重组白细胞介素18结合蛋白(IL-18BP)是一种生理性抑制剂,通过与IL-18的受体结合部位结合而发挥作用。重组小鼠白细胞介素18结合蛋白异型d由哺乳动物表达系统生产,编码Thr29-Ala193的目标基因在C端带有人IgG1 Fc标签。
别名:Interleukin-18 Binding Protein Isoform d
重组白细胞介素18结合蛋白(IL-18BP)是一种生理性抑制剂,通过与IL-18的受体结合部位结合而发挥作用。IL-18刺激INF-γ,然后通过NF-κB刺激18BP的产生。IL-18和IL-18BP之间的相互作用在炎症过程中具有重要作用。IL-18 BPs有四种异构体,a、b、c和d,它们通过不同的方式拼接。IL-18 BP的异构体b和d缺乏一个完整的Ig结构域。IL-18和IL-18BP的表达在免疫组织中被确认,如脾脏,但也在非免疫细胞包括角质细胞中。
溶解性(25°C) | Reconstitute the lyophilized powder in distilled water to a concentration of 100μg/ml |
储存条件 | Stored at ≤ -20°C, stable for one year after receipt |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
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