M9370
|
Recombinant Human TNF α (HEK293, C-His) |
重组人肿瘤坏死因子α（Recombinant Human TNF α）是一个同源三聚体，它在生长调节、分化、炎性反应、病毒复制、肿瘤发生、自身免疫性疾病以及病毒、细菌、真菌和寄生虫感染中都起到重要的作用。 |
| M9413
|
Recombinant Human VEGF165 Protein (HEK293, C-His) |
Recombinant Human VEGF165 重组人VEGF165是一种强有力的生长和血管生成细胞因子，它促进内皮细胞的增殖和存活，促进血管生成和血管通透性。 |
| M10922
|
Recombinant Mouse TGF-beta 1 Protein (HEK293) |
重组小鼠TGF-beta 1 蛋白 是一种多功能细胞因子，其控制许多生物过程，包括免疫，分化，肿瘤抑制，肿瘤转移，衰老，迁移，伤口愈合，细胞凋亡，细胞分裂，脂肪生成和成骨。ED50为5-25 pg/ml |
| M9391
|
Recombinant Human TGF-β1 (CHO) |
重组人TGF-β1（Recombinant Human TGF-β1）是一种多功能细胞因子，调节细胞增殖、生长、分化和运动，以及细胞外基质的合成和沉积。 |
| M9241
|
Recombinant Human EPO Protein (CHO) |
促红细胞生成素(EPO)是肾脏在细胞缺氧时分泌的一种糖蛋白细胞因子，主要以其在促红细胞生成中的作用而闻名，它负责刺激红系祖细胞的增殖和分化。 |
| M9402
|
Recombinant Human PDGF-BB Protein (HEK293, C-His) |
PDGF 是由两条 12.0-13.5kDa 的多肽链组成的二聚体，分别命名为 PDGF-A 和 PDGF-B 链。PDGFs、PDGF-AA、PDGF-BB 和 PDGF-AB 三种天然存在的 PDGF-AB 是多种细胞类型的有力有丝分裂原，包括平滑肌细胞、结缔组织细胞、骨和软骨细胞以及一些血细胞。 |
| M9987
|
Recombinant Human PDGF-AA Protein (HEK293) |
重组人PDGF-AA蛋白（Recombinant Human PDGF-AA Protein）是一种有效的促细胞分裂剂，适用于多种细胞类型，包括平滑肌细胞，结缔组织细胞，骨骼和软骨细胞以及一些血细胞。 |
| M9981
|
Recombinant Human IL-11 Protein (E. coli) |
重组人IL-11蛋白（Recombinant Human IL-11 Protein）是由成纤维细胞、上皮细胞和破骨细胞等基质细胞产生的一种多功能细胞因子。 |
| M21094
|
Recombinant Rat IL-1β (E. coli) |
白细胞介素-1β（IL-1β）是一种非分泌的促炎症细胞因子，主要由活化的巨噬细胞以及中性粒细胞、上皮细胞和内皮细胞产生。通过使用小鼠 D10S 细胞进行细胞增殖测定，ED50为 < 10.0 pg/ml，相当于比活性 > 1.0 × 108 units/mg。 |
| M10022
|
Recombinant Mouse GM-CSF Protein (CHO) |
重组小鼠GM-CSF蛋白是一种生长因子，可以支持粒细胞巨噬细胞祖细胞的体外集落形成。GM-CSF由许多不同的细胞类型产生，包括活化的 T 细胞、B 细胞、巨噬细胞、肥大细胞、内皮细胞和成纤维细胞等。使用小鼠 FDC-P1 细胞在细胞增殖测定中测得的ED50为<0.05 ng/ml，对应于>2.0 × 107units/mg的比活性。 |
M66258
|
Recombinant Mouse IL-13 Protein (E. coli, C-His) |
IL-13 是一种属于 IL-4/IL-13 家族的免疫调节细胞因子，其主要作用是减少炎症反应。IL-13 通过由 IL-4Rα 和 IL13Rα1（或 IL13Rα2）组成的受体复合物发出信号。IL-13 与 IL-4 同源，并在单核吞噬细胞、内皮细胞、上皮细胞和 B 细胞上具有许多相同的生物学活性。 |
| M66194
|
Recombinant Mouse Angiopoietin-2/ANGPT2 Protein (HEK293, C-Fc) |
Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Ang-2 may act as either a Tie-2 antagonist or agonist, depending upon its state of multimerization. Ang-2 functions as a pro-angiogenic factor, although it can also induce EC death and vessel regression. Upon its release from quiescent EC, it regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. |
| M66193
|
Recombinant Human Angiopoietin-2/ANGPT2 Protein (HEK293, C-6His) |
Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Ang-2 may act as either a Tie-2 antagonist or agonist, depending upon its state of multimerization. Ang-2 functions as a pro-angiogenic factor, although it can also induce EC death and vessel regression. Upon its release from quiescent EC, it regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. |
| M66191
|
Recombinant Human Angiopoietin-1/ANGPT1 Protein (HEK293, N-Fc) |
Angiopoietin-1 (Ang-1) is a secreted glycoprotein that plays a critical role in the development and maintenance of the vascular system. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. Angiopoietin-1 can protect against pulmonary arterial hypertension, reduce the extent of fibrosis and remodeling in infarcted diabetic myocardium, and enhance tumor progression and metastasis. |
| M66182
|
Recombinant Human GLP1 Protein (HEK293, C-6His) |
GLP1 (Glucagon-like Peptide 1) is a secreted protein and belongs to the glucagon family. GLP-1 protein, secreted by intestinal endocrine cells, promotes insulin secretion, regulates gastrointestinal motility, and inhibits the secretion of GCG protein. In addition, Glucagon is involved in initiating and maintaining hyperglycemic conditions in diabetes. |
| M66181
|
Recombinant Rat IL-3 Protein (Baculovirus-Insect, C-His) |
IL-3 is a potent growth-promoting cytokine that belongs to the group of interleukins. It stimulates basophils, eosinophils, and monocytes, and promotes neural cell proliferation. IL-3 inhibits osteoclast differentiation and activates JAK2-STAT5 pathway. It is involved in a variety of cell activities such as cell growth, differentiation, and apoptosis. IL3/IL-3 has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. |
| M66001
|
Recombinant Human Laminin 521 Protein (HEK293) |
Laminins 是由三条二硫链连接的多肽 α链、β链和γ链 组装而成的大分子量糖蛋白。Laminin 521 蛋白在胚胎发育中参与基底膜组装，支持皮肤、肌肉等组织器官的形成，并在成年组织中维持骨骼肌、心肌等的结构稳态。Laminin 521 蛋白常被用作干细胞培养的基质成分，可维持胚胎干细胞和诱导多能干细胞的自我更新能力。 |
| M65750
|
Recombinant Human AREG Protein (E. coli) |
Amphiregulin (AREG) is a single-pass membrane protein related to Epidermal Growth Factor (EGF) and Transforming Growth Factor Alpha. AREG interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. |
| M65739
|
Recombinant Mouse Osteopontin/SPP1 Protein (HEK293, C-His) |
Osteopontin/SPP1 is a secreted multifunctional glycoprotein. Its putative functions include roles in bone metabolism, immune regulation, wound healing, cell survival, and tumor progression. Osteopontin/SPP1 acts as a cytokine that is involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10. |
| M65718
|
Recombinant Human Prosaposin Protein (HEK293, C-6His) |
Prosaposin (PSAP) is a potent neurotrophic factor. Prosaposin has neuroprotective and glioprotective effects in the nervous system which including facilitating nerve regeneration, protecting myelinating glial cells, ameliorating ischemic damage, rescuing dopaminergic neurons, and serving an important role in cerebellar development. |
| M65715
|
Recombinant Human Laminin 511 Protein (HEK293) |
Laminin 蛋白属于层粘连蛋白 (Laminin) 家族，是细胞外基质 (ECM) 的重要组成部分。Laminin 蛋白连接细胞内外的区室，传递对细胞行为至关重要的信号。 |
| M59309
|
Anti-Mouse IL-11 Rα Polyclonal Antibody |
Anti-Mouse Interleukin-11 Receptor Alpha (IL-11 Rα) recognizes Mouse IL-11 Rα. IL11RA is a functional target in bone metastasis and is considered as a candidate target in human osteosarcoma and provide leads for the development of novel imaging and therapeutic agents for the management of this malignant tumor. |
| M59306
|
Recombinant Mouse CCL1/TCA-3 Protein (HEK293, C-hFc-His, Active) |
重组小鼠 CCL1/TCA-3 是一种细胞趋化因子，通过与细胞表面的 CCR8 趋化因子受体相互作用，吸引单核细胞、自然杀伤细胞、未成熟的 B 细胞核树突状细胞，介导炎症免疫反应、病毒感染以及肿瘤发生等。 |
| M59297
|
Recombinant Rabbit TNF alpha (E. coli) |
Tumor necrosis factor alpha (TNFα) is the prototypic ligand of the TNF superfamily. TNFα is a pleiotropic cytokine that is capable to promote inflammation, to induce apoptotic cell death, and to inhibit tumorigenesis and viral replication. |
| M59294
|
Recombinant Mouse HB-EGF (E. coli) |
Heparin-binding EGF-like growth factor (HB-EGF) is synthesized as a membrane-anchored mitogenic and chemotactic glycoprotein. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function. The transmembrane form of HB-EGF is the unique receptor for diptheria toxin and functions in juxtacrine signaling in cells. |
| M59266
|
Recombinant Rat IFN-γ (CHO) |
Interferon-γ (IFN-γ) is a cytokine produced primarily by T-lymphocytes and natural killer cells. IFN-γ signaling does diverse biological functions primarily related to host defense and immune regulation, including antiviral and antibacterial defense, apoptosis, inflammation, and innate and acquired immunity. |
| M59265
|
Recombinant Mouse IL-25 (E. coli, C-His) |
Interleukin 25 (IL-25) is a cytokine with proinflammatory and anti-inflammatory effects. It can induce NF-κB activation, and stimulate the production of IL-8, which is the major chemotactic substance of neutrophils. |
| M59242
|
Recombinant Mouse CXCL4/PF4 Protein (E. coli, N-His) |
CXCL4/PF4 is a small cytokine belonging to the CXC chemokine family. CXCL4/PF4 is released from the alpha-granules of activated platelets and binds with high affinity to heparin. CXCL4/PF4 has a role in inflammation and wound repair. CXCL4/PF4 neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. CXCL4 is chemotactic for neutrophils and monocytes. It inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. |
| M59177
|
Recombinant Mouse IL-6 (E. coli, C-His) |
Interleukin-6 (IL-6) 是一种多功能细胞因子，可调节各种免疫和炎症反应。IL-6 是由免疫细胞 (如 T 细胞、B 细胞、巨噬细胞) 及非免疫细胞 (如成纤维细胞、内皮细胞、肝细胞) 分泌的多功能细胞因子。IL-6 通过与受体结合传递信号。 |
| M58941
|
Recombinant Human GDF-15 Protein (HEK293 N-hFc) |
Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily. GDF-15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression. |
