找到约 58 条 “TH34” 相关结果 (用时 0.055 秒)
目录号 | 产品名称 | 中文名称 | 靶点 |
---|---|---|---|
M3192
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TRAM-34 | TRAM-34 | Potassium Channel |
Triarylmethane-34 | |||
TRAM-34是一种有效的,选择性的Ca2+-activated K+ channel (IKCa1, KCa3.1)(钙激活的K+通道)抑制剂,Kd为20 nM,比作用于其他离子通道选择性高200到1500倍,且不抑制细胞色素P450。 | |||
M3491
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OSI-420 | OSI-420 | EGFR/HER2 |
Desmethyl Erlotinib; CP-473420 | |||
OSI-420是Erlotinib的活性代谢产物(是一种EGFR抑制剂,IC50为2 nM)。 | |||
M9919
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TH1834 | TH1834 | Histone Acetyltransferase |
TH-1834 | |||
TH1834 is a specific Tip60 (KAT5) histone acetyltransferase (HAT) inhibitor. | |||
M10319 | Parathyroid Hormone (1-34), bovine Acetate | Parathyroid Hormone (1-34), bovine Acetate | Others |
Parathyroid Hormone (1-34), bovine Acetate是一种有效的甲状旁腺激素 (PTH) 受体的激动剂。 | |||
M10330
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Teriparatide acetate | 特立帕肽醋酸盐 | Others |
hPTH (1-34) acetate; Parathar acetate | |||
Teriparatide acetate(特立帕肽醋酸盐)是一种 PHT 的激动剂,含有34个氨基酸,能维持钙稳态、增加皮质和小梁厚度以及刺激骨形成,其在 HEK293 细胞中的 IC50 值为 2 nM。可用于骨质疏松症(OP)和骨关节炎(OA)的相关研究。 | |||
M11571 | ChemBridge-4015344 | ChemBridge化合物-4015344 | Screening Compounds and Building Blocks |
4-methyl-3-(2-thienyl)-1H-pyrazol-5-amine hydrochloride (4015344) | |||
ChemBridge特有类药化合物/先导化合物-4015344,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M11598 | ChemBridge-5104346 | ChemBridge化合物-5104346 | Screening Compounds and Building Blocks |
2,6,7-trihydroxy-9-phenyl-3H-xanthen-3-one (5104346) | |||
ChemBridge特有类药化合物/先导化合物-5104346,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M11627 | ChemBridge-5113462 | ChemBridge化合物-5113462 | Screening Compounds and Building Blocks |
4-hydroxy-3-methoxybenzaldehyde 5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-ylhydrazone (5113462) | |||
ChemBridge特有类药化合物/先导化合物-5113462,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M11673 | ChemBridge-5134246 | ChemBridge化合物-5134246 | Screening Compounds and Building Blocks |
1-hydroxyanthra-9,10-quinone (5134246) | |||
ChemBridge特有类药化合物/先导化合物-5134246,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M11707 | ChemBridge-5143134 | ChemBridge化合物-5143134 | Screening Compounds and Building Blocks |
3-phenyl-N-[2,2,2-trichloro-1-({[(4-chlorophenyl)amino]carbonothioyl}amino)ethyl]acrylamide (5143134) | |||
ChemBridge特有类药化合物/先导化合物-5143134,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M11803 | ChemBridge-5202034 | ChemBridge化合物-5202034 | Screening Compounds and Building Blocks |
2-(2,4-dimethylphenoxy)-N'-(4-hydroxy-3-iodobenzylidene)acetohydrazide (5202034) | |||
ChemBridge特有类药化合物/先导化合物-5202034,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M11815 | ChemBridge-5210834 | ChemBridge化合物-5210834 | Screening Compounds and Building Blocks |
N-(3-methylphenyl)-3-(1-piperidinylsulfonyl)benzamide (5210834) | |||
ChemBridge特有类药化合物/先导化合物-5210834,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M11879 | ChemBridge-5234221 | ChemBridge化合物-5234221 | Screening Compounds and Building Blocks |
2-hexyl-1-cyclopentanone thiosemicarbazone (5234221) | |||
ChemBridge特有类药化合物/先导化合物-5234221,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M11880 | ChemBridge-5234224 | ChemBridge化合物-5234224 | Screening Compounds and Building Blocks |
2-butyl-1-cyclohexanone thiosemicarbazone (5234224) | |||
ChemBridge特有类药化合物/先导化合物-5234224,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M11881 | ChemBridge-5234225 | ChemBridge化合物-5234225 | Screening Compounds and Building Blocks |
2-(2-butoxyethyl)-1-cyclopentanone thiosemicarbazone (5234225) | |||
ChemBridge特有类药化合物/先导化合物-5234225,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M11882 | ChemBridge-5234242 | ChemBridge化合物-5234242 | Screening Compounds and Building Blocks |
2,4-dibromo-6-{[(2-chlorobenzoyl)amino]methyl}phenyl 2-nitrobenzoate (5234242) | |||
ChemBridge特有类药化合物/先导化合物-5234242,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M11883 | ChemBridge-5234250 | ChemBridge化合物-5234250 | Screening Compounds and Building Blocks |
2,4-dibromo-6-{[(2-chlorobenzoyl)amino]methyl}phenyl 4-fluorobenzoate (5234250) | |||
ChemBridge特有类药化合物/先导化合物-5234250,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M11884 | ChemBridge-5234251 | ChemBridge化合物-5234251 | Screening Compounds and Building Blocks |
2,4-dibromo-6-{[(2-chlorobenzoyl)amino]methyl}phenyl 2-methylbenzoate (5234251) | |||
ChemBridge特有类药化合物/先导化合物-5234251,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M11885 | ChemBridge-5234291 | ChemBridge化合物-5234291 | Screening Compounds and Building Blocks |
2-{[(2-chlorobenzoyl)amino]methyl}-4,6-dimethylphenyl 2,4-dichlorobenzoate (5234291) | |||
ChemBridge特有类药化合物/先导化合物-5234291,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M11886 | ChemBridge-5234974 | ChemBridge化合物-5234974 | Screening Compounds and Building Blocks |
N-hydroxy-3-(4-methylphenyl)-1-adamantanecarboxamide (5234974) | |||
ChemBridge特有类药化合物/先导化合物-5234974,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M12008 | ChemBridge-5341866 | ChemBridge化合物-5341866 | Screening Compounds and Building Blocks |
4-(4-methoxyphenyl)-5-methyl-1,3-thiazol-2-amine (5341866) | |||
ChemBridge特有类药化合物/先导化合物-5341866,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M12010 | ChemBridge-5342191 | ChemBridge化合物-5342191 | Screening Compounds and Building Blocks |
N-[4-chloro-3-(trifluoromethyl)phenyl]-7-nitro-2,1,3-benzoxadiazol-4-amine (5342191) | |||
ChemBridge特有类药化合物/先导化合物-5342191,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M12011 | ChemBridge-5344221 | ChemBridge化合物-5344221 | Screening Compounds and Building Blocks |
4-[(2,2'-bithien-5-ylmethylene)amino]phenol (5344221) | |||
ChemBridge特有类药化合物/先导化合物-5344221,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M12012 | ChemBridge-5344362 | ChemBridge化合物-5344362 | Screening Compounds and Building Blocks |
N''-{4-[(4-bromo-2,3,5,6-tetramethylbenzyl)oxy]-3-methoxybenzylidene}carbonohydrazonic diamide hydrochloride (5344362) | |||
ChemBridge特有类药化合物/先导化合物-5344362,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M12017 | ChemBridge-5349825 | ChemBridge化合物-5349825 | Screening Compounds and Building Blocks |
4-chloro-5-(ethylthio)-2-phenyl-3(2H)-pyridazinone (5349825) | |||
ChemBridge特有类药化合物/先导化合物-5349825,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M12034 | ChemBridge-5360134 | ChemBridge化合物-5360134 | Screening Compounds and Building Blocks |
N-(2-bromo-4-methylphenyl)-2-(4-ethylphenoxy)acetamide (5360134) | |||
ChemBridge特有类药化合物/先导化合物-5360134,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M12038 | ChemBridge-5363403 | ChemBridge化合物-5363403 | Screening Compounds and Building Blocks |
5-(4-bromobenzylidene)-1,3-thiazolidine-2,4-dione (5363403) | |||
ChemBridge特有类药化合物/先导化合物-5363403,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M12107 | ChemBridge-5493343 | ChemBridge化合物-5493343 | Screening Compounds and Building Blocks |
2-(4,5-dihydro-1,3-thiazol-2-ylthio)-1-(3,4-dihydroxyphenyl)ethanone hydrobromide (5493343) | |||
ChemBridge特有类药化合物/先导化合物-5493343,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M12123 | ChemBridge-5534420 | ChemBridge化合物-5534420 | Screening Compounds and Building Blocks |
4-[(2,4-dinitrophenyl)diazenyl]-1-naphthol (5534420) | |||
ChemBridge特有类药化合物/先导化合物-5534420,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M12179 | ChemBridge-5604934 | ChemBridge化合物-5604934 | Screening Compounds and Building Blocks |
2-[3-methyl-5-(4-morpholinyl)benzyl]-1H-isoindole-1,3(2H)-dione (5604934) | |||
ChemBridge特有类药化合物/先导化合物-5604934,由AbMole(奥默生物)独家提供。具体售价货期请咨询AbMole(奥默生物)。运费额外计算。 | |||
M2296
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3-Methyladenine (3-MA) | 3-甲基腺嘌呤 | PI3K |
3-MA | |||
3-Methyladenine (3-MA)是一种选择性PI3K抑制剂,作用于Vps34和PI3Kγ,IC50分别为25 μM和60 μM;永久抑制I型PI3K,但对III型PI3K的抑制是短暂的,也抑制自噬体的形成。现配现用 | |||
M2418
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AZD1981 | AZD1981 | GPR/FFAR |
AZD1981是一种有效的,选择性CRTh2 (DP2) receptor拮抗剂,IC50为4 nM,比作用于340种其他酶和受体(包括DP1)选择性高1000多倍。 | |||
M2622
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Desmethyl Erlotinib | 去甲基厄洛替尼;埃罗替尼杂质H;厄洛替尼杂质N | Metabolite/Endogenous Metabolite |
Desmethyl Erlotinib (CP-473420, OSI-774)是OSI-420的游离碱,是Erlotinib(一种EGFR抑制剂,IC50为2 nM)的活性代谢物。 | |||
M6264
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Favipiravir | 法匹拉韦 | DNA/RNA Synthesis |
T-705 | |||
Favipiravir (T-705) 是一种有效的选择性RNA-dependent RNA 聚合酶 (RNA polymerase) 抑制剂,抑制RNA合成(RNA Synthesis)。其活性形式 Favipiravir-ribofuranosyl-5′-triphosphate (RTP) 抑制流感病毒RNA依赖性的RNA聚合酶 (RdRP) 活性,IC50 为 341 nM。 | |||
M7137
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Phosphoramidon disodium salt | Phosphoramidon disodium salt | Neprilysin (NEP) |
Phosphoramidon disodium salt是一种微生物代谢物,同时也是特异性金属蛋白酶嗜热菌蛋白酶 (metalloprotease thermolysin) ,内皮素转换酶 (ECE),中性肽酶 (NEP) 和血管紧张素转换酶 (ACE)的抑制剂,IC50 分别为0.4 μg/mL,3.5 μM、0.034 μM 和 78 μM。此外,Phosphoramidon disodium salt还能阻止淀粉样蛋白 β 肽的降解,并可增加啮齿类动物体内的 Aβ 水平。 | |||
M8803
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Thiolutin | 硫藤黄素 | Others |
Acetopyrrothin | |||
Thiolutin (Acetopyrrothin) 是细菌和酵母 RNA 聚合酶的有效抑制剂。Thiolutin 抑制 JAB1/MPN/Mov34 (JAMM) 金属蛋白酶 Csn5, SHAM-Domain-of-STAM (AMSH) 相关的分子以及特异性去泛素酶 Brcc36。 | |||
M9506
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TH5487 | TH5487 | DNA/RNA Synthesis |
TH-5487 | |||
TH5487是一种选择性的8-oxoguanine鸟嘌呤DNA糖基化酶1(OGG1)抑制剂,可以阻止 OGG1 识别其 DNA 底物,抑制 DNA 修复,IC50为342 nM。 | |||
M10596
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BIBF0775 | BIBF0775 | TGF-β Receptor |
BIBF-0775 | |||
BIBF0775是一种有效的,选择性的 transforming growth factor β Receptor I (TGFβRI,Alk5) 的抑制剂,IC50为34 nM。 | |||
M13447
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Recombinant Human IGF-II (E. coli) | 重组人胰岛素样生长因子-II蛋白(E. coli) | Cytokines and Growth Factors |
Insulin-like Growth Factor-II; Somatamedin A | |||
胰岛素样生长因子II (insulin -like Growth Factor II, IGF-II)是一种7 kDa的单链多肽,与胰岛素具有高度的同源性。蛋白构造:用n端Met表示。IGF-II (Ala25-Glu91),Accession # P01344-1。 | |||
M14784
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Teriparatide | 特立帕肽 | Others |
Human parathyroid hormone-(1-34); hPTH (1-34) | |||
Teriparatide (Human parathyroid hormone-(1-34)) 是 PHT 的激动剂,含有34个氨基酸,能维持钙稳态、增加皮质和小梁厚度以及刺激骨形成,其在 HEK293 细胞中的 IC50 值为 2 nM。可用于骨质疏松症(OP)和骨关节炎(OA)的相关研究。 | |||
M15031
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Recombinant Mouse FGF-9 (E. coli) | 重组小鼠FGF-9 蛋白(E. coli) | Cytokines and Growth Factors |
Fibroblast Growth Factor-9; FGF9 | |||
成纤维细胞生长因子-9 (FGF-9)是一种多效细胞因子,属于肝素结合FGF家族。像家族中的其他成员一样,FGF-9类似于β-三叶结构。蛋白构造:Expressed with an N-terminal Met. FGF-9 [Pro3-Ser208(Ser34Asn)],Accession # P54130。 | |||
M17972 | 1-Methyl-2-[ (4Z,7Z)-4,7-tridecadienyl]-4 (1H)-quinolone | 1-甲基-2-[(4Z,7Z)-4,7-十三碳二烯]-4(1H)-喹诺酮 | Others |
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone,一种喹诺酮类生物碱,是二酰基甘油酰基转移酶抑制剂和血管紧张素 II 受体阻断剂,IC50 值分别为 20.1 μM 和 34.1 μM。 | |||
M20644 | TH34 | TH34 | HDAC |
TH34 is a HDAC inhibitor that shows pronounced selectivity for HDACs 6, 8 and 10 over HDACs 1, 2 and 3. In a NanoBRET assay, TH34 strongly binds HDAC6, 8 and 10 with low-micromolar IC50 concentrations (HDAC6: 4.6 µM, HDAC8: 1.9 µM, HDAC10: 7.7 µM). | |||
M20977 | BAY 2416964 | BAY 2416964 | Aryl hydrocarbon Receptor |
BAY 2416964 (compound 192) is a potent and orally active antagonist of aryl hydrocarbon receptor (AhR) with IC50 of 341 nM. BAY 2416964 has the potential in the treatment of solid tumors. | |||
M21402
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Recombinant Mouse IL-27 (HEK293, C-6His) | 重组小鼠IL-27 蛋白 (HEK293, C-6His) | Cytokines and Growth Factors |
Interleukin-27 subunit alpha; IL-27 subunit alpha | |||
IL-27 is a heterodimeric cytokine which belongs to the IL-6/IL-12 family of long type I cytokines. Recombinant Mouse Interleukin-27 Subunit Alpha and Interleukin-27 Subunit Beta expressed the target gene encoding Tyr19-Pro228&Phe29-Ser234 with a 6His tag at the C-terminus. | |||
M25388
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9-Aminocamptothecin | 9-氨基喜树碱 | Topoisomerase |
9-amino-CPT; 9-amino-20(S)-camptothecin | |||
9-Aminocamptothecin (9-amino-CPT) 是一种拓扑异构酶I的抑制剂,具有抗肿瘤活性。9-氨基喜树碱(处理96小时)对PC-3、PC-3M、DU145和LNCaP细胞抑制作用的IC50值分别为34.1、10、6.5和8.9 nM。 | |||
M25536
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Recombinant Human CXCL13/BCA-1 (E. coli) | 重组人CXCL13/BCA-1蛋白 (E. coli) | Cytokines and Growth Factors |
CXC chemokine BLC; Small-inducible cytokine B13 | |||
CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Recombinant human CXCL13 is a single non-glycosylated polypeptide chain containing 87 amino acids and mature human BCA-1 shares 64 % amino acid sequence similarity with the murine protein and 23–34 % amino acid sequence identity with other known CXC chemokines. Determined by a chemotaxis bioassay using human B cells, the biological activity is in a concentration range of 1.0-10 ng/ml. | |||
M28808 | Dyrk1A-IN-5 | Dyrk1A-IN-5 | DYRK |
Dyrk1A-IN-5 (compound 5j) 是一种强效且选择性的 DYRK1A 抑制剂,其 IC50 值为 6 nM。Dyrk1A-IN-5 剂量依赖性地降低 SF3B1 中 Thr434 的磷酸化,其 IC50 为 0.5 μM。Dyrk1A-IN-5 可抑制 tau 蛋白在 Thr212 位点的磷酸化,其 IC50 为 2.1 μM。Dyrk1A-IN-5 可用于唐氏综合征的研究。 | |||
M29173 | GSK3494245 | GSK3494245 | Parasite |
DDD01305143 | |||
GSK3494245 (DDD01305143) 是一种有效的、具有口服活性的、选择性的可在夹在 β4 和 β5 亚基之间的位点结合寄生虫蛋白酶体 (proteasome) 的糜蛋白酶样活性抑制剂(对于 WT L.donovani蛋白酶体IC50=0.16μM)。GSK3494245 适度抑制人蛋白酶体的糜蛋白酶样活性 (IC50: 26S=13 µM;富集的 THP-1 提取物 IC50=40 µM)。GSK3494245 具有良好的生物安全特性。 | |||
M29245 | TH1834 dihydrochloride | TH1834 dihydrochloride | Histone Acetyltransferase |
TH1834 dihydrochloride 是一种特异性的 Tip60 (KAT5) 组蛋白乙酰转移酶抑制剂。TH1834 dihydrochloride 可诱导乳腺癌细胞凋亡并增加 DNA 损伤。TH1834 dihydrochloride 不影响相关组蛋白乙酰转移酶 MOF 的活性。抗癌活性。 | |||
M30721 | Ralimetinib | Ralimetinib | p38 MAPK |
LY2228820 | |||
Ralimetinib (LY2228820) 是一种有效、选择性、ATP-竞争性的 p38 MAPK α/β 抑制剂,IC50 值分别为 5.3 和 3.2 nM。Ralimetinib (LY2228820) 选择性地抑制 MK2 (Thr334) 磷酸化,但对 p38α MAPK,JNK,ERK1/2,c-Jun,ATF2 或 c-Myc 的磷酸化水平无作用。 | |||
M30755 | ONO-5334 | ONO-5334 | Cathepsin |
ONO-5334 是一种强效、选择性和口服活性的组织蛋白酶 K (cathepsin K) 抑制剂,对人、兔和大鼠组织蛋白酶 K 的作用值分别为 0.10 nM、0.049 nM 和 0.85 nM。ONO-5334 是一种有效的抗 SAR-COV-2 病毒活性的抗病毒化合物,其 EC50 值为 500 nM。ONO-5334 有潜力用于骨质疏松症以及 COVID-19 的相关研究。 | |||
M40857
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Recombinant Human SIGLEC-7 Protein (HEK293, His Tag) | 重组人SIGLEC-7蛋白 (HEK293, His Tag) | Receptor Proteins |
sialic acid binding Ig-like lectin 7; CD328 antigen; p75/AIRM1; QA79 | |||
Recombinant Human Sialic Acid-binding Ig-like Lectin 7 expressed the target gene encoding the Human SIGLEC7 (Q9Y286-1) (Met1-Leu353) was expressed with a polyhistidine tag at the C-terminus. The recombinant Human SIGLEC7 consists of 346 amino acids and predicts a molecular mass of 38.4 kDa. | |||
M41668 | BET-IN-16 | BET-IN-16 | Epigenetic Reader Domain |
BET-IN-16 is a BET inhibitor. BET-IN-16 shows anticancer activity. BET-IN-16 inhibits prostate cancer cell growth, with IC50 values of 0.043 and 0.034 μM against LNCaP and 22Rv1 cells, respectively.。 | |||
M41901 | PSB-1114 triethylamine | PSB-1114 triethylamine | P2 Receptor |
PSB-1114 triethylamine 是一种有效、酶稳定、亚型选择性 P2Y2 受体激动剂,具有 EC50=134 nM。 | |||
M50369 | pTH (3-34) (bovine) | pTH (3-34) (bovine) | Thyroid Hormone Receptor |
pTH (3-34) (bovine) 是一种人甲状旁腺激素(pTH)片段。 | |||
M50370 | pTH (13-34) (human) | pTH (13-34) (human) | Thyroid Hormone Receptor |
pTH (13-34) (human) 是一种人甲状旁腺激素(pTH)片段。 | |||
M50376
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Parathyroid hormone (1-34) (rat) | Parathyroid hormone (1-34) (rat) | Thyroid Hormone Receptor |
Parathyroid hormone (1-34) (rat) 是甲状旁腺激素。 |