找到约 28 条 “TAI-1” 相关结果 （用时 0.114 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M5293
|
Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO) | 蛋白酶抑制剂Cocktail（不含EDTA，100X DMSO储液） | Inhibitor Cocktails |
| AbMole蛋白酶抑制剂Cocktail（不含EDTA，100X DMSO储液）是一种低毒，全面的蛋白保护试剂，最大限度地保护蛋白免受蛋白酶降解，提高蛋白得率。本品可用于蛋白免疫印迹 (WB)、免疫共沉淀 (Co-IP)、pull-down、免疫沉淀 (IP)、免疫组织化学 (IHC)、免疫荧光 (IF)、酶学研究等多种与蛋白相关的实验。 | |||
M13406
|
Deacetylase Inhibitor Cocktail (100X) | 去乙酰化酶抑制剂Cocktail（100X） | Inhibitor Cocktails |
| AbMole去乙酰化酶抑制剂Cocktail（100X）是一种用于维持组蛋白和其它非组蛋白乙酰化状态的去乙酰化酶抑制剂混合物。AbMole去乙酰化酶抑制剂Cocktail（100X）以 1 mL 小管的形式提供。每个小管含有 1 mL 70% DMSO及以下成分：Trichostatin A (40 μM)，EX-527 (1 mM)，Nicotinamide (400 mM) 和 Sodium Butyrate (200 mM)。 | |||
| M20601
|
TAI-1 | TAI-1 | Microtubule |
| TAI-1 是一种首创的（first-in-class），强效的，特异性的，具有口服活性的 Hec1 抑制剂，能破坏 Hec1-Nek2 蛋白的相互作用。 | |||
| M2830
|
Mdivi-1 | Mdivi-1 | Dynamin |
| Mitochondrial division inhibitor 1 | |||
| Mdivi-1（Mitochondrial division inhibitor 1）是一种动力蛋白相关蛋白1 (Drp1)的GTP酶抑制剂，可调节线粒体动力蛋白的表达，IC50为10 μM。同时能抑制NF-κB信号通路和NLRP3炎症小体的激活。此外，mdivi-1还可通过浓度依赖性的方式，降低快速激活延迟整流K⁺电流(I(Kr))的尾电流(I(tail))的振幅，其IC₅₀值为11.6 μM。Mdivi-1 是一种有效的线粒体分裂/线粒体自噬 (mitophagy) 抑制剂。 | |||
| M8467 | OF-1 | OF-1 | Others |
| OF-1 is a chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) family of scaffolding proteins (BRPF1, BRPF2, BRPF3) that assemble histone acetyltransferase (HAT) complexes of the MYST family members MOZ and MORF. | |||
| M18083 | Matairesinol 4'-O-β-gentiobioside | 罗汉松树脂酚-4'-O-β-龙胆二糖苷 | Others |
| Matairesinol 4′-O-β-D-glucopyranoside 对 HeLa 细胞具有细胞毒活性，IC50 为 47.1 μM。 | |||
| M18217
|
Matairesinol monoglucoside | Matairesinol monoglucoside | Others |
| Matairesinol monoglucoside 是一种木脂素化合物，对 IFN-γ/STAT1 和 IL-6/STAT3 信号通路具有较低的抑制活性，抑制率分别为 5.8% 和 7.0%。 | |||
| M21203
|
Recombinant Human/Mouse/Rat Irisin (HEK293, C-6His) | 重组人/小鼠/大鼠Irisin蛋白 (HEK293, C-6His) | Cytokines and Growth Factors |
| Fibronectin type III domain-containing protein 5 | |||
| Fibronectin type III domain-containing protein 5 is the precursor of irisin. Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts. | |||
| M21204
|
Recombinant Human/Mouse/Rat Irisin (HEK293, C-Fc) | 重组人/小鼠/大鼠Irisin蛋白 (HEK293, C-Fc) | Cytokines and Growth Factors |
| Fibronectin type III domain-containing protein 5 | |||
| Fibronectin type III domain-containing protein 5 is the precursor of irisin. Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts. | |||
| M21205
|
Recombinant Human/Mouse/Rat Irisin (HEK293, N-6His) | 重组人/小鼠/大鼠Irisin 蛋白(HEK293, N-6His) | Cytokines and Growth Factors |
| Fibronectin type III domain-containing protein 5 | |||
| Fibronectin type III domain-containing protein 5 is the precursor of irisin. Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts. | |||
| M21331
|
Recombinant Human CDH1 (HEK293, C-6His) | 重组人CDH1 蛋白 (HEK293, C-6His) | Cytokines and Growth Factors |
| Cadherin-1; CDH1;CAM 120/80;E-cadherin; CD324 | |||
| Recombinant human Cadherin-1/E-Cadherin/CDH1 is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. Accession: P12830. | |||
| M25383
|
Recombinant Human KEAP1 Protein (Baculovirus-Insect) | 重组人KEAP1蛋白 (Baculovirus-Insect) | Cytokines and Growth Factors |
| Kelch-like ECH-associated protein 1; INRF2 | |||
| Kelch-like ECH-associated protein 1 (KEAP1) is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB (POZ) domain, and six Kelch repeats. KEAP1 is a key regulator of the NRF2 transcription factor, which transactivates the antioxidant response element (ARE) and upregulates numerous proteins involved in antioxidant defense. | |||
| M25384
|
Recombinant Human KEAP1 Protein (Baculovirus-Insect, His & GST Tag) | 重组人KEAP1蛋白 (Baculovirus-Insect, His & GST Tag) | Cytokines and Growth Factors |
| Kelch-like ECH-associated protein 1; INRF2 | |||
| Kelch-like ECH-associated protein 1 (KEAP1) is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB (POZ) domain, and six Kelch repeats. KEAP1 is a key regulator of the NRF2 transcription factor, which transactivates the antioxidant response element (ARE) and upregulates numerous proteins involved in antioxidant defense. | |||
| M25536
|
Recombinant Human CXCL13/BCA-1 (E. coli) | 重组人CXCL13/BCA-1蛋白 (E. coli) | Cytokines and Growth Factors |
| CXC chemokine BLC; Small-inducible cytokine B13 | |||
| CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Recombinant human CXCL13 is a single non-glycosylated polypeptide chain containing 87 amino acids and mature human BCA-1 shares 64 % amino acid sequence similarity with the murine protein and 23–34 % amino acid sequence identity with other known CXC chemokines. Determined by a chemotaxis bioassay using human B cells, the biological activity is in a concentration range of 1.0-10 ng/ml. | |||
| M29887 | BPDBA | BPDBA | GABA Receptor |
| BPDBA 是一种选择性和非竞争性 betaine/GABA 转运体 (BGT-1) 抑制剂，对人 BGT-1 和小鼠 GAT2 的 IC50 分别为 20 μM 和 35 μM。 | |||
| M30975 | TLX agonist 1 | TLX agonist 1 | Others |
| TLX agonist 1 (ccrp2) 是一种孤核受体 tailless (TLX, NR2E1) 调节剂 (EC50=1 μM; Kd= 650 nM)。TLX agonist 1 增强 TLX 转录抑制活性。 | |||
| M40232 | Demethylcarolignan E | Demethylcarolignan E | Others |
| Demethylcarolignan E 是一种苯丙素酯，可以从木槿花 (Hibiscus taiwanensi) 的茎中分离出来。Demethylcarolignan E 对人类癌细胞系 A549 和 MCF-7 具有细胞毒性 (IC50: <10 μg/mL)。 | |||
| M42177 | SCS | SCS | GABA Receptor |
| SCS (Salicylidene salicylhydraide) 是一种有效的、变构的、选择性的 β1-containing GABAA receptors 的抑制剂，通过 VIPR 测量，对 α2β1γ1θ 的 IC50 为 32 nM。 | |||
| M43969
|
Recombinant Mouse MMP-12 (HEK293, C-6His) | 重组小鼠MMP-12 (HEK293, C-6His) | Enzymes & Regulators |
| Matrix metalloproteinase-12 | |||
| Matrix metalloproteinase-12 (MMP12) contains 4 hemopexin repeats and belongs to the peptidase M10A family. MMP12 may be involved in tissue injury and remodeling and have significant elastolytic activity. | |||
| M43971
|
Recombinant Human MMP12 Protein (E. coli) | 重组人MMP12 蛋白 (E. coli) | Enzymes & Regulators |
| Matrix metalloproteinase-12 | |||
| Matrix metalloproteinase-12 (MMP12) is a macrophage-secreted elastase that is highly induced in the liver and lung in response to S. mansoni eggs and contains four hemopexin-like domains. MMP12 is a proteolytic enzyme responsible for the cleavage of plasminogen to angiotensin, which has an angiostatic effect. | |||
| M54749
|
Recombinant Rat IL-23 Protein (HEK293, C-His) | 重组大鼠IL-23 蛋白 (HEK293, C-His) | Cytokines and Growth Factors |
| Interleukin-23; IL-23A; IL-23 alpha & IL-12 beta | |||
| IL-23 (IL-23 alpha & IL-12 beta Heterodimer) Protein is a recombinant protein dimer complex containing rat-derived IL-23 alpha & IL-12 beta Heterodimer protein, expressed by HEK293. | |||
| M54826 | LUF5519 | LUF5519 | Adenosine Receptor |
| LUF-5519 | |||
| LUF5519 is a ribose-containing adenosine A1 receptor agonist. | |||
| M55236
|
Recombinant Mouse LTBR Protein (HEK293, C-Fc) | 重组小鼠LTBR 蛋白 (HEK293, C-Fc) | Cytokines and Growth Factors |
| Lymphotoxin-beta receptor | |||
| Lymphotoxin Beta Receptor is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs. The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. | |||
| M55566
|
EPIC-0628 | EPIC-0628 | Histone Methyltransferase |
| EPIC0628 | |||
| EPIC-0628 是一种 HOTAIR-EZH2 相互作用的抑制剂，并能够促进 ATF3 表达。EPIC-0628 EPIC-0628 还抑制 ATF3-p38-E2F1 DDR 通路来抑制 HR 通路，并上调 CDKN1A (p21) 表达，引起细胞周期阻滞。 | |||
| M55646
|
Recombinant Human CDH16 Protein (HEK293, C-6His) | 重组人CDH16 蛋白 (HEK293, C-6His) | Cytokines and Growth Factors |
| Cadherin-16 | |||
| Cadherin-16 (CDH16) is a single-pass type I membrane protein which contains six cadherin domains. CDH16 is exclusively expressed in kidney, where the protein functions as the principal mediator of homotypic cellular recognition. It plays a role in the morphogenic direction of tissue development. | |||
| M56749 | CPDA | CPDA | Phosphatase |
| CPDA是一种新型有效的 SH2 domain-containing inositol phosphatase 2 (SHIP2) 抑制剂, 作用于3T3-L1脂肪细胞, 能够有效改善胰岛素抗性。 | |||
| M57289
|
Recombinant Human ITGB1 (HEK293, C-6His) | 整合素β1；整合素Β1蛋白 | Cytokines and Growth Factors |
| Integrin Beta-1; Integrin β-1; CD29 | |||
| Integrin β-1 (ITGB1) belongs to the integrin β chain family. ITGB1 is an integrin unit associated with very late antigen receptors, which contains one VWFA domain. It is known to conjoin with α-3 subunit to create α3β1 complex that reacts to such molecules as netrin-1 and reelin. | |||
| M58605
|
Collagen Type I (rat tail) | 鼠尾胶原蛋白I型 (rat tail) | Cell Culture |
| 鼠尾胶原蛋白I型 (rat tail) 是一种从SD大鼠鼠尾组织中提取的胶原蛋白。I型胶原蛋白（Collagen, Type I）结构上是由2个α1链和1个α2链组成300 nm长的异源多聚体。当用作凝胶时，胶原蛋白有助于体外培养并增强细胞特异性形态和功能的表达。胶原蛋白也可用于薄层以促进附着，应用包括研究肿瘤细胞侵袭和迁移，单核细胞，巨噬细胞的培养或分化研究。 | |||
