IL-21是一种细胞因子，对免疫系统的细胞有强大的调节作用，包括自然杀伤（NK）细胞和细胞毒性T细胞，可以摧毁病毒感染或癌症细胞。重组小鼠白介素-21由大肠杆菌表达系统产生，表达编码Pro25-Ser146的目标基因，在N端带有一个6His标签。
别名：Interleukin-21; IL21
Interleukin-21 (IL-21) is a approximately 14kda cytokine belonging to the IL-15/IL-21 family. IL-21 is produced by activated T follicular helper cells (Tfh), Th17 cells, and NKT cells. It plays its biological role through the heterodimer receptor complex (IL-21 specific il-21r). IL-21 is a cytokine that has a powerful regulatory effect on the cells of the immune system, including natural killer cells (NK) and cytotoxic T cells that can destroy viral infections or cancer cells. This cytokine induces cell division/proliferation in target cells. It is required for the migration of dendritic cells to draining lymph nodes, and it jointly stimulates the activation, proliferation and survival of CD8+ T cells and NKT cells, and promotes the polarization of Th17 cells. It blocks the production of regulatory T cells and its inhibitory effect on CD4+ T cells.
Accession: Q9ES17
APMol Mass: 16 KDa, reducing conditions
Endotoxin < 1 EU/µg
Lyophilized from a 0.2 μm filtered solution of 20mM Histidine-HCl, 6% Sucrose, 2% Glycine, 50mM NaCl, 0.05% Tween 80, pH 6.5.
| 性状 | Lyophilized powder |
| 溶解性（25°C） | Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| 储存条件 | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at ≤ -20°C for 3 months. |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
[1] Anusha Kalbasi, et al. Nature. Potentiating adoptive cell therapy using synthetic IL-9 receptors
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