 Protein (CHO, C-His) | 重组大鼠IL-4蛋白 (CHO, C-His) | Recombinant Proteins |
| Interleukin-4; BCGF-1; B cell stimulatory factor-1 | |||
| Interleukin-4 (IL-4) is a pleiotropic cytokine regulates diverse T and B cell responses including cell proliferation, survival, and gene expression. IL-4 regulates the differentiation of native CD4+ T cells (Th0 cells) into helper Th2 cells, and regulates the immunoglobulin class switching to the IgG1 and IgE isotypes. | |||
| M40923
|
Recombinant Human IL31RA Protein (HEK293, C-His) | 重组人IL31RA蛋白 (HEK293, C-His) | Recombinant Proteins |
| interleukin 31 receptor A | |||
| The recombinant human IL31RA consists 508 amino acids and predicts a molecular mass of 58.2 kDa. A DNA sequence encoding the human IL31RA (Met1-Ser516) was expressed with a polyhistidine tag at the C-terminus. | |||
| M40924
|
Recombinant Human IL31RA Protein (HEK293, C-hFc) | 重组人IL31RA蛋白 (HEK293, C-hFc) | Recombinant Proteins |
| interleukin 31 receptor A | |||
| The recombinant human IL31RA consists 735 amino acids and predicts a molecular mass of 83.5 kDa. A DNA sequence encoding the human IL31RA (Met1-Ser516) was expressed with the Fc region of human IgG1 at the C-terminus. | |||
| M40927
|
Recombinant Mouse IL-1RL2 Protein (Mammalian, C-6His) | 重组小鼠 IL-1RL2蛋白 (Mammalian, C-6His) | Recombinant Proteins |
| Interleukin-1 Receptor-like 2; IL-36 receptor | |||
| Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene, belongs to the interleukin-1 receptor family. IL1RL2 is the receptor for interleukin-36. Recombinant Mouse Interleukin-1 Receptor-like 2 expressed the target gene encoding Asp22-Arg338(Ala158Val) with a 6His tag at the C-terminus. | |||
| M2629
|
Diacerein | 双醋瑞因 | Others |
| Diacerhein; Diacetylrhein; Fisiodar; Artrodar | |||
| Diacerin（双醋瑞因）是Interleukin-1B(IL-1B)产生的促炎性细胞因子抑制剂，可作用于酰基乙醇胺酸酰胺酶（NAAA-N），IC50为0.7μM。 | |||
| M1622
|
Secukinumab | 苏金单抗；司库奇尤单抗 | IL Receptor/Related |
| AIN457; CAS# 1229022-83-6 | |||
| Secukinumab (AIN457) 是一种首创的 (first-in-class) ，针对白细胞介素 (IL-17A) 的高亲和力人源性单克隆抗体，可用于斑块状银屑病、强直性脊柱炎和银屑病关节炎的相关研究。 | |||
| M40957
|
Recombinant Human IL-22 Protein (HEK293) | 重组人IL-22蛋白 (HEK293) | Recombinant Proteins |
| Interleukin-22 | |||
| Interleukin-22(IL-22) belongs to a group of cytokines called the IL-10 family or IL-10 superfamily. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens in epithelial cells such as those in the lung and gut. | |||
| M5002
|
4'-Chloropropiophenone | 4'-Chloropropiophenone | Others |
| 4-pyridazinecarboxamides and esters as interleukin-1beta converting enzyme inhibitors | |||
| M11359
|
Recombinant Human IL-6R (CHO) | 重组人IL-6R (CHO) | Recombinant Proteins |
| IL-6RA; IL-6R1; CD126; IL-6RA | |||
| 白细胞介素-6受体α 属于I型细胞因子受体家族。重组人Interleukin-6R（IL-6R）在含有10.0 ng/ml 人IL-6的M1细胞中，通过细胞增殖实验测得的ED50为 < 0.2 μg/ml。 | |||
| M10465
|
Recombinant Mouse Interleukin-4 (IL-4) (CHO-expressed) | 重组小鼠白细胞介素-4 | Recombinant Proteins |
| rMuIL-4 | |||
| Recombinant Mouse Interleukin-4是一种多效性细胞因子，可调节多种T和B细胞反应，包括细胞增殖、存活和基因表达。IL-4 调节天然 CD4+ T 细胞（Th0 细胞）向辅助 Th2 细胞的分化，并调节免疫球蛋白类别转换为 IgG1 和 IgE 同种型。 | |||
| M10466
|
Recombinant Mouse Interleukin-4 (IL-4) (E. coli) | 重组小鼠白细胞介素-4 (E. coli) | Recombinant Proteins |
| Recombinant Mouse Interleukin-4是一种多效性细胞因子，可调节多种T和B细胞反应，包括细胞增殖、存活和基因表达。IL-4 调节天然 CD4+ T 细胞（Th0 细胞）向辅助 Th2 细胞的分化，并调节免疫球蛋白类别转换为 IgG1 和 IgE 同种型。 | |||
| M21121
|
Recombinant Rat IL-10 (CHO) | 重组大鼠 IL-10蛋白 (CHO) | Recombinant Proteins |
| B-TCGF; CSIF; TGIF | |||
| Interleukin-10 (IL-10) 属于IL-10家族，由许多免疫细胞产生，如 T 细胞、巨噬细胞、肥大细胞和树突状细胞。它通常以同源二聚体的形式分泌，与受体结合后可抑制多种细胞因子的合成，包括活化巨噬细胞和 Th2 细胞产生的 IFN-γ、IL-2、IL-3、TNF 和 GM-CSF。 | |||
| M21402
|
Recombinant Mouse IL-27 (Mammalian, C-6His) | 重组小鼠IL-27 蛋白 (Mammalian, C-6His) | Recombinant Proteins |
| Interleukin-27 subunit alpha; IL-27 subunit alpha | |||
| IL-27 is a heterodimeric cytokine which belongs to the IL-6/IL-12 family of long type I cytokines. Recombinant Mouse Interleukin-27 Subunit Alpha and Interleukin-27 Subunit Beta expressed the target gene encoding Tyr19-Pro228&Phe29-Ser234 with a 6His tag at the C-terminus. | |||
| M24575 | Sirukumab | Sirukumab | IL Receptor/Related |
| CNTO-136; Anti-Human IL6 Recombinant Antibody | |||
| Sirukumab (CNTO-136) 是一种人源化单克隆抗 IL6 (Interleukin Related) IgG1κ 抗体。Sirukumab 具有用于活动性狼疮性肾炎研究的潜力。 | |||
| M24858 | Bempegaldesleukin | Bempegaldesleukin | IL Receptor/Related |
| NKTR-214 BEMPEG | |||
| Bempegaldesleukin (NKTR-214) 是一种聚乙二醇化白细胞介素-2 (IL-2)，是一种免疫刺激性IL-2 前体药物，可作为 CD122 优先的 IL-2 通路激动剂。Bempegaldesleukin 可以刺激抗肿瘤免疫反应。 | |||
| M24895 | Melredableukin alfa | Melredableukin alfa | IL Receptor/Related |
| RG7835; RO7049665 | |||
| Melredableukin alfa (RO-7049665) 是一种融合蛋白，由人 IgG1-κ 通过多肽连接子融合到人突变白细胞介素 2 (IL2 mutin)。Melredableukin alpha 可用于研究乙型肝炎和溃疡性结肠炎。 | |||
| M25104 | Tozorakimab | Tozorakimab | IL Receptor/Related |
| MEDI-3506 | |||
| Tozorakimab (MEDI-3506) 是一种靶向白介素-33 (interleukin-33) 的人免疫球蛋白 G1 单克隆抗体。Tozorakimab 可用于研究慢性阻塞性肺疾病。 | |||
| M25235 | Siltuximab | 司妥昔单抗 | IL Receptor/Related |
| CNTO-328 | |||
| Siltuximab（司妥昔单抗）是一种抗IL-6 (interleukin-6) 单克隆抗体，具有抗肿瘤活性，可用于多中心性巨大淋巴结增生症 (MCD) 和 COVID-19 的相关研究。 | |||
| M25262 | Ordesekimab | 奥司奇单抗 | IL Receptor/Related |
| AMG 714; PRV-015 | |||
| Ordesekimab (AMG 714; PRV-015) 是一种人 IgG1κ 抗 IL-15 (Interleukin Related) 单克隆抗体。Ordesekimab 与 IL-15 的结合抑制 IL-15 与 IL-2Rβ 和 IL-15 受体复合物的共同 γ 链的相互作用，但不与 IL-15Rα 链相互作用。Ordesekimab 具有研究无反应性乳糜泻 (NRCD) 的潜力。 | |||
| M25271 | Perakizumab | Perakizumab | IL Receptor/Related |
| RG4934; Anti-Human IL17A Recombinant Antibody | |||
| Perakizumab (RG4934) 是一种针对 IL-17A (Interleukin Related) 的人源化 IgG1κ 单克隆抗体。Perakizumab 可用于自身免疫性疾病的研究，如银屑病关节炎。 | |||
| M25282 | Anrukinzumab | Anrukinzumab | IL Receptor/Related |
| IMA-638 | |||
| Anrukinzumab (IMA-638) 是一种抑制人 IL-13 的人源化抗体。Anrukinzumab 能有效减少食蟹猕猴模型中的肺部炎症。Anrukinzumab 可用于研究溃疡性结肠炎 (UC) 以及哮喘。 | |||
| M25396
|
Recombinant Human Oncostatin M (OSM) (E. coli, 209aa) | 重组人Oncostatin M (E. coli, 209aa) | Recombinant Proteins |
| OSM | |||
| Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, which also includes IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. ED50 < 10.0 ng/ml, measured by a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 1.0 × 105 units/mg. | |||
| M25397
|
Recombinant Human Oncostatin M (OSM) (E. coli, 227aa) | 重组人Oncostatin M (E. coli, 227aa) | Recombinant Proteins |
| OSM | |||
| Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, including IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. ED50 < 10.0 ng/ml, measured by a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 1.0 × 105 units/mg. | |||
| M25440
|
Recombinant Human Osteopontin/SPP1 Protein (Mammalian, C-6His) | 重组人Osteopontin/SPP1蛋白 (Mammalian, C-6His) | Recombinant Proteins |
| OPN; Secreted Phosphoprotein 1 | |||
| Osteopontin/SPP1 is a secreted multifunctional glycoprotein. Its putative functions include roles in bone metabolism, immune regulation, wound healing, cell survival, and tumor progression. Osteopontin/SPP1 acts as a cytokine that is involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10. | |||
| M31329
|
Recombinant Mouse IL-33 Protein (E. coli, 95%) | 重组小鼠IL-33蛋白 (E. coli, 95%) | Recombinant Proteins |
| Interleukin 33 | |||
| Mouse Interleukin 33 (IL-33) may regulates gene transcription in producer cells. IL-33 induces the expression of IL-4, IL-5, IL-13 and also leads to severe pathological changes in mucosal organs. | |||
| M45121
|
Recombinant Human IL-17B (Mammalian, C-Fc) | 重组人 IL-17B (Mammalian, C-Fc) | Recombinant Proteins |
| interleukin-17 beta | |||
| Interleukin-17B (IL-17B) is a member of IL-17 cytokines family that plays important roles in host defence responses and inflammatory diseases. | |||
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