M2206
|
TH-302 (Evofosfamide) |
TH-302是一种选择性低氧激活的前体药物，靶向作用于实体瘤的hypoxic区域，IC50为19 nM，在缺氧条件下比在有氧条件下细胞毒性增强270倍，细胞色素P450代谢稳定。 |
| M6098
|
Baicalein |
Baicalein（5,6,7-Trihydroxyflavone，Noroxylin，黄芩素）是一种存在于黄芩，木蝴蝶，百里香等植物中的天然黄酮类化合物，具有抗炎和抗癌活性。Baicalein可明显抑制PI3K/Akt/NF-κB途径，同时也可通过上调GPX4，抑制黑素细胞的铁死亡（ferroptosis），用于白癜风和肿瘤的相关研究。 |
| M9325
|
EGTA |
EGTA是一种特殊的钙离子螯合剂，在生理 pH 值 (7.4) 下，Kd 为 60.5 nM，对 Ca2+ 比对 Mg2+ 有很高的特异性。EGTA 显著抑制炎性巨噬细胞的底物粘附能力。 |
| M9330
|
Brij-35 |
Brij-35（月桂醇聚氧乙烯醚）是一种无毒的非离子表面活性剂，可降低非特定蛋白质的吸附，应用于红曲霉深层发酵时，能显著提高红曲色素产量。 |
| M6154
|
2-PMPA tetrasodium |
2-PMPA（PMPA tetrasodium salt）是高效选择性的谷氨酸羧肽酶II (GCPII)抑制剂，IC50值为300 pM。 |
| M2250
|
Pamidronate disodium |
Pamidronate Disodium（帕米膦酸二钠）是一种含氮的双磷酸盐类化合物，具有抑制骨吸收的作用，可用于癌症相关的溶骨性病变等研究。 |
| M9916
|
DPPH |
DPPH (2,2-Diphenyl-1-picrylhydrazyl，2,2-联苯基-1-苦基肼基) 是一种稳定的自由基，可用于测量抗氧化剂的自由基清除活性。 |
| M9194
|
Insulin (human) |
Insulin (human) 是一种多肽激素，其调节血液中的糖（葡萄糖）水平并且由胰岛的β细胞产生。 |
| M3409
|
Formestane |
Formestane（4-hydroxyandrostenedione，福美司坦）是第二代选择性芳香酶抑制剂，IC50为80 nM。 |
| M9665
|
N-(2-amino-2-oxoethyl)acrylamide |
N-(2-Amino-2-oxoethyl)acrylamide（N-acryloyl-glycinamide，丙烯酰基甘氨酰胺）是一种单体，其聚合物能制备水凝胶，并用于酶的固定化。 |
| M7923
|
Myoseverin B |
Myoseverin, a new microtubule-binding molecule, acts reversibly on myoblast proliferation without the cytotoxic effects displayed by nonpurine-based microtubule-disrupting molecules, like taxol, vinblastine, nocodazole. |
| M7920
|
MMPIP |
MMPIP is a potent, selective, allosteric antagonist of metabotropic glutamate receptor 7 (mGluR7). |
| M7919
|
MDL 72527 |
MDL 72527is an inhibitor of polyamine oxidase (spermine oxidase SMO). |
| M7918
|
Mosapride citrate salt dihydrate |
5-HT4受体激动剂和5-HT3 受体拮抗剂。 |
| M7914
|
MOCPAC |
Selective HDAC1 substrate (over HDAC6, class I over class II). |
| M7913
|
Mastoparan 17 |
Inactive analog of mastoparan; useful as negative control. |
| M7912
|
Mastoparan-7 |
G protein activator via Gαi and Gαo stimulation, similar to G protein-coupled receptors; peptide originally isolated from wasp venom. |
| M7909
|
MDL-12,330A hydrochloride |
Adenylyl cyclase inhibitor. |
| M7907
|
MPPG |
Group III/II metabotropic glutamate (mGluR) receptor antagonist. |
| M7904
|
Methiothepin mesylate salt |
Methiothepin mesylate salt is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors. |
| M7900
|
LP44 |
LP44 is a high affinity 5-HT7 receptor agonist. |
| M7899
|
L-655,708 |
Novel ligand selective for the benzodiazepine site of GABAA receptors which contain the α5 subunit. |
| M7898
|
Lidoflazine |
Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia. |
| M7897
|
L-838,417 |
L-838,417 is a novel pharmacology with no efficacy at a 1 subtype, but is partial agonist with equal efficacy at α2, K3 and α5 subtypes. |
| M7896
|
LWH-63 hydrochloride |
Non-peptide CRF1 corticotrophin-releasing factor antagonist. |
| M7894
|
LY311727 |
LY311727 is an orally active; potent secretory Phospholipase A2 (sPLA2; Group IIa) inhibitor. |
| M7893
|
Leptomycin A |
Leptomycins are antifungal antibiotics with unique unsaturated, branched-chain fatty acid structures. |
| M7891
|
Lumefantrine |
Lumefantrine is is an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria. |
| M7890
|
L-365260 |
L-365260是一种高选择性的非肽类胃泌素和脑胆囊收缩素受体的拮抗剂，其 Kis 值分别为 1.9 nM 和 2.0 nM。L-365260还具有抑制神经元去极化、调节应激反应、增强镇痛效果等功能。 |
| M7889
|
LPK-26 |
LPK-26 is an analog of ICI-199441 and (-)U50,488H (classic kappa agonists). |
