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Recombinant Mouse IL-18BPd (Mammalian, C-Fc) 重组小鼠IL-18BPd蛋白(Mammalian, C-Fc)

目录号 M21666 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


重组白细胞介素18结合蛋白(IL-18BP)是一种生理性抑制剂,通过与IL-18的受体结合部位结合而发挥作用。重组小鼠白细胞介素18结合蛋白异型d由哺乳动物表达系统生产,编码Thr29-Ala193的目标基因在C端带有人IgG1 Fc标签。

Recombinant Mouse IL-18BPd (Mammalian, C-Fc)结构式

别名:Interleukin-18 Binding Protein Isoform d

规格 价格 库存状态
10ug ¥ 1280 中国库存现货
50ug ¥ 2400 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
生物活性

重组白细胞介素18结合蛋白(IL-18BP)是一种生理性抑制剂,通过与IL-18的受体结合部位结合而发挥作用。IL-18刺激INF-γ,然后通过NF-κB刺激18BP的产生。IL-18和IL-18BP之间的相互作用在炎症过程中具有重要作用。IL-18 BPs有四种异构体,a、b、c和d,它们通过不同的方式拼接。IL-18 BP的异构体b和d缺乏一个完整的Ig结构域。IL-18和IL-18BP的表达在免疫组织中被确认,如脾脏,但也在非免疫细胞包括角质细胞中。

化学性质
溶解性(25°C) Reconstitute the lyophilized powder in distilled water to a concentration of 100μg/ml
储存条件 Stored at ≤ -20°C, stable for one year after receipt
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Malte Bachmann, et al. Front Immunol. A Prominent Role of Interleukin-18 in Acetaminophen-Induced Liver Injury Advocates Its Blockage for Therapy of Hepatic Necroinflammation

[2] Siyoung Lee, et al. Hybridoma (Larchmt). Development of isoform-specific monoclonal antibodies against human IL-18 binding protein

[3] S H Kim, et al. Proc Natl Acad Sci U S A. Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18

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