M2206
|
TH-302 (Evofosfamide) |
TH-302是一种选择性低氧激活的前体药物，靶向作用于实体瘤的hypoxic区域，IC50为19 nM，在缺氧条件下比在有氧条件下细胞毒性增强270倍，细胞色素P450代谢稳定。 |
| M6098
|
Baicalein |
Baicalein（5,6,7-Trihydroxyflavone，Noroxylin，黄芩素）是一种存在于黄芩，木蝴蝶，百里香等植物中的天然黄酮类化合物，具有抗炎和抗癌活性。Baicalein可明显抑制PI3K/Akt/NF-κB途径，同时也可通过上调GPX4，抑制黑素细胞的铁死亡（ferroptosis），用于白癜风和肿瘤的相关研究。 |
| M9325
|
EGTA |
EGTA是一种特殊的钙离子螯合剂，在生理 pH 值 (7.4) 下，Kd 为 60.5 nM，对 Ca2+ 比对 Mg2+ 有很高的特异性。EGTA 显著抑制炎性巨噬细胞的底物粘附能力。 |
| M9330
|
Brij-35 |
Brij-35（月桂醇聚氧乙烯醚）是一种无毒的非离子表面活性剂，可降低非特定蛋白质的吸附，应用于红曲霉深层发酵时，能显著提高红曲色素产量。 |
| M6154
|
2-PMPA tetrasodium |
2-PMPA（PMPA tetrasodium salt）是高效选择性的谷氨酸羧肽酶II (GCPII)抑制剂，IC50值为300 pM。 |
| M2250
|
Pamidronate disodium |
Pamidronate Disodium（帕米膦酸二钠）是一种含氮的双磷酸盐类化合物，具有抑制骨吸收的作用，可用于癌症相关的溶骨性病变等研究。 |
| M9916
|
DPPH |
DPPH (2,2-Diphenyl-1-picrylhydrazyl，2,2-联苯基-1-苦基肼基) 是一种稳定的自由基，可用于测量抗氧化剂的自由基清除活性。 |
| M9194
|
Insulin (human) |
Insulin (human) 是一种多肽激素，其调节血液中的糖（葡萄糖）水平并且由胰岛的β细胞产生。 |
| M3409
|
Formestane |
Formestane（4-hydroxyandrostenedione，福美司坦）是第二代选择性芳香酶抑制剂，IC50为80 nM。 |
| M9665
|
N-(2-amino-2-oxoethyl)acrylamide |
N-(2-Amino-2-oxoethyl)acrylamide（N-acryloyl-glycinamide，丙烯酰基甘氨酰胺）是一种单体，其聚合物能制备水凝胶，并用于酶的固定化。 |
| M7962
|
NBI 27914 |
NBI 27914 is a CRF1 corticotropin-releasing factor receptor antagonist. |
| M7957
|
(+)-Norfenfluramine hydrochloride |
(+)-Norfenfluramine is the major hepatic metabolite of (+)-fenfluramine and is primarily responsible for the anorexic effect, as well as side effects; (+)-norfenfluramine causes vasoconstriction and a blood pressure increase in rats with normal blood. |
| M7956
|
Necrostatin-7 |
Necrostatin-7 (Nec-7) is a potent inhibitor of necroptosis, a regulated caspase-independent necrotic cell death pathway, distinct from apoptosis. |
| M7955
|
Nucleozin |
Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication. |
| M7954
|
NP603 |
NP603 is a cell-permeable inhibitor of PDGFRβ, FGFR1 and VEGFR2 that binds to ATP pocket. |
| M7953
|
NKY80 |
NKY80 is a selective adenylyl cyclase-V inhibitor with greater than 200-fold selectivity for type V over the type II isoform. |
| M7951
|
Naltrindole isothiocyanate hydrochloride |
Naltrindole isothiocyanate hydrochloride is a selective irreversible δ2 opioid receptor antagonist. |
| M7948
|
NO-711 hydrochloride |
NO-711 is a potent and selective GABA uptake inhibitor that crosses the blood-brain barrier. |
| M7947
|
NSCI |
NSCI is a nonpeptide caspase 3 selective inhibitor. |
| M7946
|
Naloxone methiodide |
Quaternary salt of naloxone that, like the parent compound, is a nonselective antagonist at opioid receptors. |
| M7944
|
NSC43067 |
NSC43067 is a Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket. |
| M7943
|
NAEPA |
Selective lysophosphatidic acid-1 (LPA1) receptor agonist; LPA mimetic. |
| M7941
|
H-8 dihydrochloride |
cAMP和cgmp依赖性蛋白激酶抑制剂。 |
| M7937
|
MADAM dihydrochloride |
High affinity ligand for the serotonin transporter SERT. |
| M7935
|
ML 10302 |
Potent, selective 5-HT4 serotonin receptor agonist. |
| M7933
|
(+)-Muscarine chloride |
Prototype muscarinic acetylcholine receptor agonist; active enantiomer. |
| M7932
|
MRS 2395 |
Antagonist for P2Y12 purinoceptor; inhibits ADP-induced aggregation in rat platelets and antagonizes ADP-induced inhibition of cAMP in rat and human platelets in the presence of PGE1. |
| M7931
|
MBX-102 acid |
MBX-102 is a selective PPAR modulator (SPPARM) and has been shown to inhibit phosphorylation of PPARγ. |
| M7930
|
Metrazoline |
Potent and selective imidazoline binding site ligand. |
| M7928
|
E-4031 |
E-4031 selectively blocks hERG K+ channels. |
