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Recombinant Rat IL-10 (CHO) 重组大鼠 IL-10蛋白 (CHO)

目录号 M21121 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


Interleukin-10 (IL-10) 属于IL-10家族,由许多免疫细胞产生,如 T 细胞、巨噬细胞、肥大细胞和树突状细胞。它通常以同源二聚体的形式分泌,与受体结合后可抑制多种细胞因子的合成,包括活化巨噬细胞和 Th2 细胞产生的 IFN-γ、IL-2、IL-3、TNF 和 GM-CSF。

Recombinant Rat IL-10 (CHO)结构式

别名:B-TCGF; CSIF; TGIF

规格 价格 库存状态
10ug ¥ 1872 中国库存现货
50ug ¥ 5760 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
生物活性

白细胞介素-10(IL-10),最初被称为细胞因子合成抑制因子(CSIF),属于IL-10家族。它由许多免疫细胞产生,如T细胞、巨噬细胞、肥大细胞和树突状细胞。它通常以同源二聚体形式分泌,与受体结合后,抑制一些细胞因子的合成,包括IFN-γ、IL-2、IL-3、TNF和由活化的巨噬细胞和Th2细胞产生的GM-CSF。它还显示出抑制抗原呈递细胞(APC)功能的能力。

在使用C6细胞的生物测定中测得的ED50为 < 8.0 μg/ml。


Protein Construction: IL-10 (Ser19-Asn178)

Accession#: P29456

Apparent Molecular Weight: 8~22 kDa, reducing conditions

Endotoxin < 0.2 EU/μg

Lyophilized after extensive dialysis against PBS.

化学性质
性状 Lyophilized powder
溶解性(25°C) Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
储存条件 Stored at ≤ -20°C, stable for up to 6 months after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Yunxia Liu, et al. Toxins (Basel). Study of Anti-Inflammatory and Analgesic Activity of Scorpion Toxins DKK-SP1/2 from Scorpion Buthus martensii Karsch ( Bm K)

[2] Daewook Kim, et al. Mol Ther Methods Clin Dev. AAV-Mediated Combination Gene Therapy for Neuropathic Pain: GAD65, GDNF, and IL-10

[3] Cristine Steen-Louws, et al. Pharm Res. Sialic Acid-Engineered IL4-10 Fusion Protein is Bioactive and Rapidly Cleared from the Circulation

[4] Cassandra Davidson, et al. Transpl Immunol. IL-13 prolongs allograft survival: association with inhibition of macrophage cytokine activation

[5] P Lu, et al. J Interferon Cytokine Res. Cloning and expression of canine interleukin-10

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