This NK1.1 antibody (clone PK136) recognizes mouse NK1.1. NK1.1 is a type II membrane protein that is part of the C-type lectin superfamily.
This NK1.1 antibody (clone PK136) recognizes mouse NK1.1. NK1.1 is a type II membrane protein that is part of the C-type lectin superfamily. NK-1.1 is encoded by the NKR-P1B/NKR-P1C gene and expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. NK1.1 contains a transmembrane domain and a cytoplasmic domain that are characteristic of C-type lectins.
The function of NK cells is to mediate cytotoxicity and to secrete cytokines after immune stimulation. NK1.1 has been correlated with lysis of tumor cells In vitro and rejection of bone marrow allografts In vivo. It is also involved in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 is commonly used as a mouse NK cell marker.
Flow Cytometry: The suggested use of this NK1.1 antibody is ≤ 0.25 µg per 106 cells in 100 µl volume.
Clone：PK136
Formulation：PBS pH 7.2 - 7.4
Reactivity Species：Mouse
Host Species：Mouse
Product Concentration：≥ 5.0 mg/ml
Endotoxin：< 1.0 EU/mg
Purity：≥95%
| 储存条件 |
Stored sterile as received at 2-8°C for up to one month. For longer term storage, store at -80°C without diluting. Avoid Repeated Freeze Thaw Cycles. |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
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