找到约 58 条 “INH6” 相关结果 （用时 0.278 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M2114
|
GSK126 | GSK126 | EZH2 |
| EZH2 inhibitor; GSK2816126A | |||
| GSK126是一种高活性，S-腺苷-蛋氨酸竞争性EZH2甲基转移酶抑制剂，Ki为0.5 nM。 | |||
| M2659
|
E-64 | E-64 | Autophagy |
| Proteinase inhibitor E 64 | |||
| E-64 是一种选择性的，不可逆的，作用于木瓜蛋白酶的半胱氨酸蛋白酶（Cathepsin）抑制剂，其IC50为9 nM。同时还可以阻断自噬（autophagy），并引起中央液泡中自溶体和/或许多细胞质内含物的积累。 | |||
| M2785
|
JNK Inhibitor IX (SC202671) | JNK Inhibitor IX (SC202671) | JNK |
| TCS JNK 5a; SC-202671 | |||
| JNK inhibitor IX 是一种高度选择性JNK抑制剂，其作用于JNK2和JNK3的pIC50分别为6.5和6.7。 | |||
| M5282
|
INH6 | INH6 | Microtubule |
| INH6 是强效的Hec1抑制剂, 其特异性地破坏Hec1/Nek2相互作用，并导致染色体排列异常。 | |||
| M8206 | PDI inhibitor 16F16 | PDI inhibitor 16F16 | Others |
| 16F16是一种蛋白质二硫异构酶(PDI)抑制剂，首次在一种化合物的筛选中发现，该化合物可防止突变的杭丁顿蛋白诱导的凋亡。 | |||
| M9642
|
EGFR inhibitor 324674 | EGFR inhibitor 324674 | EGFR/HER2 |
| EGFR-IN-12 | |||
| EGFR inhibitor 324674 is a cell permeable, potent and selective EGFR inhibitor with IC50 of 21 nM. | |||
| M14255 | IK1 inhibitor PA-6 | IK1 inhibitor PA-6 | Potassium Channel |
| PA-6 | |||
| IK1 inhibitor PA-6 (PA-6) 是一种喷他脒类似物，是有效的、选择性的 IK1 (KIR2.x离子通道携带向内整流电流) 抑制剂，人和老鼠中对KIR2.x 电流的 IC50 值为 12-15 nM。 | |||
| M14905
|
PKA Inhibitor Fragment (6-22) amide TFA | PKA Inhibitor Fragment (6-22) amide TFA | PKA |
| PKI-(6-22)-amide TFA | |||
| PKA Inhibitor Fragment (6-22) amide TFA 是 cAMP 依赖性蛋白激酶 A (PKA) 的抑制剂，Ki 值为 2.8 nM。PKA Inhibitor Fragment (6-22) amide TFA 可显着逆转小鼠低水平的吗啡缓解疼痛的感受性。 | |||
| M20596 | K-Ras(G12C) inhibitor 6 | K-Ras(G12C) inhibitor 6 | ROCK |
| K-Ras(G12C) inhibitor 6 is an allosteric, and selective inhibitor of oncogenic K-Ras(G12C). | |||
| M20680
|
IRAK inhibitor 6 | IRAK inhibitor 6 | IRAK |
| IRAK inhibitor 6是一种选择性的白细胞介素-1 受体相关激酶 4（IRAK4）抑制剂，IC50 为 0.16 μM。 | |||
| M20707
|
RK 24466 | RK 24466 | Src-bcr-Abl |
| KIN 001-51, Lck inhibitor C 8863, C8863 | |||
| RK-24466 (KIN 001-51) is a potent and selective inhibitor of Lck that inhibits two constructs of the human lck kinase, lck (64-509) and lckcd with IC50 of < 0.001 μM and 0.002 μM, respectively. | |||
| M22513 | Mcl-1 inhibitor 6 | Mcl-1抑制剂6 | Bcl-2 |
| Mcl-1 inhibitor 6 是一种口服有效的，选择性的骨髓细胞白血病 1 (Mcl-1) 蛋白抑制剂，Kd 值为 0.23 nM，Ki 值为 0.02 μM。Mcl-1 inhibitor 6 对 Mcl-1 的选择性高于其他 Bcl-2 家族成员 (Bcl-2、Bcl2A1、Bcl-xL 和 Bcl-w，Kd>10 μM)。 | |||
| M27728 | Tubulin inhibitor 6 | Tubulin inhibitor 6 | Microtubule |
| Tubulin inhibitor 6 (Compound 14b) 是一种微管蛋白 (tubulin) 抑制剂，也是多种肿瘤细胞系的有效抑制剂。Tubulin inhibitor 6 抑制微管蛋白聚合，IC50 为 0.87 μM。Tubulin inhibitor 6 抑制 K562 细胞生长，IC50 为 840 nM。 | |||
| M29486 | SHP2 inhibitor LY6 | SHP2 inhibitor LY6 | Phosphatase |
| LY6 | |||
| SHP2 inhibitor LY6 (LY6) 是一种有效和选择性的 SHP2 抑制剂，IC50 值为 9.8 µM。SHP2 inhibitor LY6 可以抑制 SHP2 介导的细胞信号传导和增殖。 | |||
| M29603 | FAK inhibitor 6 | FAK inhibitor 6 | FAK |
| 化合物26f不仅优化了有效抑制酶（IC50= 28.2 nM），也表现出相对较少的细胞毒性（IC50= 3.32 μM），并以剂量依赖性方式诱导MDA-MB-231细胞凋亡，有效阻断G0/G1期MDA-MB-231细胞。 | |||
| M30630
|
p32 Inhibitor M36 | p32 Inhibitor M36 | PKC |
| M36 | |||
| p32 inhibitor M36 (M36) 是一种 p32 线粒体蛋白小分子抑制剂，可直接与 p32 结合，抑制 p32 与 LyP-1 的结合。 | |||
| M40641
|
Recombinant Mouse MIF Protein (E.coli, C-6His) | 重组小鼠MIF蛋白 (E.coli, C-6His) | Cytokines and Growth Factors |
| Macrophage migration inhibitory factor; DER6 | |||
| Macrophage migration inhibitory factor (MIF) is a secreted protein and belongs to the MIF family. MIF is an important regulator of innate immunity. The circulating MIF binds to CD74 on other immune cells to trigger an acute immune response. Hence MIF is classified as an inflammatory cytokine. Furthermore glucocorticoids also stimulate white blood cells to release MIF and hence MIF partially counter acts the inhibitory effects that glucocorticoids have on the immune system. Finally trauma activates the anterior pituitary gland to release MIF. | |||
| M41038 | Tuberculosis inhibitor 6 | Tuberculosis inhibitor 6 | Antibiotic |
| Tuberculosis inhibitor 6 是一种 3-甲氧基-2-苯基咪唑并[1,2-b]哒嗪衍生物，对结核分枝杆菌 (MIC90 ≤1.66 μM) 和海洋分枝杆菌 (MIC90 为 2.65 μM) 表现出高度活性。 | |||
| M41318 | Mcl-1 inhibitor 16 | Mcl-1 inhibitor 16 | Bcl-2 |
| Mcl-1 inhibitor 16 是一种基于铂的线粒体靶向 Mcl-1 抑制剂。 | |||
| M41410 | ATM Inhibitor-6 | ATM Inhibitor-6 | ATM/ATR |
| ATM Inhibitor-6 (A-193) 是选择性的 ATM 激酶抑制剂。 | |||
| M41520 | Tubulin inhibitor 36 | Tubulin inhibitor 36 | Microtubule |
| Tubulin inhibitor 36 是一种新型的强效微管蛋白抑制剂，可抑制微管蛋白的聚合并诱导细胞凋亡，其 IC50 值为 1.5±0.1 μM。 | |||
| M41601 | SIRT5 inhibitor 6 | SIRT5 inhibitor 6 | Sirtuin |
| SIRT5 Inhibitor 6 是一种有效的、具有底物竞争性和选择性的 SIRT5 抑制剂，IC50 为 3.0 μM。 | |||
| M41609 | Topoisomerase II inhibitor 16 | Topoisomerase II inhibitor 16 | Topoisomerase |
| Topoisomerase II inhibitor 16 是一种选择性、具有口服活性、可透过血脑屏障及不可逆的锥虫拓扑异构酶 II (trypanosomal topoisomerase II) 抑制剂，可稳定双链 DNA：酶裂解复合物。 | |||
| M42104 | Pim-1 kinase inhibitor 6 | Pim-1 kinase inhibitor 6 | Pim |
| Pim-1 kinase inhibitor 6 是一种有效的 Pim-1 激酶抑制剂，其 IC50 值为 0.46 μM，对癌细胞具有显着的细胞毒性作用。 | |||
| M42117 | KRAS G12C inhibitor 61 | KRAS G12C inhibitor 61 | ERK |
| KRAS G12C inhibitor 61 抑制 MIA PaCa-2 细胞中的 ERK 1/2 磷酸化，IC50 值为 9 nM。 | |||
| M42125 | JNK3 inhibitor-6 | JNK3 inhibitor-6 | JNK |
| JNK3 inhibitor-6 是一种选择性的 JNK3 抑制剂 (IC50=78 nM)。 | |||
| M42269 | URAT1 inhibitor 6 | URAT1 inhibitor 6 | URAT1 |
| URAT1 inhibitor 6 是一种有效的 URAT1 抑制剂 (对hURAT1 的 IC50 为 35 nM)。 | |||
| M42392 | sEH inhibitor-16 | sEH inhibitor-16 | Epoxide Hydrolase |
| sEH inhibitor-16 是一种可溶性环氧化物水解酶 (sEH) 抑制剂，IC50 值为 2 nM。 | |||
| M45288 | Casein Kinase inhibitor A86 | Casein Kinase inhibitor A86 | Casein Kinase |
| Casein Kinase inhibitor A86是一种有效且具有口服活性的酪蛋白激酶 1α (CK1α) 抑制剂，同时还能抑制 CDK7 (TFIIH) 和 CDK9 (P-TEFb)。此外，Casein Kinase inhibitor A86 也可诱导白血病细胞凋亡 (apoptosis)，可用于白血病的相关研究。 | |||
| M49704 | ERK1/2 inhibitor 6 | ERK1/2 inhibitor 6 | ERK |
| ERK1/2 inhibitor 6 是一种有效的ERK1/2抑制剂。 | |||
M2497
|
Cathepsin Inhibitor 1 | Cathepsin Inhibitor 1 | Cathepsin |
| Cathepsin Inhibitor 1是一种组织蛋白酶(L，L2，S，K，B)的抑制剂，pIC50分别为7.9，6.7，6.0，5.5，5.2。 | |||
| M2830
|
Mdivi-1 | Mdivi-1 | Dynamin |
| Mitochondrial division inhibitor 1 | |||
| Mdivi-1（Mitochondrial division inhibitor 1）是一种动力蛋白相关蛋白1 (Drp1)的GTP酶抑制剂，可调节线粒体动力蛋白的表达，IC50为10 μM。同时能抑制NF-κB信号通路和NLRP3炎症小体的激活。此外，mdivi-1还可通过浓度依赖性的方式，降低快速激活延迟整流K⁺电流(I(Kr))的尾电流(I(tail))的振幅，其IC₅₀值为11.6 μM。Mdivi-1 是一种有效的线粒体分裂/线粒体自噬 (mitophagy) 抑制剂。 | |||
| M3634
|
TAPI-1 | TAPI-1 | Immunology/Inflammation |
| TAPI-1（TNF-α processing inhibitor-1）是一种ADAM17/TACE(TNF-α转化酶)抑制剂，可通过抑制TACE 介导的可溶性TNF-α及其受体的释放，从而减少其他炎症因子的产生。此外，TAPI-1能在稳定表达M3毒蕈碱受体的HEK-293细胞中，减少组成型和毒蕈碱受体刺激的sAPP释放，IC50分别为8.09 μM和3.61 μM，可用于关节炎的相关研究， | |||
| M4909
|
GSK2801 | GSK2801 | Epigenetic Reader Domain |
| GSK2801 is a selective bromodomains BAZ2A/B inhibitor with KD of 257 nM and 136 nM, respectively. | |||
| M4937
|
Icotinib Hydrochloride | 盐酸埃克替尼 | EGFR/HER2 |
| BPI-2009H | |||
| Icotinib Hcl(BPI-2009H) is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with an IC(50) of 5 nM, including it's mutants of EGFR(L858R), EGFR(L861Q), EGFR(T790M) and EGFR(T790M, L858R). | |||
| M5136
|
GSK-LSD1 dihydrochloride | GSK-LSD1 dihydrochloride | Histone demethylase |
| GSK-LSD1 2HCl | |||
| GSK-LSD1 2HCl is an irreversible, and selective LSD1 inhibitor with IC50 of 16 nM, > 1000 fold selective over other closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B). | |||
| M58584
|
(E)-Akt inhibitor-IV | (E)-Akt inhibitor-IV | Akt |
| CS-1992 | |||
| (E)-Akt inhibitor-IV 是一种 PI3K-Akt 抑制剂，具有显著的细胞毒性。(E)-Akt inhibitor-IV 对四种细胞系 (MDA-MB468 细胞、MDA-MB231 细胞、MCF7 细胞和 184B5 细胞) 的平均 GI20 为 0.04 μM。 | |||
| M7346
|
T16Ainh-A01 | T16Ainh-A01 | Chloride Channel |
| T16Ainh-A01 是一种Ca2+激活的Cl-通道跨膜蛋白16A（TMEM16A）抑制剂。 | |||
| M7417 | TNP | TNP | Others |
| TNP is a inhibitor of IP6K; also inhibits IP3K. | |||
| M7627
|
BIO | (2'Z,3'E)-6-溴靛玉红-3'-肟 | GSK-3 |
| 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime6BIO; GSK 3 IX; GSK 3 Inhibitor IX; MLS 2052 | |||
| BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052)是一种特异性的GSK-3抑制剂，无细胞试验中作用于GSK-3α/β的IC50为5 nM，比作用于CDK5选择性高16倍以上，也是一种泛JAK抑制剂，对 Tyk2 的IC50值为30 nM。BIO 可在人类黑色素瘤细胞中诱导凋亡。此外，BIO在无外源Sox2下，可以两因子诱导MEFs，并且也是2i诱导的成分之一，可增强多能性相关基因的表达 | |||
| M7731 | CHIC-35 | CHIC-35 | Others |
| CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. | |||
| M7872
|
Kojic acid | 曲酸 | NF-κB |
| Tyrosinase inhibitor（曲酸）是一种从真菌中分离出来的天然产物。也是NF-κb，儿茶酚氧化酶，酪氨酸酶和D-氨基酸氧化酶的抑制剂。抑制蘑菇酪氨酸酶的IC50值为6.1±0.4 μg/ml，具有抗肿瘤功能。 | |||
| M8200 | SB 220025 trihydrochloride | SB 220025 trihydrochloride | Others |
| SB 220025 is a potent, specific inhibitor of human p38 mitogen-activated protein (MAP) kinase, with an IC50 value of 60 nM and 50- to 1000-fold selectivity. | |||
| M8220 | NSC 33994 | NSC 33994 | Others |
| NSC 33994 is a potent and specific Jak2 inhibitor that inhibits a notorious mutation, Jak2-V617F, found in large number of myeloproliferative neoplasms. | |||
| M8308 | Cipamfylline | 西潘茶碱 | Others |
| Cipamfylline is a PDE4 inhibitor that has been shown to cause a cellular redistribution of PDE4A4 into accretion foci, through an association with the ubiquitin scaffolding protein p62. | |||
| M8353 | SPA0355 | SPA0355 | Others |
| SPA0355 inhibits cytokine and LPS-induced activation of NF-kB in cell-based assays, blocking IKK-2 phosphorylation, degradation, and p65 binding to DNA. | |||
| M8377 | UCM710 | UCM710 | Others |
| UCM710 is a dual inhibitor of fatty acid amide hydrolase (FAAH) and α/β hydrolase domain 6 (ABHD6) the enzymes that hydrolyze endocannabinoids. | |||
| M8382
|
kb-NB142-70 | kb-NB142-70 | Others |
| kb-NB142-70 is a derivative of the PKD1 inhibitor CID755673, with approximately 6-fold greater potency (IC50 for inhibition of PKD1 = 28. | |||
| M8459 | CD40-TRAF6 signaling inhibitor | CD40-TRAF6 signaling inhibitor | Others |
| CD40-TRAF6 signaling inhibitor is a small molecule that binds to TRAF6, blocking interactions with CD40. | |||
| M8480 | KT182 | KT182 | Others |
| KT182 is a very potent, orally bioavailable, selective inhibitor of ABHD6 (a/b-Hydrolase Domain Containing 6). | |||
| M8481 | KT203 | KT203 | Others |
| KT203 is a very potent, selective inhibitor of ABHD6 (IC50 = 0. | |||
| M8594
|
BRD3308 | BRD3308 | HDAC |
| BRD3308 is a highly selective inhibitor of histone deacetylase 3 (HDAC3) with an IC50 value of 65 nM for HDAC3 vs. | |||
| M8596 | WWL70 | WWL70 | Others |
| WWL70 is a selective inhibitor of α/β-hydrolase domain-containing 6 (ABHD6), a serine hydrolase that acts as an alternative hydrolase of the endocannabinoid 2-arachidonoylglycerol (2-AG). | |||
| M8624 | HPB | HPB | Others |
| HPB is a cell-permeable, non-cytotoxic N-hydroxybenzamide derivative that acts as a HDAC6-selective deacetylase inhibitor (IC50 = 31/376/677/842/1133 nM against HDAC6/8/10/1/7, >2 μM against HDAC2/3/4/11/9/5). | |||
| M8629 | Cbz-B3A | Cbz-B3A | Others |
| Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that inhibits the phosphorylation of eIF4E binding protein 1 (4EBP1) and blocks 68% of translation. | |||
| M8639 | STK16-IN-1 | STK16-IN-1 | Others |
| STK16-IN-1 is a cell-permeable pyrrolonaphthyridinone compound that acts as an ATP-competitive inhibitor against NAK (Numb Associated Kinase) family serine/threonine kinase STK16 (IC50/substrate = 0. | |||
| M8770 | Didox | Didox | Others |
| N,3,4-Trihydroxybenzamide | |||
| Didox is a ribonucleotide reductase (RNR) inhibitor that inhibits proliferation of and decreased secretion of cytokines IL-6, IFN-g, TNF-a, IL-2, IL-13, IL-10 and IL-4. | |||
| M8959
|
BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1) | BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1) | PD-1/PD-L1 |
| BMS-1 (PD-1/PD-L1 inhibitor 1, PD1-PDL1-IN1)是一种PD-1/PD-L1相互作用的小分子化合物抑制剂，IC50为6 nM，也是一种免疫调节剂。 | |||
