IL-21 is expressed by CD4+ T cells, natural killer (NK) T cells, and Th17 cells. IL-21 plays a pivotal role in the survival and proliferation of B cells, and their differentiation to immunoglobulin (Ig) producing cells.
别名：Interleukin-21
Interleukin-21 (IL-21) is expressed by CD4+ T cells, natural killer (NK) T cells, and Th17 cells. IL-21 plays a pivotal role in the survival and proliferation of B cells, and their differentiation to immunoglobulin (Ig) producing cells. IL-21 up-regulates and down-regulates the production of IgG1 and IgE by B cells, respectively, and diminishes the severity of allergy and asthma. Interleukin-21 (IL-21) belongs to the Type I four helix bundle cytokines, and shares the common cytokine receptor γ chain with IL-2, IL-4, IL-7, IL-9, and IL-15.
Measured by its ability to enhance IFN-gamma secretion in NK-92 human natural killer lymphoma cells, the ED50 is ≤ 3.0 ng/ml.
Accession # Q9HBE4
Apparent Molecular Weight ~15.4 kDa, reducing conditions
Endotoxin < 0.2 EU/μg
Lyophilized after extensive dialysis against PBS.
| 性状 | Lyophilized powder |
| 溶解性（25°C） | Reconstitute the lyophilized powder in ddH2O to 100 μg/ml. |
| 储存条件 | Stable for up to 6 months at ≤ -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
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