M2206
|
TH-302 (Evofosfamide) |
TH-302是一种选择性低氧激活的前体药物，靶向作用于实体瘤的hypoxic区域，IC50为19 nM，在缺氧条件下比在有氧条件下细胞毒性增强270倍，细胞色素P450代谢稳定。 |
| M6098
|
Baicalein |
Baicalein（5,6,7-Trihydroxyflavone，Noroxylin，黄芩素）是一种存在于黄芩，木蝴蝶，百里香等植物中的天然黄酮类化合物，具有抗炎和抗癌活性。Baicalein可明显抑制PI3K/Akt/NF-κB途径，同时也可通过上调GPX4，抑制黑素细胞的铁死亡（ferroptosis），用于白癜风和肿瘤的相关研究。 |
| M9325
|
EGTA |
EGTA是一种特殊的钙离子螯合剂，在生理 pH 值 (7.4) 下，Kd 为 60.5 nM，对 Ca2+ 比对 Mg2+ 有很高的特异性。EGTA 显著抑制炎性巨噬细胞的底物粘附能力。 |
| M9330
|
Brij-35 |
Brij-35（月桂醇聚氧乙烯醚）是一种无毒的非离子表面活性剂，可降低非特定蛋白质的吸附，应用于红曲霉深层发酵时，能显著提高红曲色素产量。 |
| M6154
|
2-PMPA tetrasodium |
2-PMPA（PMPA tetrasodium salt）是高效选择性的谷氨酸羧肽酶II (GCPII)抑制剂，IC50值为300 pM。 |
| M2250
|
Pamidronate disodium |
Pamidronate Disodium（帕米膦酸二钠）是一种含氮的双磷酸盐类化合物，具有抑制骨吸收的作用，可用于癌症相关的溶骨性病变等研究。 |
| M9916
|
DPPH |
DPPH (2,2-Diphenyl-1-picrylhydrazyl，2,2-联苯基-1-苦基肼基) 是一种稳定的自由基，可用于测量抗氧化剂的自由基清除活性。 |
| M9194
|
Insulin (human) |
Insulin (human) 是一种多肽激素，其调节血液中的糖（葡萄糖）水平并且由胰岛的β细胞产生。 |
| M3409
|
Formestane |
Formestane（4-hydroxyandrostenedione，福美司坦）是第二代选择性芳香酶抑制剂，IC50为80 nM。 |
| M9665
|
N-(2-amino-2-oxoethyl)acrylamide |
N-(2-Amino-2-oxoethyl)acrylamide（N-acryloyl-glycinamide，丙烯酰基甘氨酰胺）是一种单体，其聚合物能制备水凝胶，并用于酶的固定化。 |
| M8356
|
ES936 |
ES936 is a very potent and selective inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1). |
| M8353
|
SPA0355 |
SPA0355 inhibits cytokine and LPS-induced activation of NF-kB in cell-based assays, blocking IKK-2 phosphorylation, degradation, and p65 binding to DNA. |
| M8352
|
BPD |
BPD通过失活TAK-1抑制lps诱导的NF-kB信号转导。 |
| M8350
|
Methylhexanamine hydrochloride |
Methylhexanamine is a naturally substance isolated from Pelargonium graveolen. |
| M8349
|
AE9C90CB |
AE9C90CB是一种毒蕈碱型乙酰胆碱受体拮抗剂，M3受体亚型比M2有20倍的选择性。 |
| M8347
|
SM-7368 |
SM-7368 is a cell-permeable inhibitor of TNF-α-induced MMP-9 upregulation. |
| M8346
|
AZ513 |
AZ513是一种可逆的、非竞争性的FAAH抑制剂。 |
| M8343
|
BNS-22 |
BNS-22是从Calophyllum brasiliense的茎皮中分离得到的天然产物GUT-70的衍生物，对人类癌细胞具有抗增殖活性。 |
| M8341
|
PQ1 succinate |
PQ1 binds tightly to connexin 43 and activates intracellular gap junctions. |
| M8339
|
Cardionogen-2 |
Cardionogen-2 is a biphasic modulator of cardiogenesis that enlarges the size of the zebrafish embryonic heart by promoting cardiomyocyte formation. |
| M8338
|
NPD4456 |
NPD4456 is an HIV-1 Vpr inhibitor that directly binds to HIV-1 Vpr. |
| M8337
|
ST247 |
ST247 is a PPAR β/δ selective inverse agonist. |
| M8334
|
FQI1 |
FQI1 inhibits the DNA-binding activity of LSF, a ubiquitous transcription factor that is up regulated in many hepatocellular carcinomas (HCC). |
| M8333
|
IM-54 |
IM-54 is a cell permeable, potent and selective inhibitor of necrosis. |
| M8332
|
PT-S58 |
PT-S58 is a PPAR β/δ full antagonist, and a derivative of GSK0660. |
| M8330
|
Carboxyamidotriazole |
Carboxyamidotriazole (L-651582) is an orally active calcium channel blocker. |
| M8328
|
RBx-0597 |
RBx-0597 is a potent, competitive inhibitor of DPP-IV (IC50 = 30 nM), that displays selectivity or 150 and 300 fold over DDP-VIII and DDP-IX, respectively. |
| M8326
|
Salsolinol hydrobromide |
Salsolinol is the condensation product of acetaldehyde and dopamine. |
| M8325
|
DR2313 |
DR2313 is a PARP-1; PARP-2 inhibitor (Ki = 0. |
| M8320
|
CUR61414 |
CUR61414 specifically binds to, and antagonizes the activity of smoothened (Smo) in the hedgehog signaling pathway. |
