M2206
|
TH-302 (Evofosfamide) |
TH-302是一种选择性低氧激活的前体药物，靶向作用于实体瘤的hypoxic区域，IC50为19 nM，在缺氧条件下比在有氧条件下细胞毒性增强270倍，细胞色素P450代谢稳定。 |
| M6098
|
Baicalein |
Baicalein（5,6,7-Trihydroxyflavone，Noroxylin，黄芩素）是一种存在于黄芩，木蝴蝶，百里香等植物中的天然黄酮类化合物，具有抗炎和抗癌活性。Baicalein可明显抑制PI3K/Akt/NF-κB途径，同时也可通过上调GPX4，抑制黑素细胞的铁死亡（ferroptosis），用于白癜风和肿瘤的相关研究。 |
| M9325
|
EGTA |
EGTA是一种特殊的钙离子螯合剂，在生理 pH 值 (7.4) 下，Kd 为 60.5 nM，对 Ca2+ 比对 Mg2+ 有很高的特异性。EGTA 显著抑制炎性巨噬细胞的底物粘附能力。 |
| M9330
|
Brij-35 |
Brij-35（月桂醇聚氧乙烯醚）是一种无毒的非离子表面活性剂，可降低非特定蛋白质的吸附，应用于红曲霉深层发酵时，能显著提高红曲色素产量。 |
| M6154
|
2-PMPA tetrasodium |
2-PMPA（PMPA tetrasodium salt）是高效选择性的谷氨酸羧肽酶II (GCPII)抑制剂，IC50值为300 pM。 |
| M2250
|
Pamidronate disodium |
Pamidronate Disodium（帕米膦酸二钠）是一种含氮的双磷酸盐类化合物，具有抑制骨吸收的作用，可用于癌症相关的溶骨性病变等研究。 |
| M9916
|
DPPH |
DPPH (2,2-Diphenyl-1-picrylhydrazyl，2,2-联苯基-1-苦基肼基) 是一种稳定的自由基，可用于测量抗氧化剂的自由基清除活性。 |
| M9194
|
Insulin (human) |
Insulin (human) 是一种多肽激素，其调节血液中的糖（葡萄糖）水平并且由胰岛的β细胞产生。 |
| M3409
|
Formestane |
Formestane（4-hydroxyandrostenedione，福美司坦）是第二代选择性芳香酶抑制剂，IC50为80 nM。 |
| M9665
|
N-(2-amino-2-oxoethyl)acrylamide |
N-(2-Amino-2-oxoethyl)acrylamide（N-acryloyl-glycinamide，丙烯酰基甘氨酰胺）是一种单体，其聚合物能制备水凝胶，并用于酶的固定化。 |
| M8319
|
Eicosapentaenoyl ethanolamide |
Eicosapentaenoyl ethanolamide (EPEA) is a lipid mediator that has been found to suppress lifespan extension resulting from dietary restriction in C. |
| M8317
|
ALLO-1 |
allo1是一种Smoothened (Smo)拮抗剂，可以抑制野生型和突变型Smo，包括D473H突变型Smo。 |
| M8316
|
FMP-API-1 |
FMP-API-1 is an inhibitor of AKAP-PKA interactions in vitro and in cultured cardiac myocytes that activates PKA. |
| M8315
|
Ralfinamide mesylate |
Ralfinamide is a mixed sodium and N-type calcium channel blocker. |
| M8314
|
CGS 9895 |
CGS 9895 is a GABA antagonist that acts via the benzodiazepine binding site of ag containing GABA receptors. |
| M8312
|
NSC23925 |
NSC23925 is a specific Pgp1 inhibitor. |
| M8310
|
CHD-5 |
CHD-5 is a potent aryl hydrocarbon receptor antagonist. |
| M8309
|
VK3-OCH3 |
VK3-OCH3 is an analog of Vitamin K3 (Menadione) with potent antitumor activity. |
| M8308
|
Cipamfylline |
Cipamfylline is a PDE4 inhibitor that has been shown to cause a cellular redistribution of PDE4A4 into accretion foci, through an association with the ubiquitin scaffolding protein p62. |
| M8307
|
DIM-C-pPhtBu |
DIM-C-pPhtBu, similar to other C-DIMs, exhibits a broad range of anticancer and antitumorigenic activities against multiple tumor types. |
| M8305
|
Norgestimate |
Norgestimate is a synthetic progestin used in combination with estrogens as a contraceptive. |
| M8304
|
AA74-1 |
AA74-1是小鼠t细胞蛋白质组中丝氨酸水解酶酰基肽水解酶(APEH)的一种极有效的选择性抑制剂，其IC50为5 nM。 |
| M8302
|
CPDT |
CPTD (SNU2A) is a cytoprotective agent that protects mitochondria during cell stress by increasing antioxidant capacity. |
| M8301
|
MJC13 |
MJC13 inhibits the positive regulation of androgen receptor (AR) signaling by the cochaperone protein FKBP52. |
| M8300
|
A 887826 |
A-887826 is Nav1. |
| M8299
|
Methylstat |
Methylstat（甲基司他）是一种有效的组蛋白去甲基化酶（histone demethylases）抑制剂，可增加H3K27甲基化水平。它还具有抑制增殖、诱导凋亡以及诱导胞周期停滞等多种活性。 |
| M8298
|
Hydroxy-Dynasore |
Hydroxy-Dynasore is a cell permeable and potent dynamin inhibitor that prevents uptake of recombinant botulinum neurotoxin A heavy chain binding domain (BoNT/A-Hc). |
| M8297
|
S-Allyl-L-cysteine |
S-allyl-L-cysteine is a sulfur containing amino acid found in garlic with antioxidant, anti-cancer, antihepatotoxic, neuroprotective and neurotrophic activity. |
| M8296
|
DMPQ dihydrochloride |
DMPQ is a potent selective inhibitor of human vascular beta-type platelet derived growth factor receptor tyrosine kinase (PDGFR?) with IC50 = 80 nM. |
| M8295
|
Carcinine dihydrochloride |
Carcinine (β-alanyl histamine) is a selective histamine H3 antagonist, 100-1000-fold selective for H3 over H2 and H1, that also functions as an antioxidant and as a chemical chaperone to reduce non-enzymatic glycation of proteins. |
