Cryptotanshinone 隐丹参酮

目录号 M3982 所有产品仅供科研使用，严禁用于人或动物的治疗等任何其他用途，不为任何个人提供产品和服务

Cryptotanshinone是一种从丹参的根中提取的天然化合物，抑制 STAT3 的 IC50 为4.6 μM，具有潜在的抗肿瘤活性。

别名：CTS

规格	价格	库存状态
Free Sample (0.5-1 mg)	¥ 0	中国库存现货
10mM*1mL in DMSO	¥ 280	中国库存现货
10mg	¥ 350	中国库存现货
25mg	¥ 630	中国库存现货
50mg	¥ 945	中国库存现货

其他规格数量报价？

质量标准及产品资料

纯度： >98%
COA
MSDS

产品信息

生物活性

Cryptotanshinone was originally isolated from the dried roots of Salvia militorrhiza, an herb that is used extensively in Asian medicine and that is known to exert beneficial effects on the circulatory system.Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells and the growth of the cells through 96 hours of the treatment.Cryptotanshinone significantly attenuated atherosclerotic plaque formation and enhanced plaque stability in ApoE-/- mice by inhibiting lectin-like oxLDL receptor-1 (LOX-1) and matrix metalloproteinase-9 (MMP-9) expression, as well as inhibiting reactive oxygen species (ROS) generation and nuclear factor- kappa B (NF-κB) activation.In vitro,Cryptotanshinone decreased oxLDL-induced LOX-1 mRNA and protein expression, and thereby, inhibited LOX-1-mediated monocytes adhesion to HUVECs through reducing the expression of adhesion molecules (ICAM-1 and VCAM-1).Cryptotanshinone inhibited NADPH oxidase subunit 4 (NOX4)-mediated ROS generation and consequent activation of NF-κB in HUVECs.

使用AbMole产品发表的文献

Inflammation. 2023 Oct 7.

Suppression of IRF9 Promotes Osteoclast Differentiation by Decreased Ferroptosis via STAT3 Activation
Front Immunol. 2022 Feb 7;13:820685.

The Study on the Regulation of Th Cells by Mesenchymal Stem Cells Through the JAK-STAT Signaling Pathway to Protect Naturally Aged Sepsis Model Rats
Research Square. 2020 Feb 13.

STAT3 signaling pathway could be involved in the progress of cognitive dysfunction caused by ligature-induced periodontitis
Acta Pharmacol Sin. 2019 Dec 17.

Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats.

产品使用成果展示

	数据来源	Customer experimental result (2018).
	方法	Western blot & Cell viability assay
	细胞系/动物模型
	浓度	20 μmol/L
	处理时间	48 h
	实验结果	After treatment with STAT3 inhibitor cryptotanshinone (20 μmol/L) for 48 h, the expression of p-STAT3 and STAT3 was detected by Western blot. Effect on cell viability at 48 h of the STAT3 inhibitor cryptotanshinone is shown on the right.

实验参考

体外实验*
细胞系	KATO III, DU145, PC3, LNCaP, MDA-MB-231, MDA-MB-468, MDA-MB-453, MCF-7, MCF-10A, HeLa and HCT-116
方法	Exposing cells to Cryptotanshinone for 24 or 48 hours. For the determination of cell proliferation, adding the cell proliferation reagent WST-1 and using an ELISA reader to measure WST-1 formazan quantitatively at 450 nm.
浓度	Dissolved in DMSO, final concentrations ~50 μM
处理时间	24 or 48 hours

*上述方法来自公开文献，仅供相同目的实验参考。如实验目的、材料、方法不同，请参考其他文献。

体内实验*
动物模型	Zucker Diabetic Fatty (ZDF) (male) type 2 diabetic rat, ob/ob mice (C57BL/6J-Lepob), db/db mice (C57BL/KsJ-Leprdb) and male C57BL/6J mice with high-fat diet-induced obesity
配制	Dissolved in 0.1% solution of sodium lauryl sulfate
剂量	~600 mg/kg/day
给药处理	Orally

*上述方法来自公开文献，仅供相同目的实验参考。如实验目的、材料、方法不同，请参考其他文献。

化学性质

分子量	296.36
分子式	C19H20O3
CAS号	35825-57-1
溶解性（25°C）	DMSO 3 mg/mL
储存条件	粉末型式 -20°C 3年；4°C 2年溶于溶剂 -80°C 6个月；-20°C 1个月
运输方式	冰袋运输，根据产品的不同，可能会有相应调整。

储备液配制

*下述溶液配置方法仅为基于分子量计算出的理论值。不同产品在配置溶液前，需考虑其在不同溶剂中的溶解度限制。

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.3743 mL	16.8714 mL	33.7427 mL
5 mM	0.6749 mL	3.3743 mL	6.7485 mL
10 mM	0.3374 mL	1.6871 mL	3.3743 mL

不同实验动物依据体表面积的等效剂量转换表（参考来源于公开文献）

	小鼠	大鼠	兔	豚鼠	仓鼠	狗
重量 (kg)	0.02	0.15	1.8	0.4	0.08	10
体表面积 (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m 系数	3	6	12	8	5	20

动物 A (mg/kg) = 动物 B (mg/kg) ×	动物 B的K_m系数
	动物 A的K_m系数

例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的K_m系数（3），再除以大鼠的K_m系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。

参考文献

[1] Liu Z, et al. Br J Pharmacol. Cryptotanshinone, an orally bioactive herbal compound from Danshen, attenuates atherosclerosis in Apolipoprotein E-Deficient Mice: role of LOX-1.

[2] Shin DS, et al. Cancer Res. Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells.

[3] Kim EJ, et al. Mol Pharmacol. Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase.

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