成纤维细胞生长因子-9 (FGF-9)是一种多效细胞因子,属于肝素结合FGF家族。像家族中的其他成员一样,FGF-9类似于β-三叶结构。蛋白构造:Expressed with an N-terminal Met. FGF-9 [Pro3-Ser208(Ser34Asn)],Accession # P54130。
别名:Fibroblast Growth Factor-9; FGF9
种属:Mouse
表达系统:E. coli
纯度:SDS-PAGE分析,> 95%,高效液相色谱分析> 95%
内毒素:凝胶凝血法测定蛋白质< 0.2 EU/μg
表观分子量:~23.4 kDa,还原条件下在SDS-PAGE上
存储及稳定性:在接收后,该产品在低于-70°C的环境下保持稳定长达6个月。重组后,产品应在4°C下稳定1周或在-20°C下稳定3个月。为了长期保存,建议添加载体蛋白(如0.1% BSA)。避免反复的冻融循环。
生物活性:ED50 < 5.0 ng/ml,采用3T3细胞增殖法测定,对应的比活性为> 2.0 × 105单位/mg。FGF-9发生可逆二聚,这是其亚家族成员FGF-16和FGF-20的共同特征。同源二聚化过程中涉及的突变也影响肝素的亲和力、与FGF受体的结合以及生物活性。在体内,FGF-9在肢体芽、发育中的骨骼和胚胎发生后期的肠道中表达。FGF-9对心脏、肺、肾、盲肠和睾丸的发育至关重要;FGF-9水平的降低导致早分化。FGF-9还与骨形态发生蛋白7 (BMP-7)一起促进肾单位祖细胞的存活。
溶解性(25°C) | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O up to 100 μg/ml. |
储存条件 |
粉末型式 -20°C 3年;4°C 2年 溶于溶剂 -80°C 6个月;-20°C 1个月 |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
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