| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M6224
|
Etanercept | 依那西普 | TNF Receptor |
| Etanercept 是一种结合肿瘤坏死因子 (TNF) 的二聚体融合蛋白，作为 TNF 抑制剂。Etanercept 能竞争性地抑制 TNF-α 和 TNF-β 与细胞表面 TNF 受体的结合，使肿瘤坏死因子在生物学上失去活性。可用于骨关节炎（OA）的相关研究。 | |||
| M6223
|
Tocilizumab | 托珠单抗 | IL Receptor/Related |
| MRA; atlizumab | |||
| Tocilizumab（托珠单抗）是一种靶向IL6的人源单克隆抗体，能阻断IL-6R，并有助于在缺血性骨坏死小鼠模型中保护软骨和增加骨体积。适用于人源化、免疫缺陷型及非免疫缺陷型小鼠，同时可用于强直性脊柱炎的相关研究。MW: 148 KD。 | |||
| M6221
|
Pertuzumab | 帕妥珠单抗 | EGFR/HER2 |
| Omnitarg, 2C4 | |||
| Pertuzumab是一种人源单价克隆抗体，抑制HER2二聚化、破坏HER2与其他HER家族成员结合的能力。MW: 148 KD。（适用于人源及非人源化小鼠） | |||
| M6218
|
Trastuzumab | 曲妥珠单抗 | EGFR/HER2 |
| Herceptin | |||
| Trastuzumab是人源重组的抗体抑制剂，与HER2的胞外区域相结合。 MW:145.53 KD。（适用于人源或免疫缺陷型小鼠） | |||
| M6166
|
Bevacizumab | 贝伐单抗；贝伐珠单抗 | VEGFR/PDGFR |
| bevacizumab；Avastin | |||
| Bevacizumab (anti-VEGF, Avastin) 是一种人源化的anti-VEGF单克隆抗体，是VEGF的抑制剂。可与所有人源VEGF-A亚型（和具有生物活性的蛋白水解片段）结合、中和。MW:149 KD。 | |||
| M6101
|
Atezolizumab | 阿特珠单抗；阿替利珠单抗 | PD-1/PD-L1 |
| MPDL3280A,Anti-PD-L1；Tecentriq | |||
| Atezolizumab（阿特珠单抗，阿替利珠单抗)是一种人源化抗PD-L1单克隆抗体，它能够抑制PD-L1与PD-1及B7-1的信号传导，并恢复肿瘤特异性T细胞免疫。但不影响PD-L2与PD-1的相互作用。可用于非小细胞肺癌（NSCLC）的相关研究。MW：145 KD。Atezolizumab 能与鼠类PD-L1反应（适用于人源及非人源化小鼠）。 | |||
| M6100
|
Nivolumab | 纳武单抗；纳武利尤单抗 | PD-1/PD-L1 |
| BMS-936558, ONO-4538, MDX-1106；Opdivo | |||
| Nivolumab（纳武单抗，纳武利尤单抗）是一种完全的人源化抗PD-1的IgG4单克隆抗体。具有免疫检查点抑制活性和抗肿瘤活性；MW：143.597 KD。（适用于人源小鼠）。 | |||
| M3835
|
Alirocumab | 阿利珠单抗；阿利西尤单抗 | PCSK9 |
| REGN 727；SAR 236553 | |||
| Alirocumab是一种全人源的IgG1型PCSK9单抗，能作用于B6小鼠，可用于高胆固醇血症的研究。 | |||
| M3813
|
Avelumab (MSB0010718C) | 阿维单抗；阿维鲁单抗 | PD-1/PD-L1 |
| MSB0010718C | |||
| Avelumab 是一种独特的强ADCC活性的PD-L1全人源化抗体，能有效地阻止PD-L1与PD-1的结合。Avelumab可以识别鼠 PD-L1（对鼠类PD-L1有高亲和性和活性） | |||
| M1503
|
Panitumumab | 帕尼单抗 | EGFR/HER2 |
| ABX-EGF | |||
| Panitumumab 帕尼单抗，是第一个完全人源化 IgG2 单克隆抗体，其靶向作用于表皮生长因子受体（EGFR）。 | |||
M40939
|
Rat IgG2b Isotype Control In vivo | Rat IgG2b Isotype Control In vivo | Others |
| Rat IgG2b Isotype Control In vivo 单克隆抗体（克隆号：1-2）可与锁孔血蓝蛋白 (keyhole limpet hemocyanin, KLH) 发生反应。由于哺乳动物不表达 KLH，因此该抗体非常适合在大多数体内和体外应用中用作大鼠 IgG2b 抗体的同种型匹配对照。 | |||
| M40936
|
Anti-Mouse CD4 (Clone GK1.5) In vivo | Anti-Mouse CD4 (Clone GK1.5) In vivo | GPR/FFAR |
| Anti-Mouse CD4 (克隆号：GK1.5) 可与小鼠CD4结合反应。CD4是T细胞受体（TCR）的协同受体，有助于后续与抗原呈递细胞的交流通讯。 | |||
| M40935
|
Anti-Mouse IFNγ (interferon gamma) (Clone H22) In vivo | Anti-Mouse IFNγ (interferon gamma) (Clone H22) In vivo | Interferon-α/β/γ |
| Interferon Gamma | |||
| Anti-Mouse IFNγ (Clone H22)单克隆抗体与小鼠IFNγ(interferon gamma)反应。IFNγ是一种20 kDa的可溶性多效性细胞因子，是II型干扰素的唯一成员。 | |||
| M40934
|
Anti-Mouse CTLA-4 (Clone 9D9) In vivo | Anti-Mouse CTLA-4 (Clone 9D9) In vivo | Immunology/Inflammation |
| Cytotoxic T Lymphocyte-Associated Antigen-4 | |||
| Anti-Mouse CTLA-4 Antibody (Clone 9D9) recognizes an epitope on mouse CTLA-4. CTLA-4 is expressed on activated T and B lymphocytes. | |||
| M40918
|
Anti-Mouse Ly6G (Clone 1A8) In vivo | Anti-Mouse Ly6G (Clone 1A8) In vivo | Immunology/Inflammation |
| Anti-Mouse Ly6G antibody (Clone 1A8) In vivo recognizes an epitope on mouse Ly6G. Ly6G is expressed by neutrophils. | |||
| M40909
|
Anti-Mouse CD8a (Clone 53-6.7) In vivo | Anti-Mouse CD8a (Clone 53-6.7) In vivo | Immunology/Inflammation |
| Lyt2, Ly-2 | |||
| Anti-Mouse CD8a (Clone 53-6.7) In vivo recognizes Lyt 2. Clone 53-6.7 competes with clone 5H10-1 for binding to thymocytes. | |||
| M40856
|
Anti-Mouse CD4 (Clone YTS191) In vivo | Anti-Mouse CD4 (Clone YTS191) In vivo | GPR/FFAR |
| Anti-Mouse CD4 (Clone YTS191) In vivo 可与小鼠CD4结合反应。CD4是T细胞受体（TCR）的协同受体，有助于后续与抗原呈递细胞的交流通讯。 | |||
| M40830
|
Anti-Mouse CD3ε In vivo | Anti-Mouse CD3ε In vivo | Immunology/Inflammation |
| Anti-Mouse CD3Epsilon | |||
| Anti-Mouse CD3ε (Clone 145-2C11) In vivo单克隆抗体与小鼠CD3ε反应。小鼠CD3ε是一种20 kDa的跨膜细胞表面蛋白，属于免疫球蛋白超家族。 | |||
| M40828
|
Anti-Mouse CTLA-4 (Clone 9H10) In vivo | Anti-Mouse CTLA-4 (Clone 9H10) In vivo | Immunology/Inflammation |
| Cytotoxic T Lymphocyte-Associated Antigen-4 | |||
| Anti-Mouse CTLA-4 (Clone 9H10) recognizes an epitope on mouse CTLA-4. CTLA-4 is expressed on activated T and B lymphocytes. | |||
| M40812
|
Anti-Mouse Ly-6G/Ly-6C (Clone RB6-8C5) In vivo | Anti-Mouse Ly-6G/Ly-6C (Clone RB6-8C5) In vivo | Immunology/Inflammation |
| Anti-Mouse GR-1 | |||
| Anti-Mouse Ly-6G/Ly-6C (Clone RB6-8C5) In vivo has been used to identify peripheral blood neutrophils and deplete granulocytes in vivo. | |||
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