找到约 31 条 “3-TYP” 相关结果 （用时 0.264 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M8978
|
3-TYP | 3-TYP | Sirtuin |
| 3-(1H-1,2,3-triazol-4-yl) pyridine; 3TYP | |||
| 3-TYP是一种选择性的SIRT（Sirtuin）3抑制剂，比对 SIRT1 和 SIRT2 的选择性强，3-TYP对SIRT1、SIRT2、SIRT3的IC50值分别为88 nM、92 nM和16 nM。 | |||
| M53429 | Bax BH3 peptide (55-74), wild type | Bax BH3 peptide (55-74), wild type | Apoptosis |
| Bax BH3 peptide (55-74), wild type 是一种含 20 个氨基酸的 Bax BH3 肽 (Bax 1)，能够在多种细胞系模型中诱导细胞凋亡。 | |||
| M2106
|
Azilsartan | 阿齐沙坦 | Angiotensin Receptor |
| TAK-536 | |||
| Azilsartan (TAK-536) 是一种口服有效的、选择性和特异性的 angiotensin II type 1 (AT1)（血管紧张素II 1型）受体拮抗剂，IC50为2.6 nM。Azilsartan 诱导 HepG2 细胞 ROS 形成和细胞凋亡。 | |||
M2805
|
LDN-193189 dihydrochloride | LDN-193189 dihydrochloride | ALK |
| DM-3189 dihydrochloride | |||
| LDN-193189 dihydrochloride 是一种选择性BMP信号抑制剂,它能抑制BMP type I receptors ALK2和ALK3的转录活性，其 IC50 为 5 nM 和 30 nM, 并且对于BMP的选择性是对TGF-β选择性的200倍。此外，LDN-193189与CHIR99021，PD0325901;SB-431542和Forskolin合用，可将成纤维细胞直接转化为褐色脂肪细胞。 | |||
| M4545
|
Isorhamnetin-3-O-neohespeidoside | Isorhamnetin-3-O-neohespeidoside | Others |
| Isorhamnetin-3-O-neohespeidoside 是一种从 Pollen typhae 分离的黄酮类化合物。 | |||
| M5288
|
UK-371804 | UK-371804 | Cathepsin |
| UK-371804是一种有效的urokinase-type plasmogen activator (uPA)抑制剂，Ki为10 nM，其选择性良好，对uPA的选择性比对tPA高4000倍，比对plasmin高2700倍。 | |||
| M7034
|
NNC 55-0396 dihydrochloride | NNC 55-0396 dihydrochloride | Calcium Channel |
| NNC 55-0396 dihydrochloride is a highly selective Ca 2+ channel blocker (T-type). | |||
| M7156 | PPY A | PPY A | Others |
| PPY A is a potent inhibitor of Abl T315l mutant and wild-type Abl kinases. | |||
| M7217 | RS 100329 hydrochloride | RS 100329 hydrochloride | Others |
| RS 100329 hydrochloride is a potent, subtype-selective α 1A antagonist. | |||
| M7328 | SR 33805 oxalate | SR 33805 oxalate | Others |
| SR 33805 oxalate is a ca 2+ channel blocker; binds allosterically to distinct site on L-type channels. | |||
| M7420 | TP 003 | TP 003 | Others |
| TP 003 is a functionally selective GABA A receptor (α3 subtype) partial agonist. | |||
| M7897 | L-838,417 | L-838,417 | Others |
| L-838,417 is a novel pharmacology with no efficacy at a 1 subtype, but is partial agonist with equal efficacy at α2, K3 and α5 subtypes. | |||
| M7908 | MRS 1523 | MRS 1523 | Adenosine Receptor |
| MRS1523 | |||
| MRS 1523是一种有效的选择性腺苷A3受体的拮抗剂，对人和大鼠 A3 受体的 Ki 值分别为 18.9 nM 和 113 nM。因此，MRS 1523能够在不影响其他腺苷受体亚型功能的情况下，特异性地调节A3受体介导的生理效应。MRS 1523还是N-type Ca2+通道的阻滞剂。 | |||
| M8214 | CGP 37849 | CGP 37849 | Others |
| CGP 37849 induces phencyclidine-like behavioral syndrome in amygdala-kindled rats that includes ataxia, locomotion and stereotypies. | |||
| M8614 | MAY0132 | MAY0132 | Others |
| MAY0132 is a selective inhibitor of the cAMP-binding Protein EPAC2 (Exchange Protein directly Activated by Cyclic AMP) subtype 2. | |||
| M40806
|
Anti-Mouse NK1.1 Antibody In vivo | Anti-Mouse NK1.1 Antibody In vivo | Others |
| This NK1.1 antibody (clone PK136) recognizes mouse NK1.1. NK1.1 is a type II membrane protein that is part of the C-type lectin superfamily. | |||
| M10026
|
Futibatinib (TAS-120) | 福巴替尼 | FGFR |
| TAS-120 | |||
| Futibatinib (TAS-120) 是一种口服生物利用度高、选择性强、不可逆的 FGFR 抑制剂，对 FGFR 1-4 的 4 个亚型的 IC50 分别为 3.9、1.3、1.6 和 8.3 nM。Futibatinib 抑制突变型和野生型 FGFR2，且 IC50 相似 (wild-type FGFR2=0.9 nM; V5651=1-3 nM; N550H=3.6 nM; E566G=2.4 nM)。 | |||
| M13605
|
AUZ 454 | AUZ 454 | CDK |
| K03861 | |||
| AUZ 454 (K03861) 是一个 type II CDK2 的抑制剂，Kd 值是 8.2 nM。 | |||
| M43974
|
Recombinant Human Wnt3a Protein (HEK293) | 重组人Wnt3a 蛋白 (HEK293) | Cytokines and Growth Factors |
| Wnt Surrogate-Fc Fusion Protein | |||
| Wnt-3a is one of 19 vertebrate members of the Wingless-type MMTV integration site (Wnt) family. WNT signaling plays key roles in the control of development, homeostasis, and regeneration of many essential organs and tissues. | |||
| M19867
|
Gatifloxacin hydrochloride | Gatifloxacin hydrochloride | Topoisomerase |
| AM-1155 hydrochloride; CG5501 hydrochloride; BMS-206584 hydrochloride; PD135432 hydrochloride | |||
| Gatifloxacin (AM-1155, CG5501, BMS-206584, PD135432) hydrochloride is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases with IC50 of 13.8 μg/ml and 0.109 μg/ml for S. aureus topoisomerase IV and E. coli DNA gyrase, respectively. | |||
| M20083 | WAY-313218 | WAY-313218 | Others |
| WAY-313218 is a 11β-hydroxysteroid dehydrogenase type 1 modulator | |||
| M20617 | ATI-2341 | ATI-2341 | CXCR |
| ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. | |||
| M20688 | B-Raf inhibitor 1 (Compound 13) dihydrochloride | B-Raf inhibitor 1 (Compound 13) dihydrochloride | Raf |
| B-Raf inhibitor 1 (Compound 13) is a type IIA Raf inhibitor which bind to the DFG-out conformation with ki of 1 nM,1 nM,and 0.3 nM for B-Raf(WT), B-Raf(V600E) and C-Raf, respectively. | |||
| M20689
|
Sparsentan (RE-021) | 斯帕森坦 | Endothelin Receptor |
| PS-433540; RE-021; DARA-a; BMS-346567 | |||
| Sparsentan (PS-433540, RE-021, DARA-a, 斯帕森坦) 是一种首创的（first-in-class）、口服活性的、高亲和力的内皮素 A（Endothelin Type A，ETA)和血管紧张素 II（Angiotensin II Subtype 1，AT1)受体双重拮抗剂，Ki 值分别为 9.3和0.8 nM。 | |||
| M21394 | GSK3368715 3HCl | GSK3368715 3HCl | Others |
| GSK3368715 是一种有效的 type I protein arginine methyltransferases (PRMT) 抑制剂，可抑制PRMT1、3、4、6和8，对应的Kiapp值在1.5 nM到81 nM之间。 | |||
| M21670
|
Recombinant Mouse/Rat VEGF-C Protein (HEK293, aa 108-223, Fc Tag) | 重组小鼠/大鼠VEGF-C蛋白 (HEK293, aa 108-223, Fc Tag) | Cytokines and Growth Factors |
| Vascular endothelial growth factor C | |||
| Recombinant Mouse/Rat VEGF-C Protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC), the ED50 is typically 70-300 ng/mL. | |||
| M21671
|
Recombinant Mouse/Rat VEGF-C Protein (HEK293, aa 108-223, His Tag) | 重组小鼠/大鼠VEGF-C蛋白 (HEK293, aa 108-223, His Tag) | Cytokines and Growth Factors |
| Vascular endothelial growth factor C | |||
| Recombinant Mouse/Rat VEGF-C Protein is a dimeric glycoprotein, as a ligand for two receptors, VEGFR-3 (Flt4), and VEGFR-2. VEGF-C may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis. Measured in a cell proliferation assay using human umbilical vein endothelial cells (HUVEC), the ED50 for this effect is typically 0.1-0.8 μg/mL. | |||
| M22459
|
Recombinant Human EGF Protein (HEK293, hFc) | 重组人EGF蛋白 (HEK293, hFc) | Cytokines and Growth Factors |
| EGF is the founding member of the EGF-family of proteins. EGF is a growth factor that stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. It results in cellular proliferation, differentiation, and survival. Measured in a cell proliferation assay using Balb/C 3T3 mouse embryonic fibroblast cells, the ED50 for this effect is typically 0.3-1.5 ng/mL. | |||
| M25261 | Teplizumab | Teplizumab | Others |
| MGA-031; PRV-031 | |||
| Teplizumab (MGA-031) 是一种 Fc 受体型、非结合类型的抗-人 CD3 的单克隆抗体。Teplizumab 可缓解 β 细胞的功能丧失。Teplizumab 可用于 type 1 型糖尿病的研究。 | |||
| M29174 | CHMFL-ABL/KIT-155 | CHMFL-ABL/KIT-155 | Src-bcr-Abl |
| CHMFL-ABL-KIT-155 | |||
| CHMFL-ABL/KIT-155 (CHMFL-ABL-KIT-155; compound 34) 是一种高效的，具有口服活性的 type II ABL/c-KIT 双激酶抑制剂 (IC50 分别为 46 nM 和 75 nM)，对 BLK (IC50=81 nM), CSF1R (IC50=227 nM), DDR1 (IC50=116 nM), DDR2 (IC50=325 nM), LCK (IC50=12 nM), PDGFRβ (IC50=80 nM) 激酶也具有明显的抑制活性。 | |||
| M41781 | Allisartan isoproxil | Allisartan isoproxil | Angiotensin Receptor |
| Allisartan isoproxil (ALS-3) 是一种口服有效的、选择性的、血管紧张素 II 型 1 受体 (Angiotensin II Type 1) 的非肽抑制剂。 | |||
