Recombinant Human GDF-15 Protein (HEK293 N-hFc) 别名：Growth-differentiation factor 15; MIC-1; 重组人GDF-15 蛋白 (HEK293 N-hFc)

目录号 M58941

Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily. GDF-15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.

Recombinant Human GDF-15 Protein (HEK293 N-hFc)结构式

规格	价格	库存状态
50ug	¥ 3200	现货

本产品不参加促销活动

*AbMole所有产品仅供有资质的科研机构或医药企业进行科学研究或药证申报用途，不能被用于人体和任何其它用途。我们不向任何个人或非科研性质的机构提供产品和服务。

质量标准及产品资料

纯度：>90%, Endotoxin < 1 EU/µg
COA

化学性质/溶解性/储存

性状	Lyophilized powder
中文名称	重组人GDF-15 蛋白 (HEK293 N-hFc)
溶解性	Reconstitute the lyophilized powder in distilled water to a concentration not less than 100 μg/mL.
储存条件	Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
运输方式	冰袋运输，根据产品的不同，可能会有相应调整。

生物活性

The recombinant human GDF-15 is a disulfide-linked homodimeric protein. The reduced monomer consists of 370 amino acids and has a predicted molecular mass of 40.6 kDa. A DNA sequence encoding the mature form of human GDF15 (Ala 197-Ile 308) was expressed with the fused Fc region of human IgG1 at the N-terminus.

Immobilized Recombinant Human GFRAL Protein at 2 μg/mL (100 μL/well) can bind Recombinant Human GDF-15 Protein, the EC50 is 50-150 ng/mL.

Accession: Q99988

Apparent Molecular Weight: 44 kDa, under reducing conditions

Endotoxin < 1 EU/µg

Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5.

实验参考

动物实验

建议您制定动物给药及实验方案时，尽量参考已发表的相关实验文献（溶剂种类及配比众多，简单地溶解目的化合物，并不能解决动物给药依从性、体内生物利用度、组织分布等相关问题，未必能保证目的化合物在动物体内充分发挥生物学效用）。
体内实验的工作液，建议您现用现配，当天使用；如在配制过程中出现沉淀、析出现象，可以通过超声和（或）加热的方式助溶。
切勿一次性将产品全部溶解。