Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. Recombinant human interleukin 17a is produced by the Escherichia coli expression system and expresses the target gene encoding Gly24-Ala155.
别名：Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8
白细胞介素-17是一种由激活的记忆T细胞产生的强效促炎细胞因子。在人类和小鼠中至少有6个IL-17家族成员。由于IL-17与IL-1和tnf - α具有相同的特性，它可能引起关节炎症和骨和软骨破坏。这种细胞因子存在于类风湿性关节炎患者的滑膜液中，由类风湿性关节炎滑膜产生。它增加IL-6的产生，诱导胶原蛋白降解，减少滑膜和软骨的胶原合成以及软骨中的蛋白聚糖合成。IL-17还能增加骨破坏并减少其形成。用特定抑制剂阻断白细胞介素-17提供了软骨和骨退化的保护性抑制。
Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells, the ED50 for this effect is 1-7 ng/ml.
Accession Q16552
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 16 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
| 性状 | Lyophilized powder |
| 溶解性（25°C） | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| 储存条件 | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
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蛋白质研究