重组人/小鼠/大鼠含纤连蛋白III型域蛋白5由哺乳动物表达系统生产,编码Asp32-Glu143的目标基因在C端有一个6His标签表达。蛋白编号:Q8NAU1。
别名:Fibronectin type III domain-containing protein 5
种属:Human/Mouse/Rat
表达系统:Mammalian
纯度:通过还原SDS-PAGE测定,大于95%
内毒素:经LAL测试,小于0.1 ng/µg(1 EU/µg)
分子量:13.4 KDa
存储及稳定性:冻干的蛋白质应储存在<-20°C,尽管在室温下可稳定3周。重组的蛋白质溶液可在4-7°C储存2-7天。重组的样品等分在<-20°C下可稳定3个月。
生物活性:含纤连蛋白III型结构域的蛋白5,是鸢尾花素的前体,是由FNDC5基因编码的蛋白。人类鸢尾花素合成为一个212个氨基酸(aa)的前体,编码一个1型跨膜蛋白,有121个细胞外结构域(ECD),21个跨膜结构域和39个细胞质结构域。Irisin的ECD包含一个纤连蛋白III型结构域和多个糖基化位点。Irisin诱导过氧化物酶增殖体激活受体γ辅助因子1α(PGC1α)和解偶联蛋白1(UCP1)的表达,这是一种线粒体相关的代谢蛋白。Irisin诱导白色脂肪组织转变为代谢更活跃的米色脂肪组织。Irisin还调节大脑中神经细胞的分化和神经元的生长,并参与骨细胞的分化。
溶解性(25°C) | It is not recommended to reconstitute to a concentration less than 100μg/ml. |
储存条件 |
粉末型式 -20°C 3年;4°C 2年 溶于溶剂 -80°C 6个月;-20°C 1个月 |
运输方式 | 冰袋运输,根据产品的不同,可能会有相应调整。 |
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