Recombinant Human OLR1/LOX1 (HEK293, C-6His) 别名：Oxidized Low-Density Lipoprotein Receptor 1; LOX-1; 重组人OLR1/LOX1蛋白 (HEK293, C-6His)
Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as LOX1, is a receptor protein that belongs to the C-type lectin superfamily. LOX1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2.
化学性质/溶解性/储存
| 性状 | Lyophilized powder |
| 中文名称 | 重组人OLR1/LOX1蛋白 (HEK293, C-6His) |
| 溶解性 | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| 储存条件 | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
| 运输方式 | 冰袋运输，根据产品的不同，可能会有相应调整。 |
生物活性
Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as LOX1, is a receptor protein that belongs to the C-type lectin superfamily. LOX1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2. Ox-LDL receptor 1 is expressed at high levels in endothelial cells and vascular rich organs such as placenta, lung, liver, brain, intima of the aorta, bone marrow, spinal cord and substantia nigra. Ox-LDL receptor 1 expression is induced by inflammatory cytokines such as TNF, IFNG, and IL6 in the context of hyperlipidemia, hypertension, and diabetes. Ox-LDL receptor-1 mediates the recognition, internalization, and degradation of oxidation-modified low-density lipoproteins (OxLDL) by vascular endothelial cells.
Recombinant Human OLR1/LOX1 expressed the target gene encoding Ser61-Gln273 with a 6His tag at the C-terminus.
Accession: P78380
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 30-35 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
实验参考
建议您制定动物给药及实验方案时，尽量参考已发表的相关实验文献（溶剂种类及配比众多，简单地溶解目的化合物，并不能解决动物给药依从性、体内生物利用度、组织分布等相关问题，未必能保证目的化合物在动物体内充分发挥生物学效用）。
体内实验的工作液，建议您现用现配，当天使用；如在配制过程中出现沉淀、析出现象，可以通过超声和（或）加热的方式助溶。
切勿一次性将产品全部溶解。
请在下面的计算器中，输入您的动物实验相关数据并点击计算，即可得到该实验的总需药量和工作液终浓度。
例如您给药剂量是10 mg/kg，平均每只动物的体重为20 g，每只动物的给药体积是100 μL，动物数量为20只，则该动物实验的总需药量为4 mg，工作液终浓度为2 mg/mL。
1：鉴于实验过程的损耗，建议您至少多配1-2只动物的量；
2：为该产品最终给药时的浓度。
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