M9370
|
Recombinant Human TNF α (HEK293, C-His) |
重组人肿瘤坏死因子α（Recombinant Human TNF α）是一个同源三聚体，它在生长调节、分化、炎性反应、病毒复制、肿瘤发生、自身免疫性疾病以及病毒、细菌、真菌和寄生虫感染中都起到重要的作用。 |
| M9413
|
Recombinant Human VEGF165 Protein (HEK293, C-His) |
Recombinant Human VEGF165 重组人VEGF165是一种强有力的生长和血管生成细胞因子，它促进内皮细胞的增殖和存活，促进血管生成和血管通透性。 |
| M10922
|
Recombinant Mouse TGF-beta 1 Protein (Human Cells) |
重组小鼠TGF-beta 1 蛋白 是一种多功能细胞因子，其控制许多生物过程，包括免疫，分化，肿瘤抑制，肿瘤转移，衰老，迁移，伤口愈合，细胞凋亡，细胞分裂，脂肪生成和成骨。ED50为5-25 pg/ml |
| M9391
|
Recombinant Human TGF-β1 (CHO) |
重组人TGF-β1（Recombinant Human TGF-β1）是一种多功能细胞因子，调节细胞增殖、生长、分化和运动，以及细胞外基质的合成和沉积。 |
| M9241
|
Recombinant Human EPO Protein (CHO) |
促红细胞生成素(EPO)是肾脏在细胞缺氧时分泌的一种糖蛋白细胞因子，主要以其在促红细胞生成中的作用而闻名，它负责刺激红系祖细胞的增殖和分化。 |
| M9402
|
Recombinant Human PDGF-BB Protein (HEK293, C-His) |
PDGF 是由两条 12.0-13.5kDa 的多肽链组成的二聚体，分别命名为 PDGF-A 和 PDGF-B 链。PDGFs、PDGF-AA、PDGF-BB 和 PDGF-AB 三种天然存在的 PDGF-AB 是多种细胞类型的有力有丝分裂原，包括平滑肌细胞、结缔组织细胞、骨和软骨细胞以及一些血细胞。 |
| M9987
|
Recombinant Human PDGF-AA Protein (HEK293) |
重组人PDGF-AA蛋白（Recombinant Human PDGF-AA Protein）是一种有效的促细胞分裂剂，适用于多种细胞类型，包括平滑肌细胞，结缔组织细胞，骨骼和软骨细胞以及一些血细胞。 |
| M9981
|
Recombinant Human IL-11 Protein (E. coli) |
重组人IL-11蛋白（Recombinant Human IL-11 Protein）是由成纤维细胞、上皮细胞和破骨细胞等基质细胞产生的一种多功能细胞因子。 |
| M21094
|
Recombinant Rat IL-1β (E. coli) |
白细胞介素-1β（IL-1β）是一种非分泌的促炎症细胞因子，主要由活化的巨噬细胞以及中性粒细胞、上皮细胞和内皮细胞产生。通过使用小鼠 D10S 细胞进行细胞增殖测定，ED50为 < 10.0 pg/ml，相当于比活性 > 1.0 × 108 units/mg。 |
| M10022
|
Recombinant Mouse GM-CSF Protein (CHO) |
重组小鼠GM-CSF蛋白是一种生长因子，可以支持粒细胞巨噬细胞祖细胞的体外集落形成。GM-CSF由许多不同的细胞类型产生，包括活化的 T 细胞、B 细胞、巨噬细胞、肥大细胞、内皮细胞和成纤维细胞等。使用小鼠 FDC-P1 细胞在细胞增殖测定中测得的ED50为<0.05 ng/ml，对应于>2.0 × 107units/mg的比活性。 |
M58332
|
Recombinant Human CDK2 (BEVS) |
CDK2，即细胞周期蛋白依赖性激酶 2，是CDK家族的一员，广泛表达于哺乳动物细胞内，但其功能可被其它CDK家族成员代偿，因此对于大多数正常细胞和组织CDK2是非必须的。然而，在肿瘤发生、细胞分化、减数分裂和听力损伤修复等过程中CDK2却发挥着重要功能，近年来的研究发现CDK2敲降可诱导AML细胞产生分化。CDK通过与相应周期蛋白cyclin和周期蛋白依赖性激酶激活激酶(CAK)产生相互作用，在细胞周期的各个阶段发挥作用，参与细胞的生长、分化、增殖等生理过程，介导细胞周期的有序进行。 |
| M58331
|
Recombinant Human CDK2 (E.Coli) |
CDK2，即细胞周期蛋白依赖性激酶 2，是CDK家族的一员，广泛表达于哺乳动物细胞内，但其功能可被其它CDK家族成员代偿，因此对于大多数正常细胞和组织CDK2是非必须的。然而，在肿瘤发生、细胞分化、减数分裂和听力损伤修复等过程中CDK2却发挥着重要功能，近年来的研究发现CDK2敲降可诱导AML细胞产生分化。CDK通过与相应周期蛋白cyclin和周期蛋白依赖性激酶激活激酶(CAK)产生相互作用，在细胞周期的各个阶段发挥作用，参与细胞的生长、分化、增殖等生理过程，介导细胞周期的有序进行。 |
| M58330
|
Recombinant Human SMARCA2 (BEVS) |
SMARCA2是一种重要的核蛋白，是SWI/SNF复合体的进化保守亚基，该复合体利用ATP水解的能量进行染色质重塑，SMARCA2形成重塑复合体的催化核心，与其他亚基一起，通过ATP依赖的机制改变核小体的结构。SMARCA2的失调在大约10%-20%的实体瘤中发生，包括肺癌、前列腺癌和胃癌。SMARCA2也是PROTAC（蛋白质降解靶向嵌合体）技术的靶点，这是一种新兴的治疗方式，通过招募目标蛋白到E3泛素连接酶来诱导目标蛋白的降解。这种重塑对于调节转录、DNA修复和染色质结构至关重要。 |
| M58198
|
Recombinant Mouse Growth Hormone (E. coli) |
Somatotropin (GH) is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. |
| M58193
|
Recombinant Human Activin A Protein (HEK293) |
重组激活素a（Activin A）是TGF-ß超家族的二聚糖蛋白，其作用包括胚胎分化、妊娠早期滋养层侵袭子宫壁等。激活素A还调节骨骼形成和再生，增强类风湿性关节炎的关节炎症，并触发呼吸系统的致病机制。 |
| M58192
|
Recombinant Human Wnt3a Protein (HEK293, C-hFc) |
Wnt3a是Wnt家族成员之一，参与细胞的自我更新、增殖分化和细胞运动。Wnt3a也是类器官构建中常用的细胞因子。在肠道类器官的培养中，添加Wnt3a 可以帮助支持肠道干细胞的增殖和自我更新。Wnt3a 还可以促进神经前体细胞的增殖和分化，从而支持神经类器官的成熟和功能。 |
| M58183
|
Recombinant Mouse IL-15 (E. coli, N-His) |
Interleukin-15 (IL-15) is a 14-15 kDa glycoprotein with immune regulatory functions in many diverse cell types. As a pleiotropic cytokine, IL-15 mediates the crosstalk between innate immunity and adaptive immunity whose principal role is to kill virally infected cells. IL-15 plays a crucial role in the development, differentiation, and survival of NK cells. |
| M58181
|
Recombinant Mouse C3a (E. coli) |
Complement 3 (C3) is the most abundant component of the complement cascade and the convergent point for all three major complement activation pathways: namely classical, alternative and mannose-binding lectin pathways. |
| M58156
|
Recombinant Human PRDX6 Protein (E. coli, N-6His) |
Peroxiredoxin 6 (PRDX6) belongs to the thiol-specific antioxidant protein family, it is involved in redox regulation of the cell and can reduce Hydrogen peroxide and short chain organic, fatty acid, and phospholipid hydroperoxides. Peroxiredoxin 6 may regulates phospholipid turnover and protectes against oxidative injury. |
| M58154
|
Recombinant Mouse Galectin-1/LGALS1 Protein (E. coli) |
Galectin-1/LGALS1 is a member of the galectins. Galectin-1 contributes to different steps of tumor progression including cell adhesion, migration, and tumor-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. |
| M58149
|
Recombinant Vaccinia virus B18R (HEK293, C-6His) |
B18R is a type I interferon (IFN)-binding protein encoded by the B18R open reading frame in the Western Reserve strain of vaccinia virus. B18R has high affinity for human IFN-alpha and also binds rabbit, bovine, rat, pig, and mouse IFN-alpha and IFN-beta. Secreted B18R binds to uninfected and infected cells. B18R presents at the cell surface and protects cells from the antiviral state. |
| M58144
|
Recombinant Human IL-1R1 (HEK293, C-6His) |
Interleukin 1 receptor, type I (IL-1R1) is an interleukin receptor that belongs to the interleukin-1 receptor family. IL-1R1 is an important mediator involved in many cytokine induced immune and inflammatory responses. It binds to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Recombinant IL1 receptor Type I is a potent antagonist of IL1 action. |
| M58141
|
Recombinant Rat VEGF164 (CHO) |
Vascular endothelial growth factor (VEGF/VEGF-A) is originally known as vascular permeability factor (VPF). VEGF-As are endothelial cell-specific mitogens with angiogenic and vascular permeability-inducing properties. It belongs to the PDGF family with a cysteine-knot structure comprised of eight conserved cysteine residues, and reckoned as a potent mediator in the process of angiogenesis and vasculogenesis in either fetus or adult. |
| M58135
|
Recombinant Human DEFB3 (E. coli) |
Defensins are cationic peptides. It is an important ingredient of the innate immune system. β-defensins are expressed on some leukocytes and epithelial surfaces. Four human β-Defensins have been identified to date: BD-1, BD-2, BD-3 and BD-4. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. |
| M58127
|
Recombinant Human Progranulin Protein (HEK293, C-His) |
Progranulin is also called Proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. |
| M58115
|
Recombinant Human Bcl-2 Protein (E. coli, C-His) |
B-cell leukemia/lymphoma 2, also known as Bcl-2, belongs to the Bcl-2 family. BCL2 blocks the apoptotic death of some cells such as lymphocytes. It also regulates cell death by controlling the mitochondrial membrane permeability and inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor. |
| M58110
|
Recombinant Human RIPK3 Protein (E. coli, N-His) |
RIPK3 是一种控制坏死性凋亡和细胞凋亡的激酶。在坏死性凋亡中，由 TNF-α 和 ZBP1 激活，RIPK3 磷酸化 MLKL，导致膜损伤。 |
| M58101
|
Recombinant Human EGFR Protein (CHO, C-His) |
EGFR, also known as ERBB, ERBB1 and HER1, is a type I transmembrane protein belonging to the tyrosine protein kinase family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. EGFR also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. |
| M57289
|
Recombinant Human ITGB1 (HEK293, C-6His) |
Integrin β-1 (ITGB1) belongs to the integrin β chain family. ITGB1 is an integrin unit associated with very late antigen receptors, which contains one VWFA domain. It is known to conjoin with α-3 subunit to create α3β1 complex that reacts to such molecules as netrin-1 and reelin. |
| M55701
|
Recombinant Human Ferritin Heavy Chain/FTH (E. coli) |
Ferritin heavy polypeptide 1(FTH1), is a ubiquitous intracellular protein. FTH1 has ferroxidase activity and is important for iron homeostasis. Ferritin plays a role in delivery of iron to cells and mediates iron uptake in capsule cells of the developing kidney. Variation of ferritin subunit composition may affect iron absorption and release in different tissues. |
