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Src-bcr-Abl 抑制剂/激活剂/调节剂 Src-bcr-Abl

目录号 产品名称 产品简介
M2331 PP2 (AGL 1879) PP2是一种Src家族激酶抑制剂,有效抑制Lck/Fyn,IC50为4 nM/5 nM,作用于EGFR效果低100倍左右,抑制ZAP-70, JAK2和PKA活性。
M1712 FTY720 hydrochloride Fingolimod (FTY720) HCl是一种1-磷酸-神经鞘氨醇S1P受体拮抗剂,IC50为0.33 nM。
M1701 Dasatinib Dasatinib是一种Src/Abl抑制剂,对生型Abl和Src激酶均有抑制作用,IC50分别为0.6 nM和0.8 nM。
M1648 AP24534 Ponatinib (AP24534)是一种新型有效的作用于Abl, PDGFRα, VEGFR2, FGFR1和Src的多靶点抑制剂, IC50分别为0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM和5.4 nM。
M1799 Imatinib Mesylate Imatinib Mesylate (STI571)是Imatinib的甲磺酸盐,具有较好的口服生物利用度,是一种多靶点的抑制剂,同时作用于v-Abl, c-Kit和PDGFR,IC50分别为0.6 μM, 0.1 μM 和0.1 μM。
M20833 Vodobatinib (K0706) Vodobatinib (K0706, SCO-088, SUN K706, SUN-K0706) is a novel BCR-ABL1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants with IC50s of 167 nM, 154 nM,165 nM and 1967 nM for BCR-ABL1L248R, BCR-ABL1Y253H , BCR-ABL1E255V and BCR-ABL1T315I, respectively.
M20763 DGY-06-116 DGY-06-116 is an irreversible covalent and selective inhibitor of Src with IC50 of 2.6 nM.
M20707 RK 24466 RK-24466 (KIN 001-51) is a potent and selective inhibitor of Lck that inhibits two constructs of the human lck kinase, lck (64-509) and lckcd with IC50 of < 0.001 μM and 0.002 μM, respectively.
M20634 UM-164 UM-164 is a highly potent, dual c-Src/p38inhibitor of c-Src with a binding constant Kd of 2.7 nM for c-Src and inhibits both p38α and p38β.
M20633 TP0427736 HCl TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM.
M20580 HG-14-10-04 HG-14-10-04 is an inhibitor of ALK .
M20506 7-Hydroxy-4-chromone 7-Hydroxychromone is a Src kinase inhibitor with an IC50 of <300 μM.
M20466 Nilotinib hydrochloride Nilotinib hydrochloride is the hydrochloride salt form of nilotinib, an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
M20137 WAY-329689 WAY-329689 has ABL kinase inhibiting activities.
M20136 WAY-329686 WAY-329686 has ABL kinase inhibiting activities.
M20135 WAY-329685 WAY-329685 has ABL kinase inhibiting activities.
M20128 WAY-329424 WAY-329424 has ABL kinase inhibiting activities.
M20127 WAY-329423 WAY-329423 has ABL kinase inhibiting activities.
M20126 WAY-329412 WAY-329412 has ABL kinase inhibiting activities.
M20125 WAY-329410 WAY-329410 has ABL kinase inhibiting activities.
M20124 WAY-329356 WAY-329356 has ABL kinase inhibiting activities.
M20123 WAY-329341 WAY-329341 has ABL kinase inhibiting activities.
M20122 WAY-329340 WAY-329340 has ABL kinase inhibiting activities.
M20121 WAY-328158 WAY-328158 is a Inhibitor for BCR-ABL Kinase.
M20022 GI-560708 GI-560708 is a inhibitor of BCR-ABL tyrosine kinase.









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