重组人TGF-β1(Recombinant Human TGF-β1)是一种多功能细胞因子,调节细胞增殖、生长、分化和运动,以及细胞外基质的合成和沉积。通过抑制 IL-4 依赖性的小鼠 HT-2 细胞的增殖能力来测定的ED50值为 ≤0.5 ng/mL。
别名:TGF-beta1
重组人转化生长因子-β1(Recombinant Human TGF-β1)是几乎所有细胞类型分泌的最丰富的异构体。它最初被认为具有诱导成纤维细胞表型转化的能力。转化生长因子-β、转化生长因子-β1、β2 和β3 三种哺乳动物亚型通过同一受体发出信号,引起相似的生物学反应。它们参与各种生理过程,包括胚胎发生、组织重塑和伤口愈合。它们主要以潜在复合物的形式分泌,储存在细胞表面和细胞外基质中。从潜在复合物中释放生物活性的转化生长因子-β异构体,包括蛋白水解、复合物的加工和/或凝血酶反应素-1 等蛋白质的构象变化。
以抑制小鼠IL-4依赖性的小鼠HT-2细胞的增殖能力来测定,其ED50值为 ≤0.5 ng/mL。
DNA 序列编码人 TGF-β1(NP_000651.3)表达带有 Fc 标签在 C 末端。
重组人 TGF-β1 蛋白包含 374 个氨基酸,预测的理论分子量为 42.2kD。
内毒素:<0.1EU/μg
Allergol Immunopathol (Madr). 2022 Mar 1;50(2):104-114.
6-Gingerol, a functional polyphenol of ginger, reduces pulmonary fibrosis by activating Sirtuin1
数据来源 | Recombinant Human TGF-β1 (AbMole) | |
方法 | SDS-PAGE analyses | |
细胞系/动物模型 | ||
浓度 | ||
处理时间 | ||
实验结果 | The purity is > 97 % by SDS-PAGE analyses. |
溶解性(25°C) | Reconstitute the lyophilized powder in ddH2O or PBS up to 50 μg/ml. |
储存条件 | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
其他相关的Recombinant Proteins产品 |
---|
Recombinant Human B2M Protein (Mammalian, C-6His)
β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. |
Recombinant Mouse E-Selectin/CD62E Protein (HEK293)
E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involved in cancer cell metastasis. |
Recombinant Human DPP4/CD26 (Mammalian, C-6His)
DPP4/CD26 is a signal-anchor for type II membrane protein that belongs to the peptidase S9B family. DPP4/CD26 acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. It’s binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. |
Recombinant Human USP14 (E.coli, N-6His)
USP14 belongs to the ubiquitin-specific processing (USP) family which is a deubiquitinating enzyme (DUB) with His and Cys domains. USP14 acts also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. |
Recombinant Human EpCAM/Trop-1 (Mammalian, C-Fc)
Epithelial Cell Adhesion Molecule (EpCAM) is a signal type I transmembrane glycoprotein. EpCAM plays a role in embryonic stem cells proliferation and differentiation; it up-regulates the expression of FABP5, MYC and Cyclin A and Cyclin E. It is highly and selectively expressed by undifferentiated embryonic stem cells. |
产品仅供科学研究或药证申报的用途使用,不为任何个人或者非科研性质的其他用途提供服务。
Copyright © 2010-2022 AbMole版权所有 沪ICP备16047849号 沪公网安备 31011502012228号