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Recombinant Mouse IL-27 (Mammalian, C-6His) 重组小鼠IL-27 蛋白 (Mammalian, C-6His)

目录号 M21402 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


IL-27 is a heterodimeric cytokine which belongs to the IL-6/IL-12 family of long type I cytokines. Recombinant Mouse Interleukin-27 Subunit Alpha and Interleukin-27 Subunit Beta expressed the target gene encoding Tyr19-Pro228&Phe29-Ser234 with a 6His tag at the C-terminus.

Recombinant Mouse IL-27 (Mammalian, C-6His)结构式

别名:Interleukin-27 subunit alpha; IL-27 subunit alpha

规格 价格 库存状态
10ug ¥ 2700 中国库存现货
50ug ¥ 7830 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >90%, Endotoxin<1 EU/µg
  • COA
  • MSDS
生物活性

IL-27是一种异型二聚体细胞因子,属于IL-6/IL-12家族的长型I型细胞因子。它在单核细胞、内皮细胞和树突状细胞上表达。IL-27是活化的抗原呈递细胞的早期产物,驱动新生CD4(+)T细胞的快速克隆性扩张,并在Th1细胞启动的早期调节中发挥作用,驱动高效的适应性免疫反应。IL-27能增强TH1反应的早期阶段,抑制TH2和TH17的分化。它通过两种不同的途径诱导TH1细胞的分化,即p38 MAPK/TBX21和ICAM1/ITGAL/ERK依赖的途径。它还能诱导STAT1、STAT3、STAT4和STAT5的磷酸化,并通过STAT1激活TBX21/T-Bet,从而使IL12RB2上调,这是一个对TH1细胞承诺至关重要的事件。IL-27通过WSX-1/STAT1信号传导对黑色素瘤具有抗增殖活性。


Accession O35228&Q8K3I6

Endotoxin < 1 EU/µg

Apparent Molecular Weight: 50-65 KDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution of PBS, 2mM EDTA, 5% Trehalose, pH 7.4.

化学性质
性状 Lyophilized powder
溶解性(25°C) Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
储存条件 Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Andrea Nortey, et al. J Neuroinflammation. The cytokine IL-27 reduces inflammation and protects photoreceptors in a mouse model of retinal degeneration

[2] Arjun Sharma, et al. J Immunol. IL-27 Enhances γδ T Cell-Mediated Innate Resistance to Primary Hookworm Infection in the Lungs

[3] Xiaoyan Wang, et al. Cell Death Discov. Exosomes from adipose-derived mesenchymal stem cells alleviate sepsis-induced lung injury in mice by inhibiting the secretion of IL-27 in macrophages

[4] Jin-Qing Liu, et al. Am J Cancer Res. Is AAV-delivered IL-27 a potential immunotherapeutic for cancer?

[5] Shanshan Zhao, et al. J Cell Mol Med. IL-27 Rα+ cells promoted allorejection via enhancing STAT1/3/5 phosphorylation

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