找到约 49 条 “OAC1” 相关结果 （用时 0.209 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M2896
|
OAC1 | OAC1 | Others |
| OAC1 (Oct4-activating compound 1)是一种有效的 Oct4 激活剂，能激活 Oct4 和 Nanog 启动子，促进诱导多功能干细胞 (iPSC) 的形成，以及通过上调 HOXB4 表达激活 OCT4。此外，OAC1 还能增加Oct4-Nanog-Sox2 三联体和 TET1 的转录，并可通过提高效率和缩短重编程时间，促进细胞的重编程。 | |||
| M13317 | ChemBridge-81439629 | ChemBridge化合物-81439629 | Screening Compounds and Building Blocks |
| 1-[3-(2-methyl-1-piperidinyl)propyl]-1H-benzimidazole bis(trifluoroacetate) (81439629) | |||
| ChemBridge特有类药化合物/先导化合物-81439629，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M19933
|
Amdinocillin | Amdinocillin | Antibiotic |
| Mecillinam; Coactin; FL 1060 | |||
| Amdinocillin（Mecillinam）是一种青霉素类的广谱抗生素，主要抑制革兰氏阴性菌，特别是各种肠杆菌。此外，Amdinocillin对多种β-内酰胺酶具有抗性，不易被降解。 | |||
| M46680 | ChemBridge-8896721 | ChemBridge化合物-8896721 | Screening Compounds and Building Blocks |
| 2-(6-fluoro-1H-indol-3-yl)-N-(5-methylisoxazol-3-yl)-2-oxoacetamide (8896721) | |||
| ChemBridge特有类药化合物/先导化合物-8896721，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M47264 | ChemBridge-10649315 | ChemBridge化合物-10649315 | Screening Compounds and Building Blocks |
| 4-[1-(4-methoxyphenyl)-1H-pyrazol-4-yl]-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]-2-pyrimidinamine trifluoroacetate (10649315) | |||
| ChemBridge特有类药化合物/先导化合物-10649315，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M47273 | ChemBridge-10989939 | ChemBridge化合物-10989939 | Screening Compounds and Building Blocks |
| 1-[2-(2,3-dihydro-1H-inden-1-yl)ethyl]-3-piperidinol trifluoroacetate (salt) (10989939) | |||
| ChemBridge特有类药化合物/先导化合物-10989939，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M47523 | ChemBridge-20189851 | ChemBridge化合物-20189851 | Screening Compounds and Building Blocks |
| rel-(2R,3R)-3-{methyl[3-(3-methylphenoxy)propyl]amino}-2,3-dihydrospiro[indene-1,4'-piperidin]-2-ol bis(trifluoroacetate) (salt) (20189851) | |||
| ChemBridge特有类药化合物/先导化合物-20189851，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M47533 | ChemBridge-20459631 | ChemBridge化合物-20459631 | Screening Compounds and Building Blocks |
| ({1-[1-(4'-methyl-4-biphenylyl)-4-piperidinyl]-3-pyrrolidinyl}methyl)amine bis(trifluoroacetate) (20459631) | |||
| ChemBridge特有类药化合物/先导化合物-20459631，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M47738 | ChemBridge-28570051 | ChemBridge化合物-28570051 | Screening Compounds and Building Blocks |
| 1-{[1-(4-fluorophenyl)cyclopropyl]methyl}-3-piperidinol trifluoroacetate (salt) (28570051) | |||
| ChemBridge特有类药化合物/先导化合物-28570051，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M48051 | ChemBridge-41117699 | ChemBridge化合物-41117699 | Screening Compounds and Building Blocks |
| N-[1-(3-pyridinylmethyl)-4-piperidinyl]-4-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2-pyrimidinamine bis(trifluoroacetate) (41117699) | |||
| ChemBridge特有类药化合物/先导化合物-41117699，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M48058 | ChemBridge-41669980 | ChemBridge化合物-41669980 | Screening Compounds and Building Blocks |
| 1-{[1-(2-fluorophenyl)cyclopropyl]methyl}-4-piperidinol trifluoroacetate (salt) (41669980) | |||
| ChemBridge特有类药化合物/先导化合物-41669980，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M48560 | ChemBridge-62317277 | ChemBridge化合物-62317277 | Screening Compounds and Building Blocks |
| N-[4-(1,3-dimethyl-1H-pyrazol-4-yl)-2-pyrimidinyl]-N'-methyl-1,2-ethanediamine trifluoroacetate (62317277) | |||
| ChemBridge特有类药化合物/先导化合物-62317277，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M48936 | ChemBridge-80121052 | ChemBridge化合物-80121052 | Screening Compounds and Building Blocks |
| 5-fluoro-2-{1-[4-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2-pyrimidinyl]-4-piperidinyl}-1H-benzimidazole bis(trifluoroacetate) (80121052) | |||
| ChemBridge特有类药化合物/先导化合物-80121052，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M48947 | ChemBridge-80692514 | ChemBridge化合物-80692514 | Screening Compounds and Building Blocks |
| rel-(2R,3R)-3-[(3-methoxypropyl)(methyl)amino]-2,3-dihydrospiro[indene-1,4'-piperidin]-2-ol bis(trifluoroacetate) (salt) (80692514) | |||
| ChemBridge特有类药化合物/先导化合物-80692514，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M49163 | ChemBridge-91147939 | ChemBridge化合物-91147939 | Screening Compounds and Building Blocks |
| 2-(4-{[[2-(1H-imidazol-1-yl)ethyl](methyl)amino]methyl}phenyl)-6-(3-pyridinyl)-4(3H)-pyrimidinone bis(trifluoroacetate) (91147939) | |||
| ChemBridge特有类药化合物/先导化合物-91147939，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M49281 | ChemBridge-96221706 | ChemBridge化合物-96221706 | Screening Compounds and Building Blocks |
| 5-{[4-(phenoxyacetyl)-1-piperazinyl]carbonyl}-1,3-benzothiazol-2-amine trifluoroacetate (96221706) | |||
| ChemBridge特有类药化合物/先导化合物-96221706，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M49294 | ChemBridge-97310819 | ChemBridge化合物-97310819 | Screening Compounds and Building Blocks |
| 1-{4-[2-methyl-6-(4-morpholinyl)-4-pyrimidinyl]-1-piperidinyl}-1-oxoacetone (97310819) | |||
| ChemBridge特有类药化合物/先导化合物-97310819，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M49366
|
Boc-Glycine | BOC-甘氨酸 | Others |
| N-tert-Butoxycarbonyl-2-aminoacetic acid; NSC 127669 | |||
| Boc-Glycine是一种甘氨酸衍生物，可用于多肽的合成。 | |||
| M49986 | ChemBridge-18184934 | ChemBridge化合物-18184934 | Screening Compounds and Building Blocks |
| N-({5-[4-(2-aminoethyl)benzyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl}methyl)-2-pyrimidinamine bis(trifluoroacetate) (18184934) | |||
| ChemBridge特有类药化合物/先导化合物-18184934，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M50055 | ChemBridge-60813478 | ChemBridge化合物-60813478 | Screening Compounds and Building Blocks |
| 6-(aminomethyl)-2-(3-{[methyl(3-phenoxypropyl)amino]methyl}phenyl)-4(3H)-pyrimidinone bis(trifluoroacetate) (60813478) | |||
| ChemBridge特有类药化合物/先导化合物-60813478，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M51913 | (S)-2-(2-Aminoacetamido)-3-(1H-imidazol-4-yl)propanoic acid | (S)-2-(2-Aminoacetamido)-3-(1H-imidazol-4-yl)propanoic acid | Amino Acid Derivatives |
| (S)-2-(2-Aminoacetamido)-3-(1H-imidazol-4-yl)propanoic acid 是一种组氨酸衍生物。 | |||
| M51934 | (S)-2-(2-(2-Aminoacetamido)acetamido)-3-(1H-imidazol-4-yl)propanoic acid | (S)-2-(2-(2-Aminoacetamido)acetamido)-3-(1H-imidazol-4-yl)propanoic acid | Amino Acid Derivatives |
| (S)-2-(2-(2-Aminoacetamido)acetamido)-3-(1H-imidazol-4-yl)propanoic acid 是一种组氨酸衍生物。 | |||
| M2788
|
JZL184 | JZL184 | MAGL |
| JZL184是第一个选择性的Monoacylglycerol lipase (MAGL)（单酰基甘油脂肪酶）抑制剂，IC50为8 nM。JZL184还可调控Amidase家族中的FAAH-4，具有极好的选择性。 | |||
| M3179
|
9-Aminoacridine | 9-氨基吖啶 | HIV Protease |
| Aminacrine | |||
| 9-Aminoacridine（9-氨基吖啶）是一种荧光探针，它可以用作细胞内pH指示剂，通过其荧光强度的变化来定量测定跨膜pH梯度，特别是酸性内部环境的pH值。9-Aminoacridine还具有抗菌活性和HIV-1抑制活性，以及用作利福平的佐剂。 | |||
| M3631
|
AZ505 ditrifluoroacetate | AZ505 ditrifluoroacetate | Histone Methyltransferase |
| AZ 505 ditrifluoroacetate; AZ-505 ditrifluoroacetate | |||
| AZ505 ditrifluoroacetate 是一种强效、高选择性的致癌蛋白SMYD2抑制剂(IC50=0.12 uM)，具有潜在的抗癌活性。 | |||
| M6177
|
SGC2085 | SGC2085 | PRMTs |
| SGC2085是一种有效的、选择性的Coactivator Associated Arginine Methyltransferase 1 (CARM1)抑制剂，IC50为50 nM，比对其他PRMTs的选择性高100倍以上。 | |||
| M6505
|
BIBO 3304 trifluoroacetate | BIBO 3304 trifluoroacetate | Neuropeptide Receptor |
| BIBO 3304 trifluoroacetate（BIBO 3304三氟乙酸酯）是一种精氨酸酰胺衍生物，同时也是选择性的，高亲和力的NPY Y1受体拮抗剂，作用于人类和大鼠的Y1受体上时，IC50值分别为0.38±0.06 nM和0.72±0.42 nM，具有抗焦虑活性。 | |||
| M6748
|
GGTI 298 Trifluoroacetate | GGTI 298 Trifluoroacetate | Ras |
| GGTI298 TFA | |||
| GGTI 298 Trifluoroacetate 是一种有效的 GGTase I 抑制剂，抑制 Rap1A 的 IC50 值为3μM。 | |||
| M9094
|
EG00229 Trifluoroacetate salt | EG00229 Trifluoroacetate salt | VEGFR/PDGFR |
| EG-00229 Trifluoroacetate | |||
| EG00229 Trifluoroacetate能抑制neuropilin-1与VEGFA的相互作用，能抑制125I-VEGF与PAE/NRP1细胞的结合，IC50为8 uM。 | |||
| M9468
|
SR-18292 | SR-18292 | PPAR |
| SR18292 | |||
| SR-18292是一种PPAR gamma coactivator-1α (PGC-1α)的抑制剂，它可以促进PGC-1α乙酰化，抑制糖异生基因的表达。 | |||
| M10652
|
Voacamine | 老刺木胺 | Cannabinoid |
| Voacamine is an indole alkaloid, exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells. | |||
| M11039 | Pyrazoloacridine | Pyrazoloacridine | Topoisomerase |
| NSC 366140 | |||
| Pyrazoloacridine (NSC 366140) 具有抗癌活性，抑制拓扑异构酶 1 和 2 的活性 (topoisomerases 1 and 2)。Pyrazoloacridine (NSC 366140) 对 K562 髓系白血病细胞中的 IC50 值为 1.25 μM (24 h)。 | |||
| M13343
|
Trichloroacetic acid | 三氯乙酸 | Metabolite/Endogenous Metabolite |
| Trichloroacetic acid 来源于三氯乙烯(TCE)代谢，可用作酸脱钙剂。Trichloroacetic acid 是三氯乙烯的代谢产物，它们具有致癌性并促进B6C3F1小鼠的肝肿瘤。 | |||
| M13938
|
ALX 40-4C Trifluoroacetate | ALX 40-4C Trifluoroacetate | CXCR |
| ALX 40-4C Trifluoroacetate 是一种趋化因子受体 (CXCR4) 抑制剂，能够抑制 SDF-1 与 CXCR4 结合，Ki 值为 1 μM，具有抗 HIV-1 作用；ALX 40-4C Trifluoroacetate 同时为 APJ 受体拮抗剂，IC50 值为 2.9 μM。 | |||
| M14064 | Pasireotide ditrifluoroacetate | 帕瑞肽二三氟乙酸盐 | Others |
| SOM230 ditrifluoroacetate; Pasireotide TFA salt | |||
| Pasireotide (SOM230) ditrifluoroacetate 是一种长效的环己肽生长激素抑制素类似物，同时也是大环类化合物，可以提高生长抑素受体(SSTR)的激动剂活性，对 sst1/2/3/4/5 的 pKi 分别为 8.2/9.0/9.1/<7.0/9.9。Pasireotide ditrifluoroacetate 具有抗分泌、抗增殖和促凋亡活性。 | |||
| M14208 | Endovion | Endovion | Chloride Channel |
| NS3728 | |||
| Endovion (NS3728) 是一种阴离子通道抑制剂 (如氯离子通道)，也是特异性的 VRAC/VSOAC 阻断剂。Endovion (NS3728) 还是一种 ANO1 抑制剂。 | |||
| M14232 | Rapastinel Trifluoroacetate | Rapastinel Trifluoroacetate | GluR |
| GLYX-13 Trifluoroacetate | |||
| Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) 是一种具有甘氨酸位点部分激动剂性质的 NMDA 受体调节剂。Rapastinel Trifluoroacetate 有潜力用于抑郁症的研究 | |||
| M14522 | Pepstatin Trifluoroacetate | 抑肽素三氟醋酸盐 | Proteasome |
| Pepstatin A Trifluoroacetate | |||
| Pepstatin Trifluoroacetate (Pepstatin A Trifluoroacetate) 是由放线菌类产生的一种特异性的天冬氨酸蛋白酶 (aspartic proteases) 抑制剂，能够抑制 hemoglobin-pepsin，hemoglobin-proctase，casein-pepsin，casein-proctase，casein-acid protease 和 hemoglobin-acid protease 的活性，IC50 值分别为 4.5 nM，6.2 nM，150 nM，290 nM，520 nM 和 260 nM。 | |||
| M20458 | Tabersonine hydrochloride | Tabersonine hydrochloride | Amyloid |
| Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1?42) aggregation and toxicity. | |||
| M20483 | 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride | 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride | Reverse Transcriptase |
| 4-Chloro-2-(trifluoroacetyl)aniline hydrochloride is a HIV-1 RT (HIV reverse transcriptase) inhibitor. | |||
| M20718 | Tubastatin A TFA | Tubastatin A TFA | HDAC |
| Tubastatin A trifluoroacetate salt | |||
| Tubastatin A TFA (Tubastatin A trifluoroacetate salt) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). Tubastatin A promotes autophagy and increases apoptosis. | |||
| M21203
|
Recombinant Human/Mouse/Rat Irisin (HEK293, C-6His) | 重组人/小鼠/大鼠Irisin蛋白 (HEK293, C-6His) | Cytokines and Growth Factors |
| Fibronectin type III domain-containing protein 5 | |||
| Fibronectin type III domain-containing protein 5 is the precursor of irisin. Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts. | |||
| M21204
|
Recombinant Human/Mouse/Rat Irisin (HEK293, C-Fc) | 重组人/小鼠/大鼠Irisin蛋白 (HEK293, C-Fc) | Cytokines and Growth Factors |
| Fibronectin type III domain-containing protein 5 | |||
| Fibronectin type III domain-containing protein 5 is the precursor of irisin. Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts. | |||
| M21205
|
Recombinant Human/Mouse/Rat Irisin (HEK293, N-6His) | 重组人/小鼠/大鼠Irisin 蛋白(HEK293, N-6His) | Cytokines and Growth Factors |
| Fibronectin type III domain-containing protein 5 | |||
| Fibronectin type III domain-containing protein 5 is the precursor of irisin. Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts. | |||
| M30211
|
Voacangine | Voacangine | TRP Channel |
| Voacangine是 TRPV1 和 TRPM8 的拮抗剂，但也是 TRPA1 的激动剂 (EC50=8 μM)。Voacangine 竞争性抑制薄荷醇与 TRPM8 的结合(IC50=9 μM)，对 icilin 表现出非竞争性抑制 (IC50=7 μM)。Voacangine 选择性地消除化学激动剂诱导的 TRPM8 激活，而不影响冷诱导的激活。Voacangine 是从美洲山梨 Voacanga africana 的根皮中分离得到的生物碱。 | |||
| M30647 | Mechercharmycin A | Mechercharmycin A | Apoptosis |
| Mechercharmycin A 是一种从海洋来源的 Thermoactinomyces sp. YM3-251 分离出的细胞毒性物质。Mechercharmycin A 具有较强的抗肿瘤活性。 | |||
| M55314
|
Recombinant Mouse Decorin Protein (HEK293, C-6His) | 重组小鼠Decorin 蛋白 (HEK293, C-6His) | Cytokines and Growth Factors |
| DCN | |||
| Decorin (DCN) is a secreted chondroitin/dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). Decorin regulates assembly of the extracellular collagen matrix and the bioactivity of the matrix associated growth factors such as FGF2, GDF8/Myostatin, TGFβ and WISP1. It also binds and activates EGFR, ErbB4 and IGFI-R. | |||
| M54475 | Small Cardioactive Peptide B (SCPB) | Small Cardioactive Peptide B (SCPB) | Adenylate Cyclase |
| Small Cardioactive Peptide B (SCPB) 是一种神经活性肽，刺激心脏和鳃组织的颗粒组分中的腺苷酸环化酶 (adenylate cyclase) 活性，EC50 分别为 0.1 和 1.0 μM。 | |||
| M55024
|
Recombinant Human DPP4/CD26 (HEK293, C-6His) | 重组人DPP4/CD26 (HEK293, C-6His) | Cytokines and Growth Factors |
| Dipeptidyl Peptidase 4; DPP IV; ADCP-2 | |||
| DPP4/CD26 is a signal-anchor for type II membrane protein that belongs to the peptidase S9B family. DPP4/CD26 acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. It’s binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. | |||
