M2206
|
TH-302 (Evofosfamide) |
TH-302是一种选择性低氧激活的前体药物，靶向作用于实体瘤的hypoxic区域，IC50为19 nM，在缺氧条件下比在有氧条件下细胞毒性增强270倍，细胞色素P450代谢稳定。 |
| M6098
|
Baicalein |
Baicalein（5,6,7-Trihydroxyflavone，Noroxylin，黄芩素）是一种存在于黄芩，木蝴蝶，百里香等植物中的天然黄酮类化合物，具有抗炎和抗癌活性。Baicalein可明显抑制PI3K/Akt/NF-κB途径，同时也可通过上调GPX4，抑制黑素细胞的铁死亡（ferroptosis），用于白癜风和肿瘤的相关研究。 |
| M9325
|
EGTA |
EGTA是一种特殊的钙离子螯合剂，在生理 pH 值 (7.4) 下，Kd 为 60.5 nM，对 Ca2+ 比对 Mg2+ 有很高的特异性。EGTA 显著抑制炎性巨噬细胞的底物粘附能力。 |
| M9330
|
Brij-35 |
Brij-35（月桂醇聚氧乙烯醚）是一种无毒的非离子表面活性剂，可降低非特定蛋白质的吸附，应用于红曲霉深层发酵时，能显著提高红曲色素产量。 |
| M6154
|
2-PMPA tetrasodium |
2-PMPA（PMPA tetrasodium salt）是高效选择性的谷氨酸羧肽酶II (GCPII)抑制剂，IC50值为300 pM。 |
| M2250
|
Pamidronate disodium |
Pamidronate Disodium（帕米膦酸二钠）是一种含氮的双磷酸盐类化合物，具有抑制骨吸收的作用，可用于癌症相关的溶骨性病变等研究。 |
| M9916
|
DPPH |
DPPH (2,2-Diphenyl-1-picrylhydrazyl，2,2-联苯基-1-苦基肼基) 是一种稳定的自由基，可用于测量抗氧化剂的自由基清除活性。 |
| M9194
|
Insulin (human) |
Insulin (human) 是一种多肽激素，其调节血液中的糖（葡萄糖）水平并且由胰岛的β细胞产生。 |
| M3409
|
Formestane |
Formestane（4-hydroxyandrostenedione，福美司坦）是第二代选择性芳香酶抑制剂，IC50为80 nM。 |
| M9665
|
N-(2-amino-2-oxoethyl)acrylamide |
N-(2-Amino-2-oxoethyl)acrylamide（N-acryloyl-glycinamide，丙烯酰基甘氨酰胺）是一种单体，其聚合物能制备水凝胶，并用于酶的固定化。 |
| M8295
|
Carcinine dihydrochloride |
Carcinine (β-alanyl histamine) is a selective histamine H3 antagonist, 100-1000-fold selective for H3 over H2 and H1, that also functions as an antioxidant and as a chemical chaperone to reduce non-enzymatic glycation of proteins. |
| M8294
|
Indazole-Cl |
Indazole-Cl is a selective estrogen receptor modifier (SERM), a selective ERβ agonist with > 100-fold selectivity for ERβ over Erα. |
| M8292
|
Cyamemazine |
Cyamemazine is a potent antagonist of 5-HT2C and 5-HT3 receptors with antipsychotic and anxiolytic properties. |
| M8291
|
Caramiphen hydrochloride |
Caramiphen is an anti-muscarinic similar to atropine; muscarinic acetylcholine receptor antagonist. |
| M8290
|
Aldi-2 |
Aldi-2是一种有效和特异性的共价醛脱氢酶抑制剂。 |
| M8289
|
HZ52 |
HZ52 is a dual inhibitor of mPGES and 5-lypoxygenase (Enzyme IC50 = 1. |
| M8288
|
CORM-A1 |
CORM-A1 is a water-soluble carbon monoxide (CO) releasing molecule that can be used to study the effects of CO on cellular systems. |
| M8287
|
CGP77675 |
CGP77675 is a potent Src kinase inhibitor. |
| M8283
|
Pleconaril |
Pleconaril is an orally bioavailable, broad-spectrum antipicorna-viral agent that binds to hydrophobic pocket in VP1 major capsid protein. |
| M8282
|
Deformylflustrabromine hydrochloride |
Desformylflustrabromine (dFBr) is a potent, selective positive allosteric modulator of α4β2 nicotinic receptor; increases efficacy and potency of acetylcholine. |
| M8280
|
PSNCBAM-1 |
PSNCBAM-1 is an allosteric, non-competitive antagonist of CB-1. |
| M8279
|
ABL127 |
ABL127是蛋白质磷酸酶甲基酯酶-1 (PME-1或PPME-1)的有效和选择性抑制剂。 |
| M8278
|
MLS000389544 |
MLS000389544 is a selective and potent methylsulfonylnitrobenzoate thyroid hormone receptor β (TRβ) antagonist that blocks the association of TRβ with steroid receptor coactivator 2 (SRC2). |
| M8275
|
LG100268 |
LG100268 (LG268) is a potent and selective rexinoid and retinoid-X receptor (RXR) agonist. |
| M8273
|
NSC 162535 disodium salt |
NSC 162535 is an inhibitor of RNA editing in trypanosomatid pathogens that results from lost of the interaction of core editosome with substrate RNA. |
| M8271
|
GSK575594A |
GSK575594A is a selective agonist of human GPR55. |
| M8270
|
2OHOA |
2OHOA可诱导神经胶质瘤、白血病、乳腺癌和结肠癌等多种肿瘤细胞周期阻滞和凋亡。 |
| M8268
|
4-MDM |
4-MDM增加了LTA4水解酶的氨基肽酶活性，而不影响LTA4向LTB4的转化。 |
| M8267
|
Anisodamine |
Anisodamine is a muscarinic receptor antagonist. |
| M8266
|
ML169 |
ML169 is a positive allosteric modulator (PAM) of the muscurinic acetycholine receptor M1 (CHRM1). |
