找到约 33 条 “OX Receptor” 相关结果 （用时 0.196 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M21445
|
Recombinant Human OLR1/LOX1 (HEK293, C-6His) | 重组人OLR1/LOX1蛋白 (HEK293, C-6His) | Cytokines and Growth Factors |
| Oxidized Low-Density Lipoprotein Receptor 1; LOX-1 | |||
| Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as LOX1, is a receptor protein that belongs to the C-type lectin superfamily. LOX1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2. | |||
| M29995 | OT-R antagonist 1 | OT-R antagonist 1 | Oxytocin Receptor |
| Oxytocin receptor antagonist 1 | |||
| OT-R antagonist 1是一种新型有效的选择性非肽类OT-R拮抗剂, 抑制催产素诱发的细胞内Ca2+活动（IC50=8nM）。 | |||
| M55236
|
Recombinant Mouse LTBR Protein (HEK293, C-Fc) | 重组小鼠LTBR 蛋白 (HEK293, C-Fc) | Cytokines and Growth Factors |
| Lymphotoxin-beta receptor | |||
| Lymphotoxin Beta Receptor is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs. The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. | |||
| M2088
|
Ciproxifan maleate | Ciproxifan maleate | Histamine Receptor |
| FUB 359 maleate | |||
| Ciproxifan（CPX）是一种高效的，选择性的histamin H3-receptor拮抗剂，IC50为9.2 nM，作用于其他受体亚型具有低亲和力。 | |||
| M2105
|
Azilsartan medoxomil | 阿齐沙坦酯 | Angiotensin Receptor |
| TAK-491 | |||
| Azilsartan Medoxomil是一种有效的angiotensin II type 1 (AT1) receptor（血管紧张素II 1型受体）拮抗剂，抑制RAAS比作用于AT2选择性高10，000倍以上，用于研究高血压。 | |||
| M2280
|
Tamoxifen Citrate (ICI 46474) | 枸橼酸他莫昔芬；柠檬酸三苯氧胺；柠檬酸它莫西芬；柠檬酸他莫昔芬 | Estrogen Receptor |
| ICI 46474; Istubal; Nolvadex | |||
| Tamoxifen Citrate是一种雌激素受体（Estrogen Receptor）拮抗剂，与雌激素竞争性结合。 | |||
M2507
|
Chenodeoxycholic acid | 鹅去氧胆酸 | Farnesoid X Receptor |
| CDCA; Chenodiol | |||
| Chenodeoxycholic Acid是一种天然存在的人体胆汁酸，也是一种法尼类X受体（Farnesoid X Receptor）的激动剂。可用于脑腱黄瘤病(CTX)的相关研究。 | |||
| M2522
|
Ciproxifan | Ciproxifan | Histamine Receptor |
| FUB-359 | |||
| Ciproxifan（CPX）是一种高效的，选择性的histamin H3-receptor拮抗剂，IC50为9.2 nM，作用于其他受体亚型具有低亲和力。 | |||
| M2842
|
Methoxamine hydrochloride | 盐酸甲氧明；凡索昔；美迷克新命；盐酸甲氧胺； | Adrenergic Receptor |
| Vasoxine HCl | |||
| Methoxamine是一种α1-肾上腺素能受体（α1-adrenergic receptor）激动剂，它能诱导皮肤和脾脏血管收缩。 | |||
| M3324
|
SB408124 | SB408124 | OX Receptor |
| SB408124是一种非肽类OX1 receptor拮抗剂，作用于全细胞和膜，Ki分别为57 nM和27 nM，比作用于OX2受体选择性高50倍。 | |||
| M3388
|
Sulfisoxazole | 磺胺异恶唑 | Endothelin Receptor |
| NU-445; Sulfafurazole | |||
| Sulfisoxazole (Sulfafurazole) 是一种具有口服活性的内皮素受体 (endothelin receptor) 拮抗剂，对内皮素受体 A 和 B 的IC50 值分别为 0.60 μM 和 22 μM。Sulfisoxazole 还是磺胺类抗菌剂 (antibacterial)。 | |||
| M3413
|
Phenoxybenzamine hydrochloride | 盐酸酚苄明 | Adrenergic Receptor |
| Phenoxybenzamine HCl（盐酸酚苄明）是一种非选择性的，不可逆α肾上腺素能受体（Adrenergic Receptor）拮抗剂，IC50为550 nM。 | |||
| M1565
|
Quetiapine sulfoxide | 喹硫平硫氧化物；喹硫平亚砜 | 5-HT Receptor |
| Quetiapine sulfoxide; Quetiapine S-oxide | |||
| Quetiapine sulfoxide是一种 5-HT 受体激动剂，对人 5-HT1A 的 pEC50 值为 4.77。Quetiapine hemifumarate 是多巴胺受体 (dopamine receptor) 拮抗剂，对人 D2 的 pIC50 值为 6.33。 | |||
| M4887
|
Pardoprunox Hydrochloride | 盐酸帕多芦诺 | 5-HT Receptor |
| SLV-308 | |||
| Pardoprunox hydrochloride (DU-126891, SME-308)是一种有效的部分 dopamine D2 receptor 的激动剂，对应的pEC50值为8.0，也是诱导 [35S]GTPγS binding 的部分激动剂，对应的pEC50值为9.2，和 serotonin 5-HT1A receptor 的激动剂，pEC50值为6.3。 | |||
| M5828
|
Octinoxate | 对甲氧基肉桂酸辛酯 | Thyroid Hormone Receptor |
| 2-Ethylhexyl 4-methoxycinnamate; Octyl methoxycinnamate | |||
| Octinoxate（对甲氧基肉桂酸辛酯）是一种紫外线过滤剂和甲状腺激素受体（thyroid hormone receptor）的激动剂。Octinoxate 还可以抑制 CYP1A1 和 CYP1B1，IC50值分别约为1 µM和586 nM，并以依赖于 PI3K 通路的方式调节角质形成细胞中的透明质酸代谢。 | |||
| M5843
|
Oxybenzone | Oxybenzone | Apoptosis |
| Benzophenone 3 | |||
| Oxybenzone（Benzophenone-3）能吸收UVB和UVA II射线，导致光化学激发和能量吸收，并可减弱辐射的皮肤穿透性，以及降低DNA损伤的风险。Oxybenzone用作破坏内分泌的化学物质 (EDCs)，并可以穿过胎盘和血脑屏障。 Oxybenzone 损害自噬 (autophagy)，改变表观遗传状态并破坏凋亡神经元细胞中的类维生素 X 受体 (retinoid X receptor) 信号传导。 | |||
| M6833
|
IPSU | IPSU | OX Receptor |
| IPSU is a oX 2 receptor antagonist; orally bioavailable. | |||
| M7174 | PTAC oxalate | PTAC oxalate | Others |
| PTAC oxalate is a muscarinic receptor ligand; exhibits partial agonist and antagonist activity at different subtypes. | |||
| M7213 | Roxindole hydrochloride | Roxindole hydrochloride | Others |
| Roxindole hydrochloride is a dopamine D 2 autoreceptor agonist. Also has affinity for D 3, D 4, 5-HT 1A receptors and the 5-HT transporter. | |||
| M7353
|
Tamoxifen | 他莫昔芬 | Estrogen Receptor |
| ICI47699; Z-Tamoxifen; trans-Tamoxifen | |||
| Tamoxifen是一种选择性雌激素受体调节剂 (Selective estrogen receptor modulators，SERM)，可阻断乳腺细胞中的雌激素作用。Tamoxifen 也是一种有效的 Hsp90 激活剂，可增强 Hsp90 分子伴侣 ATPase 的活性。Tamoxifen 还可以有效抑制传染性 EBOV Zaire 和 Marburg (MARV)，IC50 分别为 0.1 µM 和 1.8 µM。 | |||
| M7410
|
THIP hydrochloride | 加波沙朵盐酸盐 | GABA Receptor |
| Gaboxadol hydrochloride; Lu 02-030 HCl | |||
| THIP hydrochloride (Gaboxadol hydrochloride) 是一种 GABAA receptor 激动剂和 GABAC receptor 拮抗剂，可以作为一种非阿片类的动物实验麻醉剂或镇痛剂。THIP还可用于亨廷顿病、睡眠、厌食等多方面的研究。 | |||
| M7722 | Ciproxifan hydrochloride | 环丙基[4-[3-(1H-咪唑-5-基)丙氧基]苯基]甲酮盐酸盐 | Others |
| Ciproxifan（CPX） belongs to a novel chemical series of histamine H3-receptor antagonists. | |||
| M7769 | Daltroban | 达尔卓潘 | Others |
| Selective thromboxane A2 receptor antagonist. | |||
| M7855 | ICI 192605 | ICI 192605 | Others |
| ICI 192605 is a potent thromboxane A2 receptor antagonist. | |||
| M7946 | Naloxone methiodide | Naloxone methiodide | Others |
| Quaternary salt of naloxone that, like the parent compound, is a nonselective antagonist at opioid receptors. | |||
| M7964
|
Nordihydroguaiaretic acid | 去甲二氢愈创木酸 | Lipoxygenase |
| NDGA | |||
| Nordihydroguaiaretic acid (NDGA) 是一种 5-脂氧合酶 (5LOX) (IC50=8 μM) 和酪氨酸激酶抑制剂，具有抗氧化、清除自由基的活性。Nordihydroguaiaretic acid (NDGA) 是一种具有细胞毒性的 insulin-like growth factor-I receptor (IGF-1R)/HER2 的抑制剂，可诱导细胞凋亡。Nordihydroguaiaretic acid (NDGA) 是一种ABA合成抑制剂。 | |||
| M8048 | Nafoxidine hydrochloride | 盐酸萘福昔定 | Others |
| Nafoxidine is a potent estrogen receptor antagonist that exhibits anti-proliferative properties. | |||
| M8139 | Ridaifen-B | Ridaifen-B | Others |
| Ridaifen-B (RID-B) is a novel tamoxifen (TAM) analog that significantly augments apoptosis-inducing effect of TAM in estrogen receptor (ER)-negatives cells. | |||
| M8150 | SB-668875 | SB-668875 | Others |
| SB-668875 is a novel, selective peptide agonist at OX2 orexin receptors. | |||
| M8234 | Loxiglumide | 氯谷胺 | Others |
| CR-1505 | |||
| Loxiglumide is a small-molecule antagonist of the cholecystokinin receptor CCKA. | |||
| M8366 | DDN | DDN | Others |
| DDN (5,8-Diacetyloxy-2,3-dich |
|||
| M8416 | Darglitazone sodium salt | Darglitazone sodium salt | Others |
| Darglitazone is a highly potent and selective PPAR-γ (peroxisome proliferator-activated receptor-γ) agonist. | |||
| M8482 | Nonyloxytryptamine oxalate | Nonyloxytryptamine oxalate | Others |
| Nonyloxytryptamine (5-nonyloxytryptamine) is a potent and selective 5-HT1B receptor agonist. | |||
