Wnt-3a is one of 19 vertebrate members of the Wingless-type MMTV integration site (Wnt) family. WNT signaling plays key roles in the control of development, homeostasis, and regeneration of many essential organs and tissues.
别名：Wnt Surrogate-Fc Fusion Protein
Wnt-3a is one of 19 vertebrate members of the Wingless-type MMTV integration site (Wnt) family. WNT signaling plays key roles in the control of development, homeostasis, and regeneration of many essential organs and tissues. Endogenous WNTs bind to multiple FZDs and are heavily modified posttranslationally, making them difficult to manufacture consistently. WNT surrogate molecules phenocopied endogenous ligand activities in in vitro reporter assays and intestine organoid functional assays.
Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells, the ED50 for this effect is 71.45 ng/ml.
Endotoxin < 0.01 EU/µg
Apparent Molecular Weight: 66-73kDa, reducing conditions
Supplied as a 0.2 μm filtered solution of 25mM Tris-HCl, 500mM NaCl, pH8.2.
The product is shipped on dry ice. Upon receipt, store it immediately at the temperature listed below.
| 性状 | Solution |
| 储存条件 | Store at ≤ -70°C, stable for 6 months after receipt. |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
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