找到约 33 条 “17-PA” 相关结果 （用时 0.213 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M6319
|
17-PA | 17-PA | GABA Receptor |
| 17-PA是一种选择性拮抗剂的神经类固醇增强和直接门控的GABAA受体。与5β-还原类固醇相比，选择性地降低5α-还原类固醇的作用，对巴比妥类药物和苯二氮卓类药物诱发的增强作用无影响。减轻i.c.v后大鼠3α，5α- thp诱导的翻正反射和总睡眠时间的丧失。 | |||
| M9534
|
TAS6417 | TAS6417 | EGFR/HER2 |
| TAS-6417; Zipalertinib; CLN-081 | |||
| TAS6417是一个靶向外显子20插入突变的新型的EGFR抑制剂，其IC50值为1.1-8.0 nM。 | |||
| M11838 | ChemBridge-5216177 | ChemBridge化合物-5216177 | Screening Compounds and Building Blocks |
| 10-[(1-methyl-3-piperidinyl)methyl]-10H-phenothiazine dihydrochloride (5216177) | |||
| ChemBridge特有类药化合物/先导化合物-5216177，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M52930 | [Arg-15, 20, 21, Leu17]-PACAP-Gly-Lys-Arg-NH2 | [Arg-15, 20, 21, Leu17]-PACAP-Gly-Lys-Arg-NH2 | Others |
| [Arg-15,-20,-21,Leu17]-PACAP-Gly-Lys-Arg-NH2 (BM-PACAP) 是合成的 PACAP 1-27 类似物，具有松弛作用。 | |||
| M1910
|
Nepicastat hydrochloride | 盐酸内匹司他 | Dopamine Receptor |
| SYN117 | |||
| Nepicastat (SYN-117) HCl是一种有效的，选择性的牛和人类dopamine-β-hydroxylase（多巴胺-β-羟氨）抑制剂，IC50分别为8.5 nM和9 nM，对12种其他酶13种神经递质受体几乎没有亲和力。 | |||
| M2152
|
Carfilzomib | 卡非佐米 | Proteasome |
| PR-171 | |||
| Carfilzomib (PR-171)是一种不可逆的蛋白酶体 (proteasome) 抑制剂，IC50为<5 nM，在体外优先抑制β5亚基的ChT-L活性，对PGPH和T-L活性很弱或没有作用。*该产品在溶液状态不稳定，建议您现用现配 | |||
| M2576
|
VU 0361737 | VU 0361737 | GluR |
| ML-128 | |||
| VU 0361737是一种选择性(PAM)mGlu4受体正变构调节剂(PAM)，作用于人类和大鼠受体，EC50分别为240 nM和110 nM，对mGlu5和mGlu8受体具有微弱的作用活性，抑制mGlu1， mGlu2， mGlu3， mGlu6 and mGlu7受体活性，可以渗透进入CNS。 | |||
| M2766
|
IEM 1754 dihydrobromide | IEM 1754 dihydrobromide | GluR |
| IEM 1754 dihydrobroMide是一种选择性AMPA/kainate受体抑制剂，作用于GluR1和GluR3，IC50为6 μM。 | |||
| M5533
|
Corticosterone | 皮质酮；皮质甾酮 | GCR |
| 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B | |||
| Corticosterone (17-Deoxycortisol) 是一种具有口服活性的，由肾上腺皮质产生的糖皮质激素，在调节边缘系统的神经元功能方面起着重要作用。Corticosterone 皮质酮可通过 SGK 诱导的 GDI 磷酸化增加 Rab 介导的 AMPAR 膜运输。 | |||
| M7000 | MRS 2179 tetrasodium salt | MRS 2179 tetrasodium salt | P2 Receptor |
| MRS 2179四钠盐是P2Y1受体的竞争性拮抗剂(KB = 100 nM)。对P2X1 (IC50 = 1.15 μM)、P2X3 (IC50 = 12.9 μM)、P2X2、P2X4、P2Y2、P2Y4和P2Y6受体的选择性。通过ATPγS抑制ntpase e1的上调。 | |||
| M7104
|
PD 146176 | PD 146176 | Ferroptosis |
| PD146176 | |||
| PD 146176是一种选择性的15-脂氧合酶（15-LOX）抑制剂，以及铁死亡（ferroptosis）抑制剂。同时还具有很强的抗增殖活性，能导致细胞周期停滞在G1期，以及caspases 3/7活性增加（＞50倍）。此外，PD 146176还可抑制兔网织红细胞15-LOX，Ki为197 nM，用于动脉粥样硬化的相关研究。 | |||
| M7362 | TC NTR1 17 | TC NTR1 17 | Others |
| TC NTR1 17 is a selective NTS 1 partial agonist. | |||
| M7894 | LY311727 | LY311727 | Others |
| LY311727 is an orally active; potent secretory Phospholipase A2 (sPLA2; Group IIa) inhibitor. | |||
| M7897 | L-838,417 | L-838,417 | Others |
| L-838,417 is a novel pharmacology with no efficacy at a 1 subtype, but is partial agonist with equal efficacy at α2, K3 and α5 subtypes. | |||
M7934
|
MDL 28170 | MDL 28170 | Gamma-secretase/Beta-secretase |
| Calpain Inhibitor III | |||
| MDL-28170 (Calpain Inhibitor III) 是一种有效的、选择性的、具有膜渗透性的半胱氨酸蛋白酶 (calpain)抑制剂，可穿过血脑屏障。MDL-28170 还能阻断γ-secretase。 | |||
| M8210 | FR-171113 | FR-171113 | Others |
| FR171113 was the first non-peptide antagonist of the Protease Activated Receptor-1 (PAR1), also termed thrombin receptor. | |||
| M8329
|
PD 151746 | PD 151746 | Calpain |
| PD151746 | |||
| PD151746是一种钙蛋白酶抑制剂，抑制 u-calpain (Ki = 0.26 ± 0.03 μM) 选择性比抑制 m-calpain (Ki = 5.33 ± 0.77μM) 高20倍。 | |||
| M8389 | SR 27417 | SR 27417 | Others |
| SR 27417 is a long-acting, highly potent, specific competitive platelet-activating factor (PAF) receptor antagonist. | |||
| M8618 | KT172 | KT172 | Others |
| KT172 is a Diacylglycerol lipase (DAGL) inhibitor selective for DAGLβ. | |||
| M8641 | LP117 | LP117 | Others |
| LP117 is a pirinixic acid derivative that interferes with ATP-binding cassette (ABC) transporter ABCB1-mediated substrates transport, including vincristine, vinorelbine, paclitaxel, and actinomycin D, but not doxorubicin, rhodamine 123, or JC-1. | |||
| M8662 | PDD00017273 | PDD00017273 | Others |
| PDD-17273 | |||
| PDD00017273 是一种有效的、选择性的聚（ADP-核糖）糖水解酶 poly (ADP ribose) glycohydrolase (PARG)抑制剂，IC50为26 nM。PDD00017273催化 ADP-核糖聚合物的 O-糖苷键的水解，逆转聚（ADP-核糖）聚合酶 (PARP) 的作用。 | |||
| M9376
|
Dapansutrile (OLT1177) | Dapansutrile (OLT1177) | Pyroptosis |
| OLT1177 | |||
| Dapansutrile (OLT1177) 是一种首创的（first-in-class），有效的，具有口服活性的选择性NLRP3炎性小体抑制剂。此外，Dapansutrile也能抑制细胞焦亡 (pyroptosis) 。 | |||
| M10186
|
Leniolisib | 莱尼利西布 | PI3K |
| CDZ173 | |||
| Leniolisib (CDZ173，莱尼利西布) 是一种首创的(first-in-class)，有效的，选择性PI3Kδ抑制剂，其IC50值为11 nM。Leniolisib对PI3K-δ的选择性高于PI3K-α（28 倍）、PI3K-β（43 倍）和PI3K-γ（257 倍）。在细胞测定中，Leniolisib降低了pAKT通路活性并抑制了B细胞和T细胞亚群的增殖和激活。 | |||
| M11056
|
NSC 617145 | NSC 617145 | DNA/RNA Synthesis |
| NSC 617145 是一种选择性 werner 综合征解旋酶 (WRN) 解旋酶抑制剂，IC50 值为 230 nM。NSC 617145 抑制 WRN ATPase，并诱导双链断裂 (DSB) 和染色体异常。NSC 617145 对 WRN 具有选择性，优于 BLM、FANCJ、ChlR1、RecQ 和 UvrD 解旋酶。 | |||
| M10956 | PAT-1251 | PAT-1251 | Monoamine Oxidase |
| PAT-1251 是一种有效的，选择性的，可口服的赖氨酰氧化酶样蛋白 2 (LOXL2) 抑制剂，对 hLOXL2 和 hLOXL3 的 IC50 值分别为 0.71 和 1.17 μM，同时对小鼠、大鼠和狗 LOXL2 的抑制作用很强，IC50 值分别为 0.10，0.12 和 0.16 μM；PAT-1251 可用于多种纤维性疾病的研究。 | |||
| M11255
|
DG172 dihydrochloride | DG172 dihydrochloride | PPAR |
| DG172 dihydrochloride 是一种选择性的 PPARβ/δ 拮抗剂，IC50 值为 27 nM。 | |||
| M13950 | Quinpirole Hydrochloride | Quinpirole Hydrochloride | Dopamine Receptor |
| (-)-LY 171555 | |||
| Quinpirole Hydrochloride ((-)-LY 171555) 是具有高亲和力的 dopamine D2/D3 受体的激动剂。 | |||
| M20545 | 17-Beta-Estradiol-3,17-Dipropionate | 17-Beta-Estradiol-3,17-Dipropionate | Estrogen Receptor |
| Estradiol dipropionate (17-Beta-Estradiol-3,17-Dipropionate) is a semisynthetic, steroidal estrogen which has been used in hormone therapy for menopausal symptoms and low estrogen levels in women and in the treatment of gynecological disorders. | |||
| M20686 | SIB 1757 | SIB 1757 | GluR |
| SIB 1757 is a highly selective, noncompetitive antagonist of metabotropic glutamate receptor type 5 (mGluR5) with IC50 of 0.4 μM at hmGluR5 compared with >30 µM at hmGluR1b, hmGluR2, hmGluR4, hmGluR6, hmGluR7 and hmGluR8. | |||
| M20734 | (E/Z)-BCI | (E/Z)-BCI | Phosphatase |
| BCI, NSC 150117 | |||
| (E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells. | |||
| M20806 | EN4 | EN4 | Others |
| EN4, a covalent ligand that targets cysteine 171 (C171) of MYC, is selective for c-MYC over N-MYC and L-MYC. EN4 inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis. | |||
| M20842 | C-171 | C-171 | STING |
| C-171 is a covalent small-molecule inhibitor of STING. C-171 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING. | |||
| M20995 | DDD107498 | DDD107498 | Others |
| M-5717, DDD-498 | |||
| DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite. | |||
