Src-bcr-Abl 抑制剂/激活剂/调节剂 Src-bcr-Abl

目录号	产品名称	产品简介
M2331	PP2 (AGL 1879)	PP2是一种Src家族激酶抑制剂，有效抑制Lck/Fyn，IC50为4 nM/5 nM，作用于EGFR效果低100倍左右，抑制ZAP-70， JAK2和PKA活性。
M1712	FTY720 hydrochloride	Fingolimod (FTY720) HCl是一种1-磷酸-神经鞘氨醇S1P受体拮抗剂，IC50为0.33 nM。
M1701	Dasatinib	Dasatinib是一种Src/Abl抑制剂，对生型Abl和Src激酶均有抑制作用，IC50分别为0.6 nM和0.8 nM。
M1648	AP24534	Ponatinib (AP24534)是一种新型有效的作用于Abl， PDGFRα， VEGFR2， FGFR1和Src的多靶点抑制剂， IC50分别为0.37 nM， 1.1 nM， 1.5 nM， 2.2 nM和5.4 nM。
M1799	Imatinib Mesylate	Imatinib Mesylate (STI571)是Imatinib的甲磺酸盐，具有较好的口服生物利用度，是一种多靶点的抑制剂，同时作用于v-Abl， c-Kit和PDGFR，IC50分别为0.6 μM， 0.1 μM 和0.1 μM。
M20833	Vodobatinib (K0706)	Vodobatinib (K0706, SCO-088, SUN K706, SUN-K0706) is a novel BCR-ABL1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants with IC50s of 167 nM, 154 nM,165 nM and 1967 nM for BCR-ABL1^L248R, BCR-ABL1^Y253H , BCR-ABL1^E255V and BCR-ABL1^T315I, respectively.
M20763	DGY-06-116	DGY-06-116 is an irreversible covalent and selective inhibitor of Src with IC50 of 2.6 nM.
M20707	RK 24466	RK-24466 (KIN 001-51) is a potent and selective inhibitor of Lck that inhibits two constructs of the human lck kinase, lck (64-509) and lckcd with IC50 of < 0.001 μM and 0.002 μM, respectively.
M20634	UM-164	UM-164 is a highly potent, dual c-Src/p38inhibitor of c-Src with a binding constant Kd of 2.7 nM for c-Src and inhibits both p38α and p38β.
M20633	TP0427736 HCl	TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM.
M20580	HG-14-10-04	HG-14-10-04 is an inhibitor of ALK .
M20506	7-Hydroxy-4-chromone	7-Hydroxychromone is a Src kinase inhibitor with an IC50 of <300 μM.
M20466	Nilotinib hydrochloride	Nilotinib hydrochloride is the hydrochloride salt form of nilotinib, an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
M20137	WAY-329689	WAY-329689 has ABL kinase inhibiting activities.
M20136	WAY-329686	WAY-329686 has ABL kinase inhibiting activities.
M20135	WAY-329685	WAY-329685 has ABL kinase inhibiting activities.
M20128	WAY-329424	WAY-329424 has ABL kinase inhibiting activities.
M20127	WAY-329423	WAY-329423 has ABL kinase inhibiting activities.
M20126	WAY-329412	WAY-329412 has ABL kinase inhibiting activities.
M20125	WAY-329410	WAY-329410 has ABL kinase inhibiting activities.
M20124	WAY-329356	WAY-329356 has ABL kinase inhibiting activities.
M20123	WAY-329341	WAY-329341 has ABL kinase inhibiting activities.
M20122	WAY-329340	WAY-329340 has ABL kinase inhibiting activities.
M20121	WAY-328158	WAY-328158 is a Inhibitor for BCR-ABL Kinase.
M20022	GI-560708	GI-560708 is a inhibitor of BCR-ABL tyrosine kinase.

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Src-bcr-Abl 抑制剂/激活剂/调节剂 Src-bcr-Abl

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