找到约 33 条 “P-glycoprotein” 相关结果 （用时 0.169 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M21644
|
Recombinant Human Fetuin A (Mammalian, C-6His) | 重组人Fetuin A蛋白 (Mammalian, C-6His) | Recombinant Proteins |
| FETUA; AHSG; Alpha-2-HS-Glycoprotein | |||
| 重组人(Fetuin)胎球蛋白 A (C-6His) 是一种糖蛋白，由 A 链和 B 链两个亚基组成，属于蛋白酶抑制剂的胱抑素家族。它在胚胎细胞和成体肝细胞中高表达，在单核细胞/巨噬细胞中表达较少。AHSG 是体内钙化的重要循环抑制剂，在急性期反应期间下调。它涉及多种功能，例如内吞作用、大脑发育和骨组织的形成。 | |||
| M51671 | HHV-2 Envelope Glycoprotein G (552-574) | HHV-2 Envelope Glycoprotein G (552-574) | Others |
| HHV-2 包膜糖蛋白 G (552-574) 是糖蛋白 G (gG-2) 的免疫显性区域，可与所有单纯疱疹 (HSV-2) 血清反应。 | |||
| M53455 | FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578) | FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578) | Anti-infection |
| FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578) 是一种 FITC 标记的 HHV-2 Envelope Glycoprotein G (561-578)。 | |||
| M1845
|
LY335979 trihydrochloride | LY335979 trihydrochloride | P-glycoprotein |
| Zosuquidar trihydrochloride | |||
| Zosuquidar (LY335979) 3HCl是一种有效的P-glycoprotein（P-糖蛋白）介导的多药耐抗性的调节剂，Ki为60 nM。 | |||
| M1888
|
Tariquidar | 他芮喹达 | P-glycoprotein |
| XR9576 | |||
| Tariquidar是一种有效的，选择性的，非竞争性P-glycoprotein（p-糖蛋白）抑制剂，Kd为5.1 nM，作用于MDR细胞系，可以逆转耐药性。 | |||
| M40805
|
Recombinant Human TPO (Mammalian, N,C-6His) | 重组人TPO (Mammalian, N,C-6His) | Recombinant Proteins |
| Thrombopoietin; THPO | |||
| Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. | |||
| M4886
|
Selamectin | 塞拉菌素;司拉克丁 | Parasite |
| Selamectin是一种抗寄生虫剂和驱虫剂，能激活神经元和咽肌中的谷氨酸门控氯离子通道 (glutamate-gated chloride channels)，以预防恶丝虫、淋巴丝虫和线虫感染。Selamectin 还是一种有效的 P-糖蛋白 (P-glycoprotein) 底物和抑制剂，IC50 为 120 nM。 | |||
| M5881
|
Piperine | 胡椒碱 | P-glycoprotein |
| Bioperine; 1-Piperoylpiperidine | |||
| Piperine是从胡椒中分离的天然生物碱，可以抑制P-glycoprotein and CYP3A4的活性，在HeLa细胞中的IC50值为61.94±0.054 μg/mL。 | |||
| M5935
|
Risperidone | 利培酮 | 5-HT Receptor |
| R-64766 | |||
| Risperidone是 5-HT2 受体的阻断剂，P-糖蛋白 (P-Glycoprotein) 的抑制剂 和 dopamine D2 受体的拮抗剂，其对 5-HT2A 和 dopamine D2 受体的 Ki 值分别为 4.8，5.9 nM。可用于精神分裂症的相关研究。 | |||
| M8724 | NSC73306 | NSC73306 | Others |
| NSC73306, a thiosemicarbazone, is a cell penetrant, cytotoxic agent that exhibits greater toxicity against cells expressing functional P-gp (P-glycoprotein) than against other cells. | |||
| M10009
|
Recombinant Human Apo-transferrin Protein | 重组人Transferrin(脱铁)蛋白 | Recombinant Proteins |
| Transferrin is iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids. | |||
| M10016
|
Recombinant Rat EGF Protein (CHO) | 重组大鼠EGF蛋白 (CHO) | Recombinant Proteins |
| Epidermal Growth Factor | |||
| Recombinant Rat EGF Protein is type Itransmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. | |||
| M31298
|
Recombinant Human CRHBP (Mammalian, C-6His) | 重组人CRHBP (Mammalian, C-6His) | Recombinant Proteins |
| CRFBP; CRF-Binding Protein; Corticotropin-Releasing Hormone-Binding Protein | |||
| Corticotropin-Releasing Factor-Binding Protein (CRHBP) is a 37 kDa secreted glycoprotein that binds both CRH and urocortin in a 42 kDa extracellular complex. CRHBP may inactivate CRH and may prevent inappropriate pituitary-adrenal stimulation in pregnancy. | |||
| M10652
|
Voacamine | 老刺木胺 | Cannabinoid |
| Voacamine is an indole alkaloid, exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells. | |||
| M54865
|
Recombinant Human EpCAM/Trop-1 (Mammalian, C-Fc) | 重组人EpCAM (Mammalian, C-Fc) | Recombinant Proteins |
| CD326 | |||
| Epithelial Cell Adhesion Molecule (EpCAM) is a signal type I transmembrane glycoprotein. EpCAM plays a role in embryonic stem cells proliferation and differentiation; it up-regulates the expression of FABP5, MYC and Cyclin A and Cyclin E. It is highly and selectively expressed by undifferentiated embryonic stem cells. | |||
| M13474 | Pristinamycin IA | Pristinamycin IA | Antibiotic |
| Mikamycin B; Mikamycin IA | |||
| Pristinamycin IA (Mikamycin B，Mikamycin IA) 是一个环肽大环内酯抗生素，属于 链霉杀阳菌素，也是P-glycoprotein的底物。 | |||
| M14249
|
Encequidar | Encequidar | P-glycoprotein |
| HM30181; HM30181A | |||
| Encequidar (HM30181; HM30181A) 是一种有效的选择性的P-glycoprotein抑制剂。 | |||
| M14250
|
Encequidar mesylate | Encequidar mesylate | P-glycoprotein |
| HM30181 mesylate; HM30181A mesylate | |||
| Encequidar mesylate (HM30181 mesylate; HM30181A mesylate) 是P-糖蛋白 (P-glycoprotein) 的有效竞争性抑制剂。 | |||
| M14251 | Tariquidar methanesulfonate, hydrate | Tariquidar methanesulfonate, hydrate | P-glycoprotein |
| XR9576 methanesulfonate, hydrate | |||
| Tariquidar methanesulfonate, hydrate (XR9576 methanesulfonate, hydrate) 是有效和特异性的 P-glycoprotein (P-gp) 抑制剂，Kd值为5.1 nM。 | |||
| M14818
|
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA | Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA | Peptides |
| MOG (35-55) (TFA) | |||
| Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (TFA) 是中枢神经鞘的一个次要成分。Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (TFA)引发复发缓解性神经系统疾病，伴有广泛的斑块样脱髓鞘。还能诱导强效的 T细胞和 B 细胞反应，同时是高度脑源性的。 | |||
| M19333 | Roemerine | 莲碱 | P-glycoprotein |
| Roemerine 是可从 Fibraurea recisa Pierre 叶子中分离得到的一种生物碱、通过P-glycoprotein 发挥作用。Roemerine 可逆转培养细胞的多药耐药表型。 | |||
| M20860 | Eptifibatide Acetate | Eptifibatide Acetate | Others |
| Mpr-Har-Gly-Asp-Trp-Pro-Cys-NH2 | |||
| Eptifibatide Acetate is a cyclic heptapeptide constructed from 6 amino acids and a mercaptopropionyl residue. A disulfide bridge forms between mercaptopropionyl and cysteine. Eptifibatide prevents platelet aggregation. One study shows the inhibition of platelet glycoprotein IIb/IIIa in acute coronary syndromes. | |||
| M21670
|
Recombinant Mouse/Rat VEGF-C Protein (HEK293, aa 108-223, Fc Tag) | 重组小鼠/大鼠VEGF-C蛋白 (HEK293, aa 108-223, Fc Tag) | Recombinant Proteins |
| Vascular endothelial growth factor C | |||
| Recombinant Mouse/Rat VEGF-C Protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC), the ED50 is typically 70-300 ng/mL. | |||
| M21671
|
Recombinant Mouse/Rat VEGF-C Protein (HEK293, aa 108-223, His Tag) | 重组小鼠/大鼠VEGF-C蛋白 (HEK293, aa 108-223, His Tag) | Recombinant Proteins |
| Vascular endothelial growth factor C | |||
| Recombinant Mouse/Rat VEGF-C Protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC), the ED50 for this effect is typically 0.1-0.8 μg/mL. | |||
| M24887 | Torapsel | Torapsel | Others |
| 42-89-glycoprotein; WAY164339; pMT21:PL85 | |||
| Torapsel (42-89-glycoprotein; WAY164339) 是一种与免疫球蛋白融合的蛋白。Torapsel 可用于研究缺血再灌注损伤的预防。 | |||
| M25440
|
Recombinant Human Osteopontin/SPP1 Protein (Mammalian, C-6His) | 重组人Osteopontin/SPP1蛋白 (Mammalian, C-6His) | Recombinant Proteins |
| OPN; Secreted Phosphoprotein 1 | |||
| Osteopontin/SPP1 is a secreted multifunctional glycoprotein. Its putative functions include roles in bone metabolism, immune regulation, wound healing, cell survival, and tumor progression. Osteopontin/SPP1 acts as a cytokine that is involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10. | |||
| M29072 | Laniquidar | Laniquidar | P-glycoprotein |
| R101933 | |||
| Laniquidar (R101933) 是一种非竞争性的第三代 P-glycoprotein (P-gp) 抑制剂，IC50值为 0.51 μM。Laniquidar 可用于多药耐药转运体的调控。Laniquidar 也可用于研究急性髓细胞白血病 (AML) 和骨髓增生异常综合征 (MDS)。Laniquidar口服生物利用度有限。 | |||
| M29083 | Furanodiene | 莪术呋喃二烯 | ROS |
| Furanodiene 是从姜黄中提取的天然萜类化合物。Furanodiene 通过抗血管生成和诱导 ROS 产生，DNA 链断裂和细胞凋亡发挥抗癌作用。Furanodiene 抑制外排转运蛋白 Pgp (P-glycoprotein) 功能并降低 Pgp 蛋白水平。 | |||
| M30448 | Risperidone hydrochloride | Risperidone hydrochloride | 5-HT Receptor |
| R 64 766 hydrochloride | |||
| Risperidone hydrochloride (R 64 766 hydrochloride) 是 5-HT2 受体的阻断剂，P-糖蛋白 (P-Glycoprotein) 的抑制剂 和 dopamine D2 受体的拮抗剂，其对 5-HT2A 和 dopamine D2 受体的 Ki 值分别为 4.8，5.9 nM。 | |||
| M30449 | Risperidone mesylate | Risperidone mesylate | 5-HT Receptor |
| R 64 766 mesylate | |||
| Risperidone mesylate(R 64 766 mesylate) 是 5-HT2 受体的阻断剂，P-糖蛋白 (P-Glycoprotein) 的抑制剂 和 dopamine D2 受体的拮抗剂，其对 5-HT2A 和 dopamine D2 受体的 Ki 值分别为 4.8，5.9 nM。 | |||
| M31176
|
Recombinant Human CD40L Protein (E. coli) | 重组人CD40L蛋白 (E. coli) | Recombinant Proteins |
| CD40 Ligand; CD154; TRAP | |||
| CD40 Ligand (CD40L/CD154/TRAP) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. The CD40 ligand stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. Recombinant Human CD40 Ligand is produced by E.coli expression system and the target gene encoding Met113-Leu261 is expressed. | |||
| M39037 | Phellamurin | Phellamurin | P-glycoprotein |
| Phellamurin 是一种来自 Phellodendron amurense 叶的植物黄酮糖苷，可抑制肠道 P-糖蛋白 (P-glycoprotein)。Phellamurin 还抑制凤蝶的产卵。 | |||
| M40606
|
Recombinant Human C5a Protein (E.coli) | 重组人补体C5a (E.coli) | Recombinant Proteins |
| Complement C5; C5a anaphylatoxin | |||
| Human Complement 5a (C5a) is an enzymatically generated glycoprotein that belongs to a family of structurally and functionally related proteins known as anaphylatoxins. Recombinant Human C5a expressed the target gene encoding Thr678-Arg751. | |||
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