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Recombinant Human TGF-β1 (HEK293, C-Fc) 重组人TGF-β1蛋白 (HEK293, C-Fc)

目录号 M9391 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


重组人TGF-β1(Recombinant Human TGF-β1)是一种多功能细胞因子,调节细胞增殖、生长、分化和运动,以及细胞外基质的合成和沉积。通过抑制 IL-4 依赖性的小鼠 HT-2 细胞的增殖能力来测定的ED50值为 ≤0.5 ng/mL。

Recombinant Human TGF-β1 (HEK293, C-Fc)结构式

别名:TGF-beta1

规格 价格 库存状态
10ug ¥ 2304 中国库存现货
50ug ¥ 6390 中国库存现货
100ug ¥ 9540 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: ≥95%, Endotoxin <0.1EU/ug
  • COA
  • MSDS
生物活性

重组人转化生长因子-β1(Recombinant Human TGF-β1)是几乎所有细胞类型分泌的最丰富的异构体。它最初被认为具有诱导成纤维细胞表型转化的能力。转化生长因子-β、转化生长因子-β1、β2 和β3 三种哺乳动物亚型通过同一受体发出信号,引起相似的生物学反应。它们参与各种生理过程,包括胚胎发生、组织重塑和伤口愈合。它们主要以潜在复合物的形式分泌,储存在细胞表面和细胞外基质中。从潜在复合物中释放生物活性的转化生长因子-β异构体,包括蛋白水解、复合物的加工和/或凝血酶反应素-1 等蛋白质的构象变化。

以抑制小鼠IL-4依赖性的小鼠HT-2细胞的增殖能力来测定,其ED50值为 ≤0.5 ng/mL。

DNA 序列编码人 TGF-β1(NP_000651.3)表达带有 Fc 标签在 C 末端。

重组人 TGF-β1 蛋白包含 374 个氨基酸,预测的理论分子量为 42.2kD。

内毒素:<0.1EU/μg

使用AbMole产品发表的文献
产品使用成果展示
数据来源 Recombinant Human TGF-β1 (AbMole)
方法 SDS-PAGE analyses
细胞系/动物模型
浓度
处理时间
实验结果 The purity is > 97 % by SDS-PAGE analyses.
化学性质
溶解性(25°C) Reconstitute the lyophilized powder in ddH2O or PBS up to 50 μg/ml.
储存条件 Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Jun Li, et al. Kaohsiung J Med Sci. Circ_0001666 upregulation promotes intestinal epithelial cell fibrosis in pediatric Crohn's disease via the SRSF1/BMP7 axis

[2] Kajdaniuk D, et al. Endokrynol Pol. Transforming growth factor β1 (TGFβ1) in physiology and pathology.

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