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STAT Signal transduction and activator of transcription

抑制剂

目录号 产品名称 产品简介
M10077 Colivelin Colivelin 是一种脑渗透性的神经保护肽,对神经退行性疾病中的 Aβ 沉积,神经元凋亡和突触可塑性缺陷具有有效的长期作用,Colivelin 也是一种 STAT3 的激活剂。
M9769 BP-1-102 BP-1-102是一种有效的,口服可生物利用的,选择性的STAT3抑制剂,其IC50值为6.8 μM。
M9706 Colivelin TFA Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3.
M9077 STAT5-IN-1 STAT5-IN-1是一种可透过细胞的非营养性烟酰腙抑制剂,它通过与SH2结构域的结合来抑制Stat5,对STAT5β亚型的IC50值为47 μM。
M8874 C188-9 C188-9 is a small-molecule STAT3 inhibitor, can block Th2 and Th17 cell expansion and cytokine production to prevent house dust mite (HDM)-induced airway inflammation and remodeling.
M7539 AS1517499 AS1517499是一种新型有效的STAT6抑制剂,IC50为21 nM。
M5264 SH5-07 SH5-07是一种强效的异羟肟酸类STAT3抑制剂,在体内外具有抗肿瘤活性。
M5018 Corylifol A Corylifol A is a phenolic compounds isolated from Psoralea corylifolia; inhibits IL-6-induced STAT3 activation and phosphorylation(IC50=0.8 uM).
M4622 Garcinone D Garcinone D是一种来自山竹的天然呫吨酮,以浓度和时间依赖的方式增加磷酸化信号转导子和转录激活因子3(p-STAT3)蛋白水平。
M3982 Cryptotanshinone Cryptotanshinone is a potent anticancer agent targeting the activation STAT3 protein with antitumor activity.
M3970 Scutellarin Scutellarin, a flavonoid glycoside, is the primary active ingredient in breviscapine that is a mixture of flavonoid glycosides extracted from a Chinese herb Erigeron breviscapus (Vant.) Hand.-Mazz.
M3928 Scoparone Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver.
M3664 SH-4-54 SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.
M3648 HO-3867 HO-3867, an analog of curcumin, is a selective STAT3 inhibitor.
M3032 Stattic Stattic是第一个非肽类小分子,有效抑制STAT3激活和核易位,IC50为5.1 μM,高选择性作用于STAT1。
M2883 Nifuroxazide Nifuroxazide是一种可渗透细胞的,口服有效的硝基呋喃类化合物抑制剂,有效地抑制细胞内STAT1/3/5转录活性的激活,IC50为3 µM。
M2055 Niclosamide Niclosamide抑制DNA复制,抑制STAT,IC50为0.7 μM。
M2028 Fludarabine Fludarabine是一种STAT1活性抑制剂和DNA合成抑制剂。
M1782 NSC 74859 S3I-201有效抑制fSTAT3DNA结合活性,IC50为86 μM,对STAT1和STAT5抑制作用弱。
M1293 Artesunate Artesunate 是一种潜在的STAT3抑制剂,作用于小细胞肺癌细胞系H69,IC50值为< 5 μM,也用于抗疟类研究。
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热门STAT产品
HO-3867

HO-3867, an analog of curcumin, is a selective STAT3 inhibitor.

Scutellarin

Scutellarin, a flavonoid glycoside, is the primary active ingredient in breviscapine that is a mixture of flavonoid glycosides extracted from a Chinese herb Erigeron breviscapus (Vant.) Hand.-Mazz.

Cryptotanshinone

Cryptotanshinone is a potent anticancer agent targeting the activation STAT3 protein with antitumor activity.



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