白介素 1 (IL-1)是一种多肽,分子质量为17 kd,有IL-1α及IL-1β两种亚型。IL-1ɑ由159个氨基酸组成。
白介素 1 (IL-1)是一种多肽,分子质量为17 kd,有IL-1α及IL-1β两种亚型。IL-1ɑ由159个氨基酸组成。IL-1 受体(IL-1R)几乎存在于所有有核细胞表面,每个细胞的 IL-1R 数目不等,少则几十个(如 t 细胞),多则数千个(如成纤维细胞)。IL-1R 主要有两种类型:一种为 IL-1r1,其分子伸入胞浆内的肽链部分较长,起着传递活化信号的作用;另一种为 IL-1R2,胞内部分的肽段较短不能有效地传递信号,而是将胞外部分的肽链释放到细胞外液中,以游离形式与 IL-1 结合,发挥反馈抑制作用。GM-CSF、G-CSF及 IL-1 自身均可提高细胞 IL-1R 的表达水平,而 TGF 及皮质类固醇能降低 IL-1R 的表达。
通过其诱导人自然杀伤性淋巴瘤 NK-92 细胞分泌干扰素γ 的能力测定,该效应的ED50为 ≤100 ng/mL。
内毒素 <0.1EU/ug
性状 | Lyophilized powder |
溶解性(25°C) | Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml. |
储存条件 | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
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