M2206
|
TH-302 (Evofosfamide) |
TH-302是一种选择性低氧激活的前体药物，靶向作用于实体瘤的hypoxic区域，IC50为19 nM，在缺氧条件下比在有氧条件下细胞毒性增强270倍，细胞色素P450代谢稳定。 |
| M6098
|
Baicalein |
Baicalein（5,6,7-Trihydroxyflavone，Noroxylin，黄芩素）是一种存在于黄芩，木蝴蝶，百里香等植物中的天然黄酮类化合物，具有抗炎和抗癌活性。Baicalein可明显抑制PI3K/Akt/NF-κB途径，同时也可通过上调GPX4，抑制黑素细胞的铁死亡（ferroptosis），用于白癜风和肿瘤的相关研究。 |
| M9325
|
EGTA |
EGTA是一种特殊的钙离子螯合剂，在生理 pH 值 (7.4) 下，Kd 为 60.5 nM，对 Ca2+ 比对 Mg2+ 有很高的特异性。EGTA 显著抑制炎性巨噬细胞的底物粘附能力。 |
| M9330
|
Brij-35 |
Brij-35（月桂醇聚氧乙烯醚）是一种无毒的非离子表面活性剂，可降低非特定蛋白质的吸附，应用于红曲霉深层发酵时，能显著提高红曲色素产量。 |
| M6154
|
2-PMPA tetrasodium |
2-PMPA（PMPA tetrasodium salt）是高效选择性的谷氨酸羧肽酶II (GCPII)抑制剂，IC50值为300 pM。 |
| M2250
|
Pamidronate disodium |
Pamidronate Disodium（帕米膦酸二钠）是一种含氮的双磷酸盐类化合物，具有抑制骨吸收的作用，可用于癌症相关的溶骨性病变等研究。 |
| M9916
|
DPPH |
DPPH (2,2-Diphenyl-1-picrylhydrazyl，2,2-联苯基-1-苦基肼基) 是一种稳定的自由基，可用于测量抗氧化剂的自由基清除活性。 |
| M9194
|
Insulin (human) |
Insulin (human) 是一种多肽激素，其调节血液中的糖（葡萄糖）水平并且由胰岛的β细胞产生。 |
| M3409
|
Formestane |
Formestane（4-hydroxyandrostenedione，福美司坦）是第二代选择性芳香酶抑制剂，IC50为80 nM。 |
| M9665
|
N-(2-amino-2-oxoethyl)acrylamide |
N-(2-Amino-2-oxoethyl)acrylamide（N-acryloyl-glycinamide，丙烯酰基甘氨酰胺）是一种单体，其聚合物能制备水凝胶，并用于酶的固定化。 |
| M7776
|
N-Desmethyltamoxifen HCl |
N-Desmethyltamoxifen HCl is the primary metabolite of tamoxifen. |
| M7774
|
DBO-83 |
Novel nicotinic acetylcholine receptor agonist, structurally related to epibatidine, with antinociceptive properties in rodents. |
| M7772
|
Diethylumbelliferyl phosphate |
Diethylumbelliferyl phosphate is a selective, potent cholesterol esterase inhibitor. |
| M7770
|
DPO-1 |
DPO-1 is an inhibitor of human Kv1. |
| M7769
|
Daltroban |
Selective thromboxane A2 receptor antagonist. |
| M7766
|
Domoic acid |
Potent agonist at receptors for excitatory amino acids glutamate and kainate; has highest affinity for AMPA/kainate receptor of any kainate agonist; causes excessive excitation of neurons leading to depletion of energy stores. |
| M7765
|
Diphenylacetohydroxamic acid |
Diphenylacetohydroxamic acid is a class IIa selective histone deacetylase inhibitor. |
| M7762
|
DS2 |
DS2 is a selective positive allosteric modulator of δ-GABAA receptors. |
| M7759
|
DCHC |
DCHC is a SIRT1 activator. |
| M7758
|
1,7-Dimethylxanthine |
Adenosine receptor ligand; major metabolite of caffeine. |
| M7757
|
Dilazep dihydrochloride |
Adenosine uptake inhibitor; coronary and cerebral vasodilator; suppresses effects of ischemia; antiplatelet agent. |
| M7756
|
Dihydroeponemycin |
Dihydroeponemycin is an active derivative of eponemycin an antitumor antibiotic isolated from Streptomyces hygroscopicus. |
| M7753
|
DAPH |
DAPH is an inhibitor of Aβ fibril formation; Protein tyrosine kinase inhibitor, specific for EGFR. |
| M7751
|
DPPE hydrochloride |
DPPE is a potent, selective ligand of the microsomal anti-estrogen binding site. |
| M7750
|
Desvenlafaxine hydrochloride |
Desvenlafaxine hydrochloride is a dual SERT/NET reuptake inhibitor. |
| M7748
|
DAF-FM |
DAF-FM is a highly sensitive, photo-stable fluorescent probe for the detection of nitric oxide (NO). |
| M7745
|
DCB |
Neutral allosteric modulator of the metabotropic glutamate receptor mGluR5. |
| M7740
|
DS1 |
δ-GABAA receptors are emerging as an important pharmacological target. |
| M7739
|
(+)-Butaclamol hydrochloride |
(+)-Butaclamol is a dopamine receptor antagonist; active enantiomer. |
| M7731
|
CHIC-35 |
CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. |
