M4614
|
Orientin |
Orientin（荭草苷）是一种可从药用植物中分离的生物活性化合物，能有效地抑制Sortase A的活性，其IC50为50.44 ± 0.51 µM。还可以通过Nrf2以及JNK/cytochrome c/caspase-3信号通路，抑制APAP诱导的肝细胞氧化损伤和线粒体功能障碍，具有抗氧化，抗炎和抗癌活性。 |
| M9358
|
ITE |
ITE是一种有效的，内源性的芳烃受体（AhR）的激动剂，可直接与AhR结合，Ki为3 nM。 |
| M10093
|
α-Galactosyl Ceramide |
α-Galactosyl Ceramide (KRN 7000, alpha-GalCer) α-半乳糖神经酰胺 是一种强大的NKT细胞刺激剂，和选择性CD1d配体。α-Galactosylceramide (α-GalCer) 是一种合成的糖脂，具有抗肿瘤和免疫刺激作用。 |
| M1831
|
Cyclosporine A |
Cyclosporine A （环胞霉素A; 环孢菌素 A; CsA; Cyclosporin A）是一种免疫抑制剂和钙调素磷酸酶抑制剂，Cyclosporine A能够抑制T淋巴细胞的增殖和分化，以及抑制IL-2、IFN-γ等细胞因子的分泌，目前主要用于狼疮肾炎、风湿性关节炎、银屑病等炎症性和自身免疫性疾病的研究，以及器官移植研究。 |
| M20413
|
4-Biphenylacetic acid |
4-Biphenylacetic acid (BPA) is a potential non-steroidal anti-inflammatory agent and forms solid inclusion complex with β-cyclodextrin. Its interaction with quinolone antibacterial agents can induce functional blockade of the γ-aminobutyric acid receptors. |
| M25413
|
Fucoxanthin |
岩藻黄质 Fucoxanthin 是一种天然存在于某些藻类中的类胡萝卜素，具有抗肥胖、抗氧化、抗糖尿病、抗癌和抗炎活性。 |
| M55368
|
2-Hydroxy Fluorene |
2-Hydroxy Fluorene (2-FLU) 在生命科学相关研究中具有广泛的应用。2-FLU 可以增加 HaCaT 细胞中牛皮癣相关炎症因子的表达。 |
| M55040
|
Litifilimab |
Litifilimab 是一种靶向 C 型凝集素域家族 4 成员 C（CLEC4C）的人源化 IgG1-κ 抗体。 |
M44564
|
Tembetarine |
藤泊它碱 Tembetarine 具有消炎和抗损伤的特性，并可作为一种抗蚜虫剂。 |
| M40934
|
Anti-Mouse CTLA-4 Antibody (Clone 9D9) In vivo |
Anti-Mouse CTLA-4 Antibody (Clone 9D9) recognizes an epitope on mouse CTLA-4. CTLA-4 is expressed on activated T and B lymphocytes. |
| M40918
|
Anti-Mouse Ly6G Antibody (Clone 1A8) In vivo |
Anti-Mouse Ly6G antibody (Clone 1A8) In vivo recognizes an epitope on mouse Ly6G. Ly6G is expressed by neutrophils. |
| M40909
|
Anti-Mouse CD8a Antibody (Clone 53-6.7) In vivo |
Anti-Mouse CD8a Antibody (Clone 53-6.7) In vivo recognizes Lyt 2. Clone 53-6.7 competes with clone 5H10-1 for binding to thymocytes. |
| M40830
|
Anti-Mouse CD3ε Antibody In vivo |
Anti-Mouse CD3ε Antibody (Clone 145-2C11) In vivo单克隆抗体与小鼠CD3ε反应。小鼠CD3ε是一种20 kDa的跨膜细胞表面蛋白，属于免疫球蛋白超家族。 |
| M40828
|
Anti-Mouse CTLA-4 Antibody (Clone 9H10) In vivo |
抗鼠CTLA-4抗体（克隆9H10）识别小鼠CTLA-4上的表位。CTLA-4在活化的T和B淋巴细胞上表达。 |
| M40812
|
Anti-Mouse Ly-6G/Ly-6C Antibody (Clone RB6-8C5) In vivo |
Anti-Mouse Ly-6G/Ly-6C Antibody (Clone RB6-8C5) In vivo has been used to identify peripheral blood neutrophils and deplete granulocytes in vivo. |
| M21680
|
TJ-M2010-5 |
TJ-M2010-5 是一种 MyD88 抑制剂，可与 MyD88 的 TIR 结构域结合以干扰其同源二聚化和 TLR/MyD88 信号通路。 |
| M21029
|
MRE-269 |
MRE-269 是一种选择性的 prostaglandin I2 (IP) 受体激动剂。 |
| M20985
|
Perflubron |
Perflubron (1-Bromoperfluorooctane, Perfluorooctyl bromide, Oxygent, PFOB) exhibits anti-inflammatory activity thus decreases cytokine production in human alveolar macrophages. Perflubron also attenuates oxidative damage to both biological and nonbiological systems which is independent of its anti-inflammatory properties. |
| M20958
|
Talniflumate |
Talniflumate是niflumic acid的前药，也是一种新型的，选择性的核心粘蛋白合成酶（GCNT3）抑制剂，同时具有抗炎和止痛活性，可用于囊性纤维化、慢性阻塞性肺病（COPD）和类风湿性关节炎等的相关研究。 |
| M20561
|
Picolinic acid (PCL 016) |
PCL016 is a pyridine carboxylate metabolite of tryptophan and acts as an anti-infective and immunomodulator. It acts by binding with the zinc associated with zinc finger proteins to alter their structure and inhibit function. |
| M20433
|
Tolmetin |
Tolmetin is a nonsteroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class and also exhibits analgesic and antipyretic activity. |
| M20432
|
5-Acetylsalicylic acid |
5-Acetylsalicylic acid is an aminosalicylate anti-inflammatory agent, which has anti-inflammatory and is considered to be the active agent in inflammatory bowel disease (IBD). |
| M20412
|
NLRP3 Inflammasome Inhibitor I |
NLRP3 Inflammasome Inhibitor I是一种新型的 NLRP3 炎症小体抑制剂，同时也是格列苯脲合成过程中的中间底物，不含参与胰岛素释放的环己基脲分子。 |
| M18961
|
Cistanoside F |
Cistanoside F 肉苁蓉苷F 是一种从肉苁蓉分离得到的苯乙醇苷类化合物，具有抗氧化活性。Cistanoside F 含有抗衰老活性成分，如D-甘露醇、肉苁蓉多糖，还含雄性激素样活性成分如甜菜碱、洋丁香酚苷，还含β-谷甾醇、肉苁蓉苷、海胆苷和多种氨基酸等。 |
| M18678
|
Ginsenoside Rk2 |
Ginsenoside Rk2 人参皂苷RK2 是从人参 (SG; Sun Ginseng) 中分离出的达玛烷糖苷，具有抗肿瘤和抗血小板聚集活性。 |
| M18258
|
11beta,13-Dihydrolactucin |
11beta,13-Dihydrolactucin 11b,13-二氢山莴苣素 是一种倍半萜内酯，通过乳糖苷的 11,13-双键正式氢化而获得。它是一种植物代谢物。 |
| M16766
|
Cirsilineol |
Cirsilineol 是一种天然黄酮化合物，可选择性抑制肠道 CD4+ T 细胞中的 IFN-γ/STAT1/T-bet 信号。Cirsilineol 具有免疫抑制和抗肿瘤特性。 |
| M16307
|
Isogosferol |
Isogosferol (异栓翅芹醇) 是一种有效的抗炎剂。Isogosferol 降低 LPS 刺激的 NO 和 IL-1β 表达。Isogosferol 降低 LPS 刺激的 iNOS、COX-2、NF-κB 和 pERK1/2 的表达。 |
