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Recombinant Human TIMP-2 (Mammalian,C-6His) 重组人TIMP-2蛋白(Mammalian,C-6His)

目录号 M15012 所有产品仅供科研使用,严禁用于人或动物的治疗等任何其他用途,不为任何个人提供产品和服务  


重组人TIMP-2蛋白(Mammalian,C-6His)是由哺乳动物表达系统产生的,目的基因编码Cys27-Pro220在c端表达6His标记。Accession #: P16035。

Recombinant Human TIMP-2 (Mammalian,C-6His)结构式

别名:Metalloproteinase Inhibitor 2; CSC-21K

规格 价格 库存状态
10ug ¥ 2800 中国库存现货
50ug ¥ 8400 中国库存现货
其他规格数量报价?

质量标准及产品资料
  • 纯度: >95% , Endotoxin <1 EU/ug
  • COA
  • MSDS
生物活性

表达系统:Mammalian

纯度:还原SDS-PAGE测定大于95%

内毒素:经LAL测试,小于0.1 ng/ug (1 EU/ug)

存储及稳定性:冻干蛋白应在< -20°C保存,但在室温下可保存3周。重组蛋白溶液可在4-7℃下保存2-7天。重组样品的等分液在< -20°C下稳定3个月


生物活性:金属蛋白酶组织抑制剂或TIMPs是调节锌酶的活化和蛋白水解活性的蛋白家族,被称为基质金属蛋白酶(MMPs)。组织金属蛋白酶抑制剂2 (TIMP-2)是一种非n -糖基化蛋白,分子量为22 kDa。它由多种细胞类型产生,通过形成二元复合物以非共价方式抑制基质金属蛋白酶,并通过结合其催化锌辅因子不可逆地失活基质金属蛋白酶。TIMP-2还具有促红细胞生长性和促细胞生长活性。

化学性质
溶解性(25°C) It is not recommended to reconstitute to a concentration less than 100 μg/ml.
储存条件 粉末型式       -20°C   3年;4°C   2年
溶于溶剂       -80°C   6个月;-20°C   1个月
运输方式 冰袋运输,根据产品的不同,可能会有相应调整。
参考文献

[1] Aiying Xue, et al. Sheng Wu Gong Cheng Xue Bao. [Prokaryotic expression, purification and characterization of tissue inhibitor of metalloproteinase-2]

[2] Lena Vinther, et al. Protein Expr Purif. Purification and characterization of bioactive his6-tagged recombinant human tissue inhibitor of metalloproteinases-1 (TIMP-1) protein expressed at high yields in mammalian cells

[3] L Xu, et al. Gut. Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis

[4] Heidi S-T Kai, et al. J Biol Chem. Utilization of a novel recombinant myoglobin fusion protein expression system to characterize the tissue inhibitor of metalloproteinase (TIMP)-4 and TIMP-2 C-terminal domain and tails by mutagenesis. The importance of acidic residues in binding the MMP-2 䲧璵Ỵ璶㧀璴羹癦

[5] R Fridman, et al. Biochem J. Expression of human recombinant 72 kDa gelatinase and tissue inhibitor of metalloproteinase-2 (TIMP-2): characterization of complex and free enzyme

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关键词:Recombinant Human TIMP-2 (Mammalian,C-6His), Metalloproteinase Inhibitor 2; CSC-21K, Recombinant Human TIMP-2 (Mammalian,C-6His)供应商, Recombinant Proteins抑制剂, 购买Recombinant Human TIMP-2 (Mammalian,C-6His), Recombinant Human TIMP-2 (Mammalian,C-6His)溶解度, Recombinant Human TIMP-2 (Mammalian,C-6His)结构式








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