Corticosterone  别名：17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B; 皮质酮

Corticosterone (17-Deoxycortisol) 是一种具有口服活性的，由肾上腺皮质产生的糖皮质激素，在调节边缘系统的神经元功能方面起着重要作用。Corticosterone 皮质酮可通过 SGK 诱导的 GDI 磷酸化增加 Rab 介导的 AMPAR 膜运输。Corticosterone作用于单胺转运体, 有效抑制有机阳离子转运体。Corticosterone 还能干扰树突状细胞的成熟，具有较好的免疫抑制活性。

在体内，Corticosterone 皮质酮导致BMDC细胞诱导新生CD8+T细胞的能力明显下降。Corticosterone 皮质酮（0.03或1mg/kg；s.c.；单次）可下调大鼠齿状回和CA1的BDNF mRNA表达。

动物实验配制方法剂量（摘自公开文献，仅供参考）

1) ICR mice (male, 7 weeks old, weighing 25–28 g) were purchased from KOATECH Animal Inc. The mice had ad libitum access to food and water in a climate-controlled chamber (temperature, 21 ± 2 °C and light–dark cycle, 24 h, lights on at 07:00, and lights off at 19:00). All mice (n = 4 per cage) were habituated to the facility for 1 week prior to starting the experiments. To induce depression-like behavior, a high dose of CORT was intraperitoneally (i.p.) injected according to a previous study. CORT was dissolved in 0.9% (w/v) saline containing 0.1% dimethyl sulfoxide (DMSO) and 1% Tween-80. St. John’s wort (80% MeOH extract, dried powder of Hypericum japonicum), which was the positive control, and PRE was dissolved in distilled water. The mice were randomly assigned to six groups (n = 8): (1) sham, (2) control, (3) St. John’s wort 300 mg/kg, (4) PRE 30 mg/kg, (5) PRE 100 mg/kg, and (6) PRE 300 mg/kg. Mice in the control and sample-treated groups were administered CORT (40 mg/kg, i.p.) once daily, while those in the sham group were treated with an equal volume of vehicle.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182056/

2) Male ICR mice weighing 18–22 g were procured from the Hunan Slac Animal Center, Changsha, China. The mice were housed ten per cage except for the sucrose preference test. The environment was maintained with a 12-h light/dark cycle (08:00–20:00). Ambient temperature and relative humidity were maintained at 22 ± 2 °C and at 40%–60%. The mice had free access to drink and food. After one week of adaptation, the mice were randomly divided into six groups (n = 10): (1) Control group: saline (p.o) + saline (s.c); (2) CORT-vehicle group: saline (p.o) + CORT (s.c); (3) Res group: resveratrol (50 mg/kg, p.o) + CORT (s.c); (4) Res group: resveratrol (100 mg/kg, p.o) + CORT (s.c); (5) Flu group: fluoxetine (20 mg/kg, p.o) + CORT (s.c); (6) Piog group: pioglitazone (10 mg/kg, p.o) + CORT (s.c). The dose of CORT was 40 mg/kg. The preparation of CORT solution was in line with our previous study. In brief, the CORT was dissolved in a saline solution containing 0.1% dimethyl sulfoxide and 0.1% Tween-80.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274283/