找到约 30 条 “Cannabinoid” 相关结果 （用时 0.15 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M2012
|
AM1241 | AM1241 | Cannabinoid |
| AM1241是一种选择性的cannabinoid CB2 receptor激动剂，Ki为3.4 nM，比作用于CB1受体选择性高82倍。 | |||
| M2051
|
CP 945598 hydrochloride | CP 945598 hydrochloride | Cannabinoid |
| Otenabant HCl; Otenabant hydrochloride | |||
| Otenabant (CP-945598) HCl是一种有效的，选择性cannabinoid receptor CB1拮抗剂，Ki为0.7 nM，比作用于人类CB2受体选择性高10，000倍。 | |||
| M2461
|
BML-190 | BML-190 | Cannabinoid |
| IMMA | |||
| BML-190是一种选择性的cannabinoid CB2 receptor逆向激动剂，Ki为435 nM，比作用于CB1受体选择性高50倍。 | |||
| M2552
|
Otenabant | 奥替那班 | Cannabinoid |
| CP-945598; CP945598 | |||
| Otenabant (CP-945598) 是一种有效的，选择性cannabinoid receptor CB1拮抗剂，Ki为0.7 nM，比作用于人类CB2受体选择性高10，000倍。 | |||
| M3266
|
WIN 55212-2 mesylate | WIN 55212-2 mesylate | Cannabinoid |
| (R)-(+)-WIN 55212 | |||
| win55212 -2是一种有效的 cannabinoid receptor 激动剂，在人克隆CB1和CB2受体上的Ki分别为62.3和3.3 nM。 | |||
| M3282
|
GW842166X | GW842166X | Cannabinoid |
| GW842166X是一种有效的，高选择性cannabinoid receptor CB2受体激动剂，EC50为63 nM，对CB1受体没有显著的活性。 | |||
| M6626 | CP 55,940 | CP 55,940 | Others |
| CP 55,940 is a potent, non-selective cannabinoid receptor agonist. | |||
M7325
|
Rimonabant Hydrochloride | 盐酸利莫那班 | Cannabinoid |
| SR 141716A; SR 151716A | |||
| Rimonabant hydrochloride 是一种大麻素受体 (cannabinoid receptor) 拮抗剂，高亲和力地选择性结合到中枢大麻素受体 (CB1)，Ki 为 2 nM。 | |||
| M7418 | Tocrifluor T1117 | Tocrifluor T1117 | Others |
| Tocrifluor T1117 is a fluorescent cannabinoid ligand; fluorescent form of AM 251. | |||
| M7821 | GW833972A | GW833972A | Others |
| GW833972A is a CB2 cannabinoid receptor agonist with 1000-fold selectivity relative to CB1. | |||
| M7970 | NIDA-41020 | NIDA-41020 | Others |
| NIDA-41020 is a CB1 cannabinoid receptor antagonist. | |||
| M8377 | UCM710 | UCM710 | Others |
| UCM710 is a dual inhibitor of fatty acid amide hydrolase (FAAH) and α/β hydrolase domain 6 (ABHD6) the enzymes that hydrolyze endocannabinoids. | |||
| M8414
|
MJN110 | MJN110 | MAGL |
| MJN110 is a potent selective inhibitor of MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) with >10,000 selectivity over FAAH. | |||
| M8596 | WWL70 | WWL70 | Others |
| WWL70 is a selective inhibitor of α/β-hydrolase domain-containing 6 (ABHD6), a serine hydrolase that acts as an alternative hydrolase of the endocannabinoid 2-arachidonoylglycerol (2-AG). | |||
| M8725
|
SR144528 | SR144528 | Others |
| SR144528 is a potent and highly selective cannabinoid CB2 receptor inverse agonist. | |||
| M8735 | GAT211 | GAT211 | Others |
| GAT211 is a positive allosteric modulator (PAM) of cannabinoid CB1 receptor signaling. | |||
| M8749 | GAT228 | GAT228 | Others |
| GAT228 is the R-(+)-enantiomer of GAT211, a positive allosteric modulator (PAM) of cannabinoid CB1 receptor signaling that was found to amplify the therapeutic effect of endocannabinoids without the negative side effects of psychoactivity or tolerance. | |||
| M8985
|
LY2828360 | LY2828360 | Cannabinoid |
| LY2828360是一种新型强效，选择性和有效的CB2 cannabinoid激动剂。 | |||
| M10652
|
Voacamine | 老刺木胺 | Cannabinoid |
| Voacamine is an indole alkaloid, exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells. | |||
| M10891 | Taranabant | Taranabant | Others |
| MK-0364 | |||
| Taranabant 是一种有效的选择性的 cannabinoid 1 (CB1) 受体反向激动剂，抑制结合和多种激动剂的功能活性，作用于人 CB1R，Ki 为 0.13 nM。 | |||
| M18745
|
Cannabichromene | 大麻色原烯 | Cannabinoid |
| (±)-Cannabichromene | |||
| Cannabichromene is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 (TRPA1), it selectively reduces inflammation-induced hypermotility in vivo in a manner that is not dependent on cannabinoid receptors or TRPA1. | |||
| M45341 | Ajulemic acid | Ajulemic acid | Cannabinoid |
| Lenabasum; IP 751 | |||
| Ajulemic acid是一种合成的，可口服的 Δ9-四氢大麻酚代谢类似物，同时也是大麻素受体 (cannabinoid receptor) 激动剂，对 hCB1 和 hCB2 的 Ki 值分别为 5.7 nM，56.1 nM，EC50 值分别为 11.6 nM，13.4 nM。 | |||
| M25437
|
Noladin ether | Noladin ether | Cannabinoid |
| Noladin ether 是一种有效的，选择性的 cannabinoid 1 (CB1) 受体激动剂，Ki 值为 21.2 nM。 | |||
| M28030 | AM-6538 | AM-6538 | Cannabinoid |
| AM6538 是一种长效、高亲和力、伪不可逆的 cannabinoid (CB) 拮抗剂。AM6538 是利莫那班的结构类似物。AM6538可有效评价大麻素完全和部分激动剂的表观疗效。AM6538 可能在未来需要暂时减少大麻素受体可用性的研究中有用。 | |||
| M30122 | Ibipinabant | Ibipinabant | Cannabinoid |
| SLV319; BMS-646256 | |||
| Ibipinabant (SLV319) 是一种有效，选择性和具有口服活性的大麻素 CB1 受体 (cannabinoid CB1 receptor) 的拮抗剂，Ki 值为 7.8 nM。Ibipinabant 对 CB1 的选择性比对 CB2 (Ki=7943 nM) 的选择性高 1000 倍以上。Ibipinabant 可用于肥胖和糖尿病的研究。 | |||
| M30173 | NESS 0327 | NESS 0327 | Cannabinoid |
| NESS 0327 是一种大麻素 cannabinoid 拮抗剂，对大麻素 CB1 受体具有高选择性。 | |||
| M54860 | Vicasinabin | Vicasinabin | Cannabinoid |
| RG7774 | |||
| Vicasinabin (RG7774) 是一种 cannabinoid receptor 2 (CB2) 的有效激动剂。 | |||
| M55410
|
N-Arachidonoyl-L-Serine | N-Arachidonoyl-L-Serine | Others |
| ARA-S | |||
| N-Arachidonoyl-L-Serine is an endocannabinoid-like brain constituent with similar biological profile like abnormal cannabidiol. N-Arachidonoyl-L-Serine binds weakly to CB1 and CB2 receptors and TRPV1. N-Arachidonoyl-L-Serine produces endothelium-dependent vasodilation. Increases phosphorylation of Akt and mitogen-activated protein. | |||
| M56149
|
AEF0117 | AEF0117 | Cannabinoid |
| AEF0117 是大麻素受体 1 (cannabinoid receptor 1) 信号传导特异性抑制剂 (CB1-SSi)。 | |||
| M56153 | UCM707 | UCM707 | Cannabinoid |
| UCM707 是一种有效和选择性的内源性大麻素摄取 (endocannabinoid uptake) 抑制剂，可增强 Anandamide 的运动功能减退和镇痛作用。 | |||
