Interleukin-10 (IL-10) 属于IL-10家族,由许多免疫细胞产生,如 T 细胞、巨噬细胞、肥大细胞和树突状细胞。它通常以同源二聚体的形式分泌,与受体结合后可抑制多种细胞因子的合成,包括活化巨噬细胞和 Th2 细胞产生的 IFN-γ、IL-2、IL-3、TNF 和 GM-CSF。
别名:B-TCGF; CSIF; TGIF
白细胞介素-10(IL-10),最初被称为细胞因子合成抑制因子(CSIF),属于IL-10家族。它由许多免疫细胞产生,如T细胞、巨噬细胞、肥大细胞和树突状细胞。它通常以同源二聚体形式分泌,与受体结合后,抑制一些细胞因子的合成,包括IFN-γ、IL-2、IL-3、TNF和由活化的巨噬细胞和Th2细胞产生的GM-CSF。它还显示出抑制抗原呈递细胞(APC)功能的能力。
在使用C6细胞的生物测定中测得的ED50为 < 8.0 μg/ml。
Protein Construction: IL-10 (Ser19-Asn178)
Accession#: P29456
Apparent Molecular Weight: 8~22 kDa, reducing conditions
Endotoxin < 0.2 EU/μg
Lyophilized after extensive dialysis against PBS.
性状 | Lyophilized powder |
溶解性(25°C) | Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml. |
储存条件 | Stored at ≤ -20°C, stable for up to 6 months after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
[5] P Lu, et al. J Interferon Cytokine Res. Cloning and expression of canine interleukin-10
其他相关的Recombinant Proteins产品 |
---|
Recombinant Human Serpin A12 (E.coli, N-GST)
Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. |
Recombinant Human B2M Protein (Mammalian, C-6His)
β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. |
Recombinant Mouse E-Selectin/CD62E Protein (HEK293)
E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involved in cancer cell metastasis. |
Recombinant Human DPP4/CD26 (Mammalian, C-6His)
DPP4/CD26 is a signal-anchor for type II membrane protein that belongs to the peptidase S9B family. DPP4/CD26 acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. It’s binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. |
Recombinant Human USP14 (E.coli, N-6His)
USP14 belongs to the ubiquitin-specific processing (USP) family which is a deubiquitinating enzyme (DUB) with His and Cys domains. USP14 acts also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. |
产品仅供科学研究或药证申报的用途使用,不为任何个人或者非科研性质的其他用途提供服务。
Copyright © 2010-2022 AbMole版权所有 沪ICP备16047849号 沪公网安备 31011502012228号