找到约 54 条 “NHI-2” 相关结果 （用时 0.08 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M2059
|
A-922500 | A-922500 | DGAT |
| DGAT-1 Inhibitor 4a; A922500 | |||
| A922500 (DGAT-1 Inhibitor 4a) 是一种有效，选择性的人类和小鼠DGAT-1抑制剂，IC50分别为9 nM和22 nM，比作用于相关的酰基转移酶，hERG及抗靶面板的选择性高。 | |||
| M2114
|
GSK126 | GSK126 | EZH2 |
| EZH2 inhibitor; GSK2816126A | |||
| GSK126是一种高活性，S-腺苷-蛋氨酸竞争性EZH2甲基转移酶抑制剂，Ki为0.5 nM。 | |||
M2237
|
IWP-2 | IWP-2 | Wnt/beta-catenin |
| Inhibitor of Wnt Production-2 | |||
| IWP-2抑制Wnt信号和分泌，IC50为27 nM，选择性抑制Porcn介导的Wnt棕榈酰化，一般不影响Wnt/β-catenin，且对Wnt刺激的细胞反应没有影响。 | |||
| M2504
|
CFTR(inh)-172 | CFTR(inh)-172 | CFTR |
| CFTR inhibitor 172 | |||
| CFTR(inh)-172 是电势差不依赖性的选择性CFTR抑制剂，Ki为300 nM，对于MDR1，ATP敏感性钾离子通道或者一系列的转运蛋白没有效果。 | |||
| M2785
|
JNK Inhibitor IX (SC202671) | JNK Inhibitor IX (SC202671) | JNK |
| TCS JNK 5a; SC-202671 | |||
| JNK inhibitor IX 是一种高度选择性JNK抑制剂，其作用于JNK2和JNK3的pIC50分别为6.5和6.7。 | |||
| M3639
|
MALT1 inhibitor (MI-2) | MALT1 inhibitor (MI-2) | MALT1 |
| ABM-3912; MI-2 | |||
| MALT1 inhibitor（MI-2）是一种 MALT1 抑制剂 (IC50=5.84 μM)，MALT1 inhibitor（MI-2）直接与 MALT1 结合，不可逆地抑制蛋白酶功能。 | |||
| M5144
|
BMS202 | BMS202 | PD-1/PD-L1 |
| PD-1/PD-L1 inhibitor 2 | |||
| BMS202 (PD-1/PD-L1 inhibitor 2)是一种抑制PD-1/PD-L1相互作用的小分子化合物，IC50为18 nM。 | |||
| M7140 | PIM-1 Inhibitor 2 | PIM-1 Inhibitor 2 | Others |
| PIM-1 Inhibitor 2 is a pim-1 kinase inhibitor. | |||
| M7627
|
BIO | (2'Z,3'E)-6-溴靛玉红-3'-肟 | GSK-3 |
| 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime6BIO; GSK 3 IX; GSK 3 Inhibitor IX; MLS 2052 | |||
| BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052)是一种特异性的GSK-3抑制剂，无细胞试验中作用于GSK-3α/β的IC50为5 nM，比作用于CDK5选择性高16倍以上，也是一种泛JAK抑制剂，对 Tyk2 的IC50值为30 nM。BIO 可在人类黑色素瘤细胞中诱导凋亡。此外，BIO在无外源Sox2下，可以两因子诱导MEFs，并且也是2i诱导的成分之一，可增强多能性相关基因的表达 | |||
| M8543
|
NHI-2 | NHI-2 | LDH |
| NHI-2 是一种乳酸脱氢酶-A（LDHA）以及糖酵解的抑制剂，可用于肿瘤的相关研究。 | |||
| M8775 | DMAT | DMAT | Others |
| Casein kinase II Inhibitor; CK2 Inhibitor | |||
| Casein kinase II inhibitor II (Ck2 Inhibitor II) is a high affinity ATP-competitive inhibitor of casein kinase II. | |||
| M8887
|
Btk inhibitor 2 | Btk inhibitor 2 | BTK |
| BGB-3111 | |||
| Btk inhibitor 2 (BGB-3111) 是一种布鲁顿酪氨酸激酶 (BTK) 抑制剂。 | |||
| M9145
|
MI-2 | MI-2 | Histone Methyltransferase |
| Menin-MLL Inhibitor 2 | |||
| MI-2 (Menin-MLL Inhibitor 2)是一种有效的menin-MLL相互作用抑制剂，IC50为446±28 nM。 | |||
| M9270
|
COH29 | COH29 | DNA/RNA Synthesis |
| RNR Inhibitor COH29 | |||
| COH29 (RNR Inhibitor COH29) 是一种高效，具有抗癌活性的核糖核苷酸还原酶 (RNR) 抑制剂，可以干扰DNA合成（DNA Synthesis）和修复，IC50为16 μM。 | |||
| M9642
|
EGFR inhibitor 324674 | EGFR inhibitor 324674 | EGFR/HER2 |
| EGFR-IN-12 | |||
| EGFR inhibitor 324674 is a cell permeable, potent and selective EGFR inhibitor with IC50 of 21 nM. | |||
| M10741
|
ERK1/2 inhibitor 2 | ERK1/2 inhibitor 2 | ERK |
| ERK1/2 inhibitor 2 (Example 1) 是有效的 ERK1/2 双重抑制剂。ERK1/2 inhibitor 2 具有抗癌活性。 | |||
| M11251
|
Gartisertib | Gartisertib | ATM/ATR |
| VX-803; M4344; ATR inhibitor 2 | |||
| Gartisertib (VX-803) 是一种 ATP 竞争性的，具有口服活性的，选择性的 ATR 抑制剂，Ki<150 pM。Gartisertib 抑制 ATR 驱动的磷酸化检查点激酶-1 (Chk1) 磷酸化, IC50值为 8 nM。具有抗肿瘤活性。 | |||
| M12541 | ChemBridge-6057025 | ChemBridge化合物-6057025 | Screening Compounds and Building Blocks |
| 1-(4-bromo-3-methylphenyl)-5-[3-(2-furyl)-2-propen-1-ylidene]-2,4,6(1H,3H,5H)-pyrimidinetrione (6057025) | |||
| ChemBridge特有类药化合物/先导化合物-6057025，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M12810 | ChemBridge-6907816 | ChemBridge化合物-6907816 | Screening Compounds and Building Blocks |
| 5-[(2-methoxy-5-nitrobenzyl)thio]-1,3,4-thiadiazol-2-amine (6907816) | |||
| ChemBridge特有类药化合物/先导化合物-6907816，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M13682 | HSP27 inhibitor J2 | HSP27 inhibitor J2 | HSP |
| HSP27 inhibitor J2 (J2) 是一种 HSP27 抑制剂，其显著诱导异常 HSP27 二聚体形成并抑制 HSP27 巨聚合物的产生，从而具有抑制 HSP27 的伴侣功能和降低其细胞保护功能的作用。HSP27 inhibitor J2 (J2) 显著增强 17-AAG 的抗增殖活性，并对顺铂诱导的肺癌细胞生长抑制具有敏感性。 | |||
| M13731 | ROCK inhibitor-2 | ROCK inhibitor-2 | ROCK |
| ROCK inhibitor-2 是一种选择性 ROCK1 和 ROCK2 双抑制剂，IC50 值分别为 17 nM 和2 nM。 | |||
| M14163 | Cot inhibitor-2 | Cot inhibitor-2 | MAPKAPK2/MAP3K/MAP4K |
| Cot inhibitor-2 是一种有效的，选择性的，具有口服活性的 cot (Tpl2/MAP3K8) 抑制剂，IC50 为 1.6 nM。Cot inhibitor-2 抑制 LPS 刺激的人全血中 TNF-α 的产生，IC50 为 0.3 μM。 | |||
| M14291 | DGAT-1 inhibitor 2 | DGAT-1 inhibitor 2 | DGAT |
| DGAT-1 inhibitor 2是一种有效的DGAT-1抑制剂，可用于肥胖的相关研究。 | |||
| M15012
|
Recombinant Human TIMP-2 (HEK293,C-6His) | 重组人TIMP-2蛋白（HEK293,C-6His） | Cytokines and Growth Factors |
| Metalloproteinase Inhibitor 2; CSC-21K | |||
| TIMP-2 is a non N-glycosylated protein with a molecular mass of 22 kDa. It produced by a wide range of cell types, which inhibits MMPs non-covalently by the formation of binary complexes and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-2 also has erythroid‑potentiating and cell growth promoting activities. | |||
| M14854
|
PI3K/mTOR Inhibitor-2 | PI3K/mTOR Inhibitor-2 | PI3K |
| PI3K/mTOR Inhibitor-2 是一种有效的双重 pan-PI3K/mTOR 抑制剂，抑制 PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ 的 IC50 值为 3.4/34/16/1 nM，mTOR 的 IC50 值为 4.7 nM。抗肿瘤活性。 | |||
| M14905
|
PKA Inhibitor Fragment (6-22) amide TFA | PKA Inhibitor Fragment (6-22) amide TFA | PKA |
| PKI-(6-22)-amide TFA | |||
| PKA Inhibitor Fragment (6-22) amide TFA 是 cAMP 依赖性蛋白激酶 A (PKA) 的抑制剂，Ki 值为 2.8 nM。PKA Inhibitor Fragment (6-22) amide TFA 可显着逆转小鼠低水平的吗啡缓解疼痛的感受性。 | |||
| M14935
|
YB-0158 | YB-0158 | Wnt/beta-catenin |
| Wnt pathway inhibitor 2 | |||
| YB-0158 (Wnt pathway inhibitor 2) 是一种反向转肽模拟物和一种有效的结直肠癌干细胞 (CSC) 靶向剂。YB-0158 破坏 Sam68-Src 相互作用并诱导结直肠癌细胞凋亡。YB-0158 具有抗癌活性。 | |||
| M20595 | K-Ras(G12C) inhibitor 12 | K-Ras(G12C) inhibitor 12 | ROCK |
| K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C). | |||
| M20631 | BTK inhibitor 1 (Compound 27) | BTK inhibitor 1 (Compound 27) | BTK |
| BTK inhibitor 1 (compound 27) is an inhibitor of BTK with an IC50 of 0.11 nM for Btk and inhibits B cell activation in hWB with an IC50 of 2 nM. | |||
| M20738 | Eph-inhibitor-1 | Eph-inhibitor-1 | Ephrin Receptor |
| Eph inhibitor 2 | |||
| Eph-inhibitor-1 (Eph inhibitor 2) 是一种 Eph 家族酪氨酸激酶抑制剂。 | |||
| M1801
|
KU-55933 | KU-55933 | ATM/ATR |
| KU55933 | |||
| KU-55933 (ATM Kinase Inhibitor)是一种有效的，特异性ATM抑制剂，IC50/Ki为12.9 nM/2.2 nM，与DNA-PK， PI3K/PI4K， ATR和mTOR相比，作用于ATM具有高度选择性。 | |||
| M1859
|
RepSox (ALK5 Inhibitor II) | RepSox (ALK5 Inhibitor II) | ALK |
| RepSox; E-616452; SJN 2511; 616452 | |||
| RepSox (ALK5 Inhibitor II)是一种有效的，选择性TGFβ/ALK5抑制剂，ATP与ALK5结合以及ALK5自磷酸化时， IC50分别为23 nM和4 nM。此外，RepSox可替代 Sox2，单独去除会引起 hCiPS 的诱导失败。 | |||
| M2085
|
Tie2 kinase inhibitor | Tie2 kinase inhibitor | Others |
| Tie2 kinase inhibitor 1; compound 5 | |||
| Tie2 kinase inhibitor是一种有效的，选择性 Tie2 激酶抑制剂，选择性作用于Tie2，IC50为0.25 μM，比作用于p38效果高200倍。 | |||
| M2497
|
Cathepsin Inhibitor 1 | Cathepsin Inhibitor 1 | Cathepsin |
| Cathepsin Inhibitor 1是一种组织蛋白酶(L，L2，S，K，B)的抑制剂，pIC50分别为7.9，6.7，6.0，5.5，5.2。 | |||
| M2768
|
IKK-16 | IKK-16 | IκB/IKK |
| IKK-16 (IKK Inhibitor VII)是一种选择性的IκB kinase(IKK)抑制剂，作用于IKK-2， IKK complex和IKK-1，IC50分别为40 nM， 70 nM和200 nM。 | |||
| M2861
|
MM-102 | MM-102 | Histone Methyltransferase |
| HMTase Inhibitor IX | |||
| MM-102 (HMTase Inhibitor IX) 是一种具有细胞渗透性，紧密结合的 MLL1-WDR5 相互作用肽类抑制剂 (IC50=2.4 nM)。 | |||
| M3634
|
TAPI-1 | TAPI-1 | Immunology/Inflammation |
| TAPI-1（TNF-α processing inhibitor-1）是一种ADAM17/TACE(TNF-α转化酶)抑制剂，可通过抑制TACE 介导的可溶性TNF-α及其受体的释放，从而减少其他炎症因子的产生。此外，TAPI-1能在稳定表达M3毒蕈碱受体的HEK-293细胞中，减少组成型和毒蕈碱受体刺激的sAPP释放，IC50分别为8.09 μM和3.61 μM，可用于关节炎的相关研究， | |||
| M3931
|
Aurora Kinase Inhibitor III | Aurora Kinase Inhibitor III | Aurora Kinase |
| Aurora Kinase Inhibitor 3 | |||
| Aurora Kinase Inhibitor III是一种有效的，选择性 Aurora A 激酶抑制剂，IC50 为 42 nM。 | |||
| M1261
|
NFAT Inhibitor-1 (VIVIT peptide) | NFAT Inhibitor-1 (VIVIT peptide) | NFAT |
| VIVIT peptide; NFAT Inhibitor; ABM-7733 | |||
| NFAT Inhibitor-1 (VIVIT peptide) 是一种 NFAT 的细胞渗透性肽抑制剂，在抑制细胞提取物中钙调神经磷酸酶介导的NFAT1、NFAT2和NFAT4去磷酸化方面表现优异。 | |||
| M25389
|
Rheb inhibitor NR1 | Rheb inhibitor NR1 | mTOR |
| Rheb inhibitor NR1 是一种 Rheb 抑制剂，IC50 为 2.1 μM。Rheb inhibitor NR1 可直接结合 Rheb switch II 结构域，选择性抑制 mTORC1 的激活。Rheb inhibitor NR1 不影响 mTORC2 的活性。 | |||
| M4909
|
GSK2801 | GSK2801 | Epigenetic Reader Domain |
| GSK2801 is a selective bromodomains BAZ2A/B inhibitor with KD of 257 nM and 136 nM, respectively. | |||
| M4948
|
SAR191801 | SAR191801 | PGE synthase |
| hPGDS-IN-1 | |||
| hPGDS-IN-1 is a hPGDS inhibitor ,with IC50 of 12 nM in the Fluorescence Polarization Assay or the EIA assay. | |||
| M4988
|
AKT inhibitor VIII | AKT inhibitor VIII | Akt |
| Akt Inhibitor VIII是一种细胞渗透性喹恶aline化合物，已被证明可以有效、选择性、变结构和可逆地抑制Akt1、Akt2和Akt3的活性(IC50 = 58 nM、210 nM和2.12 μM;分别)。 | |||
| M5027
|
CPI-169 racemate | CPI-169 racemate | EZH2 |
| CPI-169 racemate is the racemate form of CPI-169, which is a novel and potent EZH2 inhibitor with IC50 <1 nM(inhibition of the catalytic activity of PRC2). | |||
| M5128
|
PFI-2 | PFI-2 | Histone Methyltransferase |
| (R)-PFI-2 | |||
| PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets. | |||
| M5136
|
GSK-LSD1 dihydrochloride | GSK-LSD1 dihydrochloride | Histone demethylase |
| GSK-LSD1 2HCl | |||
| GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B). | |||
| M40771
|
Recombinant Human CTLA-4 Protein (HEK293, C-6His) | 重组人CTLA-4蛋白 (HEK293, C-6His) | Cytokines and Growth Factors |
| Cytotoxic T-lymphocyte-associated antigen 4 | |||
| Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. | |||
| M58584
|
(E)-Akt inhibitor-IV | (E)-Akt inhibitor-IV | Akt |
| CS-1992 | |||
| (E)-Akt inhibitor-IV 是一种 PI3K-Akt 抑制剂，具有显著的细胞毒性。(E)-Akt inhibitor-IV 对四种细胞系 (MDA-MB468 细胞、MDA-MB231 细胞、MCF7 细胞和 184B5 细胞) 的平均 GI20 为 0.04 μM。 | |||
| M6463 | ARP 101 | ARP 101 | Others |
| ARP 101 is a inhibitor of MMP-2. | |||
| M6651 | Damnacanthal | 丹宁卡；丹拿堪索 | Others |
| Damnacanthal is a potent, selective p56 lck inhibitor; also LIMK1/2 inhibitor. | |||
| M6712 | EO 1428 | EO 1428 | Others |
| EO 1428 is a selective inhibitor of p38α and p38β 2. | |||
| M7207 | Ro 26-4550 trifluoroacetate | Ro 26-4550 trifluoroacetate | Others |
| Ro 26-4550 trifluoroacetate is a competitive inhibitor of IL-2/ IL-2Rα receptor interaction. | |||
| M7306
|
SL 327 | SL 327 | MEK |
| SL 327 is a selective inhibitor of MEK1 and MEK2; brain penetrant. | |||
| M7709
|
CR8 | CR8 | PROTAC |
| CR8 is a potent and selective inhibitor of cyclin dependent kinase (CDK1, 2, 5, 7, and 9). | |||
