Anti-Mouse CD40 Antibody (Clone FGK45) In vivo
CD40 is a 48 kD type I transmembrane glycoprotein that is a member of the TNFR superfamily. CD40 interacts with TNFR2 and is involved in the regulation of signal transduction. CD40 is a potential target for cancer immunotherapy. CD40 is widely expressed on antigen-presenting cells such as dendritic cells, B cells, macrophages, and monocytes, in addition to non-immune endothelial cells, basal epithelial cells, and a variety of tumors. Clone FGK45 recognizes an epitope on mouse CD40.
化学性质/溶解性/储存
| 储存条件 | Stored sterile as received at 2-8°C for up to one month. For longer term storage, store at -80°C without diluting. Avoid Repeated Freeze Thaw Cycles. |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
生物活性
CD40 is a 48 kD type I transmembrane glycoprotein that is a member of the TNFR superfamily. CD40 interacts with TNFR2 and is involved in the regulation of signal transduction. CD40 is a potential target for cancer immunotherapy. CD40 is widely expressed on antigen-presenting cells such as dendritic cells, B cells, macrophages, and monocytes, in addition to non-immune endothelial cells, basal epithelial cells, and a variety of tumors. Clone FGK45 recognizes an epitope on mouse CD40.
Applications and Recommended Usage
FC The suggested concentration for this FGK45 antibody for staining cells in flow cytometry is ≤ 1.0 μg per 106 cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application.
Clone：FGK45
Formulation：PBS pH 7.2 - 7.4
Reactivity Species：Mouse
Host Species：Rat
Product Concentration：≥ 5.0 mg/ml
Endotoxin：< 1.0 EU/mg
Purity：≥95%
实验参考
建议您制定动物给药及实验方案时，尽量参考已发表的相关实验文献（溶剂种类及配比众多，简单地溶解目的化合物，并不能解决动物给药依从性、体内生物利用度、组织分布等相关问题，未必能保证目的化合物在动物体内充分发挥生物学效用）。
体内实验的工作液，建议您现用现配，当天使用；如在配制过程中出现沉淀、析出现象，可以通过超声和（或）加热的方式助溶。
切勿一次性将产品全部溶解。
请在下面的计算器中，输入您的动物实验相关数据并点击计算，即可得到该实验的总需药量和工作液终浓度。
例如您给药剂量是10 mg/kg，平均每只动物的体重为20 g，每只动物的给药体积是100 μL，动物数量为20只，则该动物实验的总需药量为4 mg，工作液终浓度为2 mg/mL。
1：鉴于实验过程的损耗，建议您至少多配1-2只动物的量；
2：为该产品最终给药时的浓度。
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