重组人肿瘤坏死因子α(Recombinant Human TNF α)是一个同源三聚体,它在生长调节、分化、炎性反应、病毒复制、肿瘤发生、自身免疫性疾病以及病毒、细菌、真菌和寄生虫感染中都起到重要的作用。
别名:TNFSF2
重组人肿瘤坏死因子α(Recombinant Human TNF α)是一个同源三聚体,它在生长调节、分化、炎性反应、病毒复制、肿瘤发生、自身免疫性疾病以及病毒、细菌、真菌和寄生虫感染中都起到重要的作用。TNF α除了诱导肿瘤的出血性坏死外,还和肿瘤发生、肿瘤转移、病毒复制、败血性休克、发热、发炎和罗恩氏病、风湿性关节炎、器官移植排斥等自身免疫性疾病发生有关。TNF α是一种在多种肿瘤细胞和其他特定靶细胞中具有细胞毒素效应的强效淋巴因子。
在存在代谢抑制剂放线菌素 D 的情况下,使用 L929 小鼠纤维肉瘤细胞进行细胞毒性测定,该效应的 ED50≤5 ng/mL。
DNA 序列编码人 TNF α(GenBank: ADV31546.2 V77-L233)表达带有 His 标签在 C 末端。
预测的理论分子量为 18.2kD
Toxicol Lett. 2020 Mar 15;321:73-82.
溶解性(25°C) | Dissolve the lyophilized protein in distilled water or PBS. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
储存条件 | Stored at ≤ -20°C, stable for one year after receipt |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
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