M9370
|
Recombinant Human TNF α (HEK293, C-His) |
重组人肿瘤坏死因子α（Recombinant Human TNF α）是一个同源三聚体，它在生长调节、分化、炎性反应、病毒复制、肿瘤发生、自身免疫性疾病以及病毒、细菌、真菌和寄生虫感染中都起到重要的作用。 |
| M9413
|
Recombinant Human VEGF165 Protein (HEK293, C-His) |
Recombinant Human VEGF165 重组人VEGF165是一种强有力的生长和血管生成细胞因子，它促进内皮细胞的增殖和存活，促进血管生成和血管通透性。 |
| M10922
|
Recombinant Mouse TGF-beta 1 Protein (Human Cells) |
重组小鼠TGF-beta 1 蛋白 是一种多功能细胞因子，其控制许多生物过程，包括免疫，分化，肿瘤抑制，肿瘤转移，衰老，迁移，伤口愈合，细胞凋亡，细胞分裂，脂肪生成和成骨。ED50为5-25 pg/ml |
| M9391
|
Recombinant Human TGF-β1 (CHO) |
重组人TGF-β1（Recombinant Human TGF-β1）是一种多功能细胞因子，调节细胞增殖、生长、分化和运动，以及细胞外基质的合成和沉积。 |
| M9241
|
Recombinant Human EPO Protein (CHO) |
促红细胞生成素(EPO)是肾脏在细胞缺氧时分泌的一种糖蛋白细胞因子，主要以其在促红细胞生成中的作用而闻名，它负责刺激红系祖细胞的增殖和分化。 |
| M9402
|
Recombinant Human PDGF-BB Protein (HEK293, C-His) |
PDGF 是由两条 12.0-13.5kDa 的多肽链组成的二聚体，分别命名为 PDGF-A 和 PDGF-B 链。PDGFs、PDGF-AA、PDGF-BB 和 PDGF-AB 三种天然存在的 PDGF-AB 是多种细胞类型的有力有丝分裂原，包括平滑肌细胞、结缔组织细胞、骨和软骨细胞以及一些血细胞。 |
| M9987
|
Recombinant Human PDGF-AA Protein (HEK293) |
重组人PDGF-AA蛋白（Recombinant Human PDGF-AA Protein）是一种有效的促细胞分裂剂，适用于多种细胞类型，包括平滑肌细胞，结缔组织细胞，骨骼和软骨细胞以及一些血细胞。 |
| M9981
|
Recombinant Human IL-11 Protein (E. coli) |
重组人IL-11蛋白（Recombinant Human IL-11 Protein）是由成纤维细胞、上皮细胞和破骨细胞等基质细胞产生的一种多功能细胞因子。 |
| M21094
|
Recombinant Rat IL-1β (E. coli) |
白细胞介素-1β（IL-1β）是一种非分泌的促炎症细胞因子，主要由活化的巨噬细胞以及中性粒细胞、上皮细胞和内皮细胞产生。通过使用小鼠 D10S 细胞进行细胞增殖测定，ED50为 < 10.0 pg/ml，相当于比活性 > 1.0 × 108 units/mg。 |
| M10022
|
Recombinant Mouse GM-CSF Protein (CHO) |
重组小鼠GM-CSF蛋白是一种生长因子，可以支持粒细胞巨噬细胞祖细胞的体外集落形成。GM-CSF由许多不同的细胞类型产生，包括活化的 T 细胞、B 细胞、巨噬细胞、肥大细胞、内皮细胞和成纤维细胞等。使用小鼠 FDC-P1 细胞在细胞增殖测定中测得的ED50为<0.05 ng/ml，对应于>2.0 × 107units/mg的比活性。 |
M58600
|
Recombinant Human ApoE3 Protein (HEK293, C-6His) |
ApoE is a constituent of a subclass of high density of lipoproteins (HDL) involved in cholesterol transport. ApoE mediates high affinity binding of chylomicrons and vLDL particles to the LDL receptor, allowing for specific uptake of these particles by the liver, preventing the accumulation of cholesterol rich particles in the plasma. |
| M58590
|
Recombinant Mouse Granzyme B (HEK293, C-6His) |
Granzyme B (GZMB) is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. |
| M58557
|
Recombinant Human ACAA1 Protein (E. coli, N-His) |
Recombinant Human ACAA1 Protein (E. coli, N-His) expressed the target gene encoding Gly182-Asn424 with an N-His tag. |
| M58556
|
Recombinant Human ACAA2 Protein (E. coli, N-His) |
Recombinant Human ACAA2 Protein (E. coli, N-His) expressed the target gene encoding Arg90-Ala397 with an N-His tag. |
| M58552
|
Recombinant Human Adrenomedullin Protein (HEK293, N-hFc) |
Adrenomedullin is a a hypotensive peptide and has 1 intramolecular disulfide bond. Adrenomedullin and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, adrenomedullin is diuretic and natriuretic, and both adrenomedullin and PAMP inhibit aldosterone secretion by direct adrenal actions. |
| M58551
|
Recombinant Human NQO-1 Protein (E. coli, N-His) |
NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-electron reduction of quinones that results in the production of radical species. |
| M58547
|
Recombinant Human HSP90-alpha / HSP90AA1 Protein (E. coli) |
HSP90AA1 蛋白是一种重要的分子伴侣，可协调对细胞周期控制和信号转导至关重要的特定靶蛋白的成熟和调节。其 ATP 酶活性驱动功能循环，诱导客户蛋白构象变化以进行激活。 |
| M58533
|
Recombinant Human GAPDH Protein (E. coli, C-His) |
GAPDH is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies. Its role as a mediator for cell death has also been highlighted. GAPDH may be genetically associated with late-onset of Alzheimer's disease. |
| M58529
|
Recombinant Human Caspase-3 Protein (E. coli, N-His) |
Caspase-3 蛋白是一种对细胞凋亡至关重要的硫醇蛋白酶，由起始 caspase（CASP8、CASP9 和/或 CASP10）激活。它催化交感神经元中多种蛋白质的裂解，包括 PARP1、SREBP、caspase-6、-7 和 -9、亨廷顿蛋白和 RET。 |
| M58518
|
Recombinant Human ATG5 (E.coli) |
ATG5 is an E2 ubiquitin ligase which is necessary for autophagy. It is activated by ATG7, conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. ATG5 plays an important role in the apoptotic process, possibly within the modified cytoskeleton. |
| M58510
|
Recombinant Mouse GAPDH Protein (E. coli, N-His) |
GAPDH is a pleiotropic enzyme that is overexpressed in apoptosis and in several human chronic pathologies. Its role as a mediator for cell death has also been highlighted. GAPDH may be genetically associated with late-onset of Alzheimer's disease. |
| M58507
|
Recombinant Human Galectin-3 Protein (HEK293, C-His) |
Human Galectin-3, also known as Mac-2, L29, CBP35, and epsilon BP, is classified as a chimeric member of the Galectin superfamily and contains one carbohydrate recognition domain (CRD) linked to a nonlectin domain. LGALS3 (Galectin 3) has an important role in tumor progression through inhibition of apoptosis. |
| M58453
|
Recombinant Human BMP-6 (E.coli, C-His) |
Bone Morphogenetic Protein-6 (BMP-6) is an extracellular multifunctional cytokine that is also a member of the TGF-β family. BMP-6 can bind with the TGF-β receptor and triggers SMAD protein signal transduction. It plays a vital role in regulating hepcidin to maintain iron ions in the body. |
| M58448
|
Recombinant Human ALDH1A1 (E.coli, N-6His) |
Aldehyde Dehydrogenase Family 1 Member A1 (ALDH1A1) is a cytoplasmic enzyme that belongs to the Aldehyde Dehydrogenase family. ALDH1A1 is the second enzyme of the major oxidative pathway of alcohol metabolism. ALDH1A1 binds free retinal and cellular retinol-binding protein-bound retinal. It can convert/oxidize retinaldehyde to retinoic acid. |
| M58396
|
Recombinant Human METRNL Protein (E. coli, N-His) |
METRNL (Meteorin-like protein) is a hormone, released after physical activity (in skeletal muscle) or exposure to cold (in adipose tissue), that induces energy rate. METRNL stimulates energy rate correlate with white fat browning and raise glucose tolerance. The protein stimulates different types of immune cells to enter the fat tissue and start their prothermogenic actions. |
| M58383
|
Recombinant Human HK2 Protein (E. coli, N-His) |
Hexokinase 2 (HK2) is a rate-determining enzyme in aerobic glycolysis, a process upregulated in tumor cells. HK2 expression is controlled by various transcription factors and epigenetic alterations and is heterogeneous in hepatocellular carcinomas (HCCs). |
| M58382
|
Recombinant Human HK2 Protein (Baculovirus-Insect, C-His) |
Hexokinase 2 (HK2) is a rate-determining enzyme in aerobic glycolysis, a process upregulated in tumor cells. HK2 expression is controlled by various transcription factors and epigenetic alterations and is heterogeneous in hepatocellular carcinomas (HCCs). |
| M58375
|
Recombinant Human HER2 Protein (HEK293, C-6His) |
Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and differentiation. |
| M58354
|
Recombinant Human ZRANB3 (BV) |
ZRANB3蛋白是一种DNA 解旋酶和内切酶，ZRANB3蛋白参与DNA修复和重组过程，在DNA双链断裂修复、同源重组等方面发挥关键作用、mRNA前体的可变剪接中发挥重要功能。该蛋白的异常表达或功能失调可能与某些遗传性疾病或癌症的发生发展有关。 |
| M58353
|
Recombinant Human RelB (E.Coli) |
RelB是NF-κB家族中的一个重要成员，它主要参与非经典NF-κB信号通路的激活，并与p100（加工后成为p52）形成异源二聚体，进入细胞核调控靶基因的转录。RelB/p52异源二聚体进入细胞核后，能够结合到靶基因的κB位点上，调控这些基因的转录。这些靶基因通常与免疫细胞的发育、功能以及炎症反应等过程密切相关。 |
