M2206
|
TH-302 (Evofosfamide) |
TH-302是一种选择性低氧激活的前体药物，靶向作用于实体瘤的hypoxic区域，IC50为19 nM，在缺氧条件下比在有氧条件下细胞毒性增强270倍，细胞色素P450代谢稳定。 |
| M6098
|
Baicalein |
Baicalein（5,6,7-Trihydroxyflavone，Noroxylin，黄芩素）是一种存在于黄芩，木蝴蝶，百里香等植物中的天然黄酮类化合物，具有抗炎和抗癌活性。Baicalein可明显抑制PI3K/Akt/NF-κB途径，同时也可通过上调GPX4，抑制黑素细胞的铁死亡（ferroptosis），用于白癜风和肿瘤的相关研究。 |
| M9325
|
EGTA |
EGTA是一种特殊的钙离子螯合剂，在生理 pH 值 (7.4) 下，Kd 为 60.5 nM，对 Ca2+ 比对 Mg2+ 有很高的特异性。EGTA 显著抑制炎性巨噬细胞的底物粘附能力。 |
| M9330
|
Brij-35 |
Brij-35（月桂醇聚氧乙烯醚）是一种无毒的非离子表面活性剂，可降低非特定蛋白质的吸附，应用于红曲霉深层发酵时，能显著提高红曲色素产量。 |
| M6154
|
2-PMPA tetrasodium |
2-PMPA（PMPA tetrasodium salt）是高效选择性的谷氨酸羧肽酶II (GCPII)抑制剂，IC50值为300 pM。 |
| M2250
|
Pamidronate disodium |
Pamidronate Disodium（帕米膦酸二钠）是一种含氮的双磷酸盐类化合物，具有抑制骨吸收的作用，可用于癌症相关的溶骨性病变等研究。 |
| M9916
|
DPPH |
DPPH (2,2-Diphenyl-1-picrylhydrazyl，2,2-联苯基-1-苦基肼基) 是一种稳定的自由基，可用于测量抗氧化剂的自由基清除活性。 |
| M9194
|
Insulin (human) |
Insulin (human) 是一种多肽激素，其调节血液中的糖（葡萄糖）水平并且由胰岛的β细胞产生。 |
| M3409
|
Formestane |
Formestane（4-hydroxyandrostenedione，福美司坦）是第二代选择性芳香酶抑制剂，IC50为80 nM。 |
| M9665
|
N-(2-amino-2-oxoethyl)acrylamide |
N-(2-Amino-2-oxoethyl)acrylamide（N-acryloyl-glycinamide，丙烯酰基甘氨酰胺）是一种单体，其聚合物能制备水凝胶，并用于酶的固定化。 |
| M8230
|
2002-G12 |
2002-G12结合Aβ肽，抑制Aβ42诱导的PC12细胞的杀伤。 |
| M8229
|
Conessine |
Conessine is a plant steroid alkaloid that acts as a potent and specific antagonist of histamine H3 receptors (Ki = 5. |
| M8227
|
L-Dopa ethyl ester |
L-Dopa ethyl ester is a prodrug of levodopa that has greater gastric solubility. |
| M8226
|
MEGX |
Monoethylglycinexylidide (MEGX) is an active metabolite of lidocaine. |
| M8225
|
DiMNF |
DiMNF is a naphthoflavone derivative, selective aryl hydrocarbon receptor modulator (SAhRM). |
| M8224
|
1-Naphthohydroxamic Acid |
1-萘羟肟酸是一种细胞渗透性、强效和选择性组蛋白去乙酰化酶8 (HDAC8)抑制剂。 |
| M8220
|
NSC 33994 |
NSC 33994 is a potent and specific Jak2 inhibitor that inhibits a notorious mutation, Jak2-V617F, found in large number of myeloproliferative neoplasms. |
| M8219
|
CTP Inhibitor |
CTP Inhibitor is an inhibitor of mitochondrial citrate transport protein, was the first purely competitive inhibitor to be discovered and is more potent than BTC. |
| M8218
|
NB001 |
NB001, originally believed to be a selective inhibitor of adenylyl cyclase 1 (AC1), new evidence suggests NB001 does not interact with AC1 directly. |
| M8215
|
CP-101,606 |
Traxoprodil (CP-101,606) is a potent noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, selective for the NR2B subunit. |
| M8214
|
CGP 37849 |
CGP 37849 induces phencyclidine-like behavioral syndrome in amygdala-kindled rats that includes ataxia, locomotion and stereotypies. |
| M8212
|
MoTP |
MoTP (also known as 33N14) reversibly blocks the specification of neural crest cells into melanocytes in zebrafish studies. |
| M8210
|
FR-171113 |
FR171113 was the first non-peptide antagonist of the Protease Activated Receptor-1 (PAR1), also termed thrombin receptor. |
| M8209
|
Butyrylhydroxamic acid |
Butyryl hydroxamic acid is a cell permeable HDAC inhibitor. |
| M8208
|
4-Phenylbutyryl hydroxamic acid |
4-苯基丁基羟肟酸是一种细胞渗透性HDAC抑制剂，在9种HDAC酶中，它的效力大约是母体羧酸的100倍。 |
| M8207
|
IMB-10 |
IMB-10 is a ligand for the αMβ2 integrin that stabilizes the binding of the integrin to endogenous ligands such as proMMP-9 and fibrinogen. |
| M8206
|
PDI inhibitor 16F16 |
16F16是一种蛋白质二硫异构酶(PDI)抑制剂，首次在一种化合物的筛选中发现，该化合物可防止突变的杭丁顿蛋白诱导的凋亡。 |
| M8205
|
SR 142948A |
SR 142948A is a non-peptide Neurotensin receptor antagonist. |
| M8204
|
VAHA |
Hydroxamic acid derivatives of valproic acid exhibit anticonvulsant activity with no teratogenic activity in mouse neural tube defect model. |
| M8200
|
SB 220025 trihydrochloride |
SB 220025 is a potent, specific inhibitor of human p38 mitogen-activated protein (MAP) kinase, with an IC50 value of 60 nM and 50- to 1000-fold selectivity. |
