| 目录号 | 产品名称 | 产品简介 |
|---|---|---|
| M1658 | Axitinib | Axitinib是一种多靶点抑制剂，作用于VEGFR-1， VEGFR-2，VEGFR-3，PDGFR-β和c-KIT时，其IC50分别为0.1 nM， 0.2 nM， 0.1-0.3 nM， 1.6 nM和1.7 nM。 |
| M2194 | SU5402 | SU 5402是VEGFR2和FGFR1的多靶点抑制剂，IC50分别为20和30 nM。 |
| M1838 | Masitinib | Masitinib (AB1010)是一种新型的Kit和PDGFRα/β抑制剂，IC50分别为200 nM和540 nM/800 nM，但对ABL和c-Fms抑制作用较弱。Phase 2/3。 |
| M1956 | Apatinib mesylate | Apatinib是一种口服生物有效性的VEGFR2选择性抑制剂，IC50为1 nM 。 |
| M1841 | Lenvatinib | Lenvatinib (E7080)是一种多靶点抑制剂，作用于VEGFR2(KDR)/VEGFR3(Flt-4)最有效，IC50为4 nM/5.2，对VEGFR1/Flt-1作用效果稍弱，作用于VEGFR2/3比作用于FGFR1， PDGFRα/β选择性高10倍左右。 |
| M20877 | Toceranib phosphate | Toceranib phosphate is a multitargeted indolinone receptor tyrosine kinase (RTK) inhibitor with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. |
| M20835 | Seralutinib (GB002) | Seralutinib (PK10571, GB002) is a novel PDGFR kinase inhibitor with IC50s of 8 nM and 10 nM for PDGFRα and PDGFRβ in enzyme assays, respectively. |
| M20740 | SU5204 | SU5204 is a tyrosine kinase inhibitor with IC50 of 4 μM and 51.5 μM for FLK-1 (VEGFR-2) and HER2, respectively. |
| M20715 | CS-2660 (JNJ-38158471) | CS-2660 (JNJ-38158471) is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50 of 40 nM. CS-2660 (JNJ-38158471) also inhibits closely related tyrosine kinases such as Ret and Kit with IC50 of 180 nM and 500 nM，while it has no significant activity (>1 microM) against VEGFR-1 and VEGFR-3. |
| M20700 | Vorolanib (X-82) | Vorolanib is an oral, multikinase, dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) with antiangiogenic and antineoplastic activities. |
| M20586 | ZD-4190 | ZD-4190 is a submicromolar inhibitor of VEGF RTK activity in vitro with IC50 values of 29 ± 4 nM and 708 ± 63 nM for KDR and Flt-1, respectively. |
| M20360 | WAY-302159 | WAY-302159 is a novel VEGFR-2 inhibitor. |
| M20358 | WAY-340935 | WAY-340935 is a VEGFR2 kinase inhibitor. |
| M20248 | WAY-637081 | WAY-637081 is a VEGFR2 inhibitor |
| M20201 | WAY-607500 | WAY-607500 is a VEGFR inhibitor. |
| M20170 | WAY-357919 | WAY-357919 is a inhibitor of vascular endothelial growth factor receptor-2. |
| M20107 | WAY-325185 | WAY-325185 altering the lifespan of a eukaryotic organism |
| M20062 | WAY-297629 | WAY-297629 is a VEGFR2 inhibitor. |
| M20044 | WAY-271147 | WAY-271147 is a VEGFR inhibitor |
| M20043 | WAY-271146 | WAY-271146 is a VEGFR inhibitor |
| M20021 | GI-555736 | GI-555736 altering the lifespan of a eukaryotic organism |
| M20019 | CL-230482 | CL-230482 is a PDGFR inhibitor. |
| M20016 | AY-20590 | AY-20590 is a inhibitor of Mcl-1 (for the treatment of cancer and other diseases). |
| M14922 | TG 100801 | TG 100801 是TG 100572的前药，通过去酯化产生TG 100572，开可用于黄斑变性的研究。TG 100572 是多靶点激酶抑制剂，抑制受体酪氨酸激酶 (receptor tyrosine kinases) 和Src激酶 (Src kinases); 对VEGFR1，VEGFR2，FGFR1，FGFR2，PDGFRβ，Fgr，Fyn，Hck，Lck，Lyn，Src，Yes 的 IC50 值分别为2，7，2，16，13，5，0.5，6，0.1，0.4，1，0.2。 |
| M14921 | Telatinib mesylate | Telatinib mesylate (Bay 57-9352 mesylate) 是一种有效的的口服活性的 VEGFR2，VEGFR3，PDGFα 和 c-Kit 抑制剂，IC50 分别为 6 nM，4 nM，15 nM 和 1 nM。 |
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