找到约 54 条 “IBR2” 相关结果 （用时 0.198 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M1676
|
BIBR1532 | BIBR1532 | Checkpoint |
| BIBR-1532 | |||
| BIBR 1532是一种有效的，选择性的，非竞争性的端粒酶 telomerase 抑制剂，IC50为100 nM，也可通过抑制ATM/CHK1（ataxia-telangiectasia-mutated/Checkpoint kinase 1）通路发挥作用。BIBR1532 也是TERT抑制剂，TERT是端粒酶活性调节的限速酶。 | |||
M1825
|
PCI-32765 | 伊布替尼；依鲁替尼 | BTK |
| Ibrutinib; CRA-032765 | |||
| Ibrutinib (PCI-32765)是一种有效的，高选择性的，不可逆的Btk抑制剂，IC50为0.5 nM，作用于Bmx， CSK， FGR， BRK及HCK，适度有效，对EGFR， Yes， ErbB2， JAK3等作用效果稍弱。可用于慢性淋巴细胞白血病（CLL）的相关研究。 | |||
| M3289
|
Telmisartan | 替米沙坦 | Angiotensin Receptor |
| BIBR 277 | |||
| Telmisartan是一种血管紧张素II受体的拮抗剂，IC50 值为 9.2 nM。常用于高血压的相关研究。Telmisartan通过选择性阻断血管紧张素II（Angiotensin II）与其受体AT1R的结合，抑制血管紧张素II介导的血管收缩作用，从而降低外周血管阻力，达到降压效果。在动物模型中，Telmisartan还对PPARγ具有一定的激动作用，能够改善糖脂代谢，具有抗炎和心血管保护效果。 | |||
| M8784
|
NIBR-0213 | NIBR-0213 | S1P Receptor |
| NIBR-0213是一种口服活性、强效和s1p1选择性鞘氨醇1-磷酸(S1P)受体拮抗剂。 | |||
| M9371
|
Recombinant Human Fibronectin (HEK293) | 重组人纤维连接蛋白（HEK293） | Cytokines and Growth Factors |
| 重组人纤维连接蛋白（Recombinant Human Fibronectin）由574个氨基酸组成，可以显著增强逆转录病毒介导的基因转移到哺乳动物细胞。本名为液体型式。 | |||
| M11108
|
Recombinant Human FGF-basic (145aa, E. coli) | 重组人FGF basic/bFGF蛋白 (145aa, E. coli) | Cytokines and Growth Factors |
| Fibroblast Growth Factor-basic; FGF-2 | |||
| 重组人FGF basic/bFGF 蛋白 (145aa, E. coli) 也称为 FGF-2，是一种多效细胞因子，是肝素结合 FGF 家族的原型成员之一。 | |||
| M11496
|
FGF-basic, Rat (E. coli) | FGF-basic, Rat (E. coli) | Cytokines and Growth Factors |
| Fibroblast Growth Factor-basic; FGF-2; BFGF; FGFB; HBGF-2; bFGF; Prostatropin | |||
| FGF-basic, Rat（E. coli） 蛋白构造：Expressed with an N-terminal Gly.FGF-basic (Pro10-Ser154) Accession # P13109。 生物活性：ED50 < 0.25 ng/ml，采用3T3细胞增殖法测定，对应> 4.0 × 106单位/mg。 | |||
| M11624 | ChemBridge-5113023 | ChemBridge化合物-5113023 | Screening Compounds and Building Blocks |
| N'-(3,5-dibromo-2-hydroxybenzylidene)-4-nitrobenzohydrazide (5113023) | |||
| ChemBridge特有类药化合物/先导化合物-5113023，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11700 | ChemBridge-5141951 | ChemBridge化合物-5141951 | Screening Compounds and Building Blocks |
| potassium 4-{[4-(allyloxy)-3,5-dibromophenyl]sulfonyl}-2,6-dibromobenzenolate (5141951) | |||
| ChemBridge特有类药化合物/先导化合物-5141951，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11702 | ChemBridge-5142855 | ChemBridge化合物-5142855 | Screening Compounds and Building Blocks |
| disodium 4,4'-sulfonylbis(2,6-dibromobenzenolate) (5142855) | |||
| ChemBridge特有类药化合物/先导化合物-5142855，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11856 | ChemBridge-5225755 | ChemBridge化合物-5225755 | Screening Compounds and Building Blocks |
| 5,7-dibromo-1H-indole-2,3-dione 3-oxime (5225755) | |||
| ChemBridge特有类药化合物/先导化合物-5225755，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11862 | ChemBridge-5228270 | ChemBridge化合物-5228270 | Screening Compounds and Building Blocks |
| N-(3,5-dibromo-4-hydroxyphenyl)-4-methylbenzenesulfonamide (5228270) | |||
| ChemBridge特有类药化合物/先导化合物-5228270，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11882 | ChemBridge-5234242 | ChemBridge化合物-5234242 | Screening Compounds and Building Blocks |
| 2,4-dibromo-6-{[(2-chlorobenzoyl)amino]methyl}phenyl 2-nitrobenzoate (5234242) | |||
| ChemBridge特有类药化合物/先导化合物-5234242，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11883 | ChemBridge-5234250 | ChemBridge化合物-5234250 | Screening Compounds and Building Blocks |
| 2,4-dibromo-6-{[(2-chlorobenzoyl)amino]methyl}phenyl 4-fluorobenzoate (5234250) | |||
| ChemBridge特有类药化合物/先导化合物-5234250，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11884 | ChemBridge-5234251 | ChemBridge化合物-5234251 | Screening Compounds and Building Blocks |
| 2,4-dibromo-6-{[(2-chlorobenzoyl)amino]methyl}phenyl 2-methylbenzoate (5234251) | |||
| ChemBridge特有类药化合物/先导化合物-5234251，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11890 | ChemBridge-5236849 | ChemBridge化合物-5236849 | Screening Compounds and Building Blocks |
| 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(dimethylamino)-2-propanol (5236849) | |||
| ChemBridge特有类药化合物/先导化合物-5236849，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11891 | ChemBridge-5236896 | ChemBridge化合物-5236896 | Screening Compounds and Building Blocks |
| 1-anilino-3-(3,6-dibromo-9H-carbazol-9-yl)-2-propanol (5236896) | |||
| ChemBridge特有类药化合物/先导化合物-5236896，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11909 | ChemBridge-5248896 | ChemBridge化合物-5248896 | Screening Compounds and Building Blocks |
| 4-[1-(benzylamino)ethylidene]-2-(2,4-dibromophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one (5248896) | |||
| ChemBridge特有类药化合物/先导化合物-5248896，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11955 | ChemBridge-5279218 | ChemBridge化合物-5279218 | Screening Compounds and Building Blocks |
| 3,5-dibromo-N'-(2-furylmethylene)-2-hydroxybenzohydrazide (5279218) | |||
| ChemBridge特有类药化合物/先导化合物-5279218，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M12260 | ChemBridge-5673258 | ChemBridge化合物-5673258 | Screening Compounds and Building Blocks |
| 3-(3,6-dibromo-9H-carbazol-9-yl)propanoic acid (5673258) | |||
| ChemBridge特有类药化合物/先导化合物-5673258，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M13438
|
Recombinant Mouse FGF-basic (E. coli) | 重组小鼠bFGF蛋白 (E. coli) | Cytokines and Growth Factors |
| Fibroblast Growth Factor-basic; FGF-2; FGFB | |||
| 碱性成纤维细胞生长因子(FGF-2; FGF-basic)，也被称为HBGF-2，是一种非糖基化肝素结合生长因子，属于FGF家族。 | |||
| M13725
|
IBR2 | IBR2 | RAD51 |
| IBR2 是一种有效且特异性的 RAD51 抑制剂，可抑制 RAD51 介导的 DNA 双链断裂修复。IBR2 破坏 RAD51 的多聚化，加速蛋白酶体介导的 RAD51 蛋白质降解，抑制癌细胞的生长并诱导细胞凋亡 (apoptosis)。 | |||
| M15030
|
Recombinant Human FGF-21 (E. coli) | 重组人FGF-21蛋白 (E. coli) | Cytokines and Growth Factors |
| FGF21; fibroblast growth factor-21; FGFL | |||
| 成纤维细胞生长因子-21 (FGF-21)是一种代谢细胞因子，属于肝素结合FGF家族。蛋白构造：Expressed with an N-terminal Gly，FGF-21 (His29-Ser209)，Accession # Q9NSA1。 | |||
| M15066
|
Recombinant Human FGF-basic (146 aa, E.coli) | 重组人FGF-basic蛋白 (146 aa, E.coli) | Cytokines and Growth Factors |
| Fibroblast growth factor 2; FGF-2; bFGF | |||
| FGF-basic is a members of the Fibroblast Growth Factors (FGFs) family. FGF-basic acts on several cell types to regulate diverse physiologic functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, neurotrophic effects, and tissue repair. | |||
| M31133
|
Recombinant Mouse FGF-10/KGF-2 Protein (E. coli) | 重组小鼠FGF-10/KGF-2蛋白 (E. coli) | Cytokines and Growth Factors |
| Fibroblast Growth Factor-10; FGFA; Keratinocyte growth factor-2 | |||
| Fibroblast Growth Factor-10 (FGF-10, also known as KGF-2) is a mitogen mainly produced by mesenchymal stem cells in lung. FGF-10 is an essential factor for the budding and branching morphogenesis during multi-organ development via mesenchymal-epithelial interactions. | |||
| M46977 | ChemBridge-9148553 | ChemBridge化合物-9148553 | Screening Compounds and Building Blocks |
| 2,5-dibromo-N-(2-methoxyethyl)benzenesulfonamide (9148553) | |||
| ChemBridge特有类药化合物/先导化合物-9148553，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M49883 | Nickel,dibromo[1,2-ethanediylbis[diphenylphosphine-kP]]-, (SP-4-2)- (9CI) | Nickel,dibromo[1,2-ethanediylbis[diphenylphosphine-kP]]-, (SP-4-2)- (9CI) | Others |
| Nickel,dibromo[1,2-ethanediylbis[diphenylphosphine-kP]]-, (SP-4-2)- (9CI) | |||
| M51345 | Fibronectin Type III Connecting Segment Fragment 1-25 | Fibronectin Type III Connecting Segment Fragment 1-25 | Others |
| Fibronectin Type III Connecting Segment Fragment 1-25 是一种负责黑色素瘤细胞粘附的多肽，在鸡周围神经系统的发育中发挥着重要作用。 | |||
| M53940 | Brain Derived Basic Fibroblast Growth Factor (1-24) | Brain Derived Basic Fibroblast Growth Factor (1-24) | Antibiotic |
| Brain Derived Basic Fibroblast Growth Factor (1-24) (FGF basic 1-24) 是一种合成肽，表现出抗细菌和抗 HBV 的活性。 | |||
| M54765
|
2,3-Dibromomaleinimide | 2,3-二溴马来酰亚胺 | Others |
| 3,4-Dibromo-1H-pyrrole-2,5-dione | |||
| 2,3-Dibromomaleinimide (3,4-Dibromopyrrole-2,5-dione) 是一种海洋来源的天然产物，存在于Axinella brevistyla。 | |||
| M2529
|
Clofibric Acid (PCIB) | 氯贝酸；2-(对-氯苯氧基)-异丁酸；降固醇酸 | PPAR |
| 2-(4-Chlorophenoxy)-2-methylpropionic acid; Chlorofibrinic acid | |||
| Clofibric acid (2-(对-氯苯氧基)-异丁酸)，一种脂质纤维调节剂 Clofibrate，Etofibrate 和 Etofyllinclofibrate 活性代谢物，是 PPARα 的激动剂，具有降血脂作用。Clofibric acid 也是一种生长素信号转导的抑制剂。 | |||
| M55399
|
Recombinant Rat FGF-basic (E. coli, Ala11-Ser154) | 重组大鼠FGF-basic (E. coli, Ala11-Ser154) | Cytokines and Growth Factors |
| FGF-2; Fibroblast Growth Factor-basic; FGFb; bFGF | |||
| Fibroblast Growth Factor-basic (FGF-basic), also known as FGF-2, is a pleiotropic cytokine and one of the prototypic members of the heparin-binding FGF family. FGF-basic regulates a variety of processes including cell proliferation, differentiation, survival, adhesion, motility, apoptosis, limb formation and wound healing. FGF-basic is a non-glycosylated heparin binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland liver, monocytes, epithelial cells and endothelial cells. | |||
| M3897
|
Ferulic Acid | 阿魏酸 | FGFR |
| Coniferic acid | |||
| Ferulic acid 是一种新型的 fibroblast growth factor receptor (FGFR) 抑制剂，对FGFR1和FGFR2的IC50分别为3.78 μM和12.5 μM，是在Ferula assafoetida L或Ligusticum chuanxiong中发现的一种有机化合物。 | |||
| M6141
|
NIBR189 | NIBR189 | GPR/FFAR |
| NIBR189是一个EBI2（GPR183）小分子拮抗剂，IC50值为11nM。 | |||
| M6723
|
Fenofibrate | 非诺贝特 | PPAR |
| Fenofibrate 是一种选择性的 PPARα 激动剂，EC50 为 30 μM。Fenofibrate 抑制细胞色素 P450 亚型, 对 CYP2C19，CYP2B6，CYP2C9，CYP2C8 和 CYP3A4 的 IC50 分别为 0.2，0.7，9.7，4.8 和 142.1 μM。 | |||
| M7822
|
Gemfibrozil | 吉非罗齐 | PPAR |
| 吉非罗齐; CI-719 | |||
| Gemfibrozil 是一种 PPAR-α 激活剂，同时是 P450 的非选择性抑制剂，对 CYP2C9，2C19，2C8 和 1A2 的 Ki 值分别为 5.8，24，69 和 82 μM。 | |||
| M8743 | FPMINT | FPMINT | Others |
| FPMINT is a potent, irreversible and non-competitive inhibitor of equilibrative nucleoside transporters ENT1 and ENT2. | |||
| M8809 | Trandolapril | 群多普利 | Others |
| RU44570 | |||
| Studies have reported that trandolapril inhibits atherosclerosis1 and decreases the occurrence of atrial fibrillation2. | |||
| M10500
|
Remibrutinib | 瑞布替尼 | BTK |
| LOU064 | |||
| Remibrutinib (LOU064)是一款潜在同类最佳（best-in-class）的，具有口服活性的，有效的BTK共价抑制剂，IC50 值为 1 nM，在血液中抑制 BTK 活性的 IC50 的值为 0.23 μM。可用于慢性荨麻疹 (CU) 的相关研究。 | |||
| M13504
|
Epibrassinolide | 表油菜素内酯 | Plant growth regulators |
| 24-Epibrassinolide; B1105; BP55 | |||
| Epibrassinolide (24-Epibrassinolide) 是一种广泛存在的植物生长激素，具有缓解植物重金属和农药胁迫潜力。Epibrassinolide (24-Epibrassinolide) 在各种癌细胞中是一种潜在的凋亡（apoptosis）诱导剂，而不影响非肿瘤细胞生长。 | |||
| M13825 | Molibresib besylate | Molibresib besylate | Epigenetic Reader Domain |
| GSK 525762C; I-BET 762 besylate | |||
| Molibresib besylate (GSK 525762C; I-BET 762 besylate) 是 BET 溴结构域抑制剂，IC50 为32.5-42.5 nM。 | |||
| M14882 | Ibrutinib-biotin | 依鲁替尼-生物素 | BTK |
| Ibrutinib-biotin 是一种由 Ibrutinib 通过长链接头连接到生物素上组成的探针，具体可参考 WO2014059368A1 中 Compound 1-5，抑制 BTK，IC50 值为 0.755-1.02 nM。 | |||
| M18090 | 2,4-Dibromo-5-hydroxybenzaldehyde | 2,4-二溴-5-羟基苯甲醛 | Others |
| 2,4-Dibromo-5-hydroxybenzaldehyde 2,4-二溴-5-羟基苯甲醛 | |||
| M19895
|
Doxycycline | 多西环素；强力霉素 | Antibiotic |
| Vibramycin; Doxytetracycline; Doxiciclina; Doxycyclinum | |||
| Doxycycline(Vibramycin，多西环素，强力霉素)是一种具有口服活性的，有效的，合成的，广谱的四环素类抗生素，对革兰阳性菌和革兰阴性菌都有抑制作用，能通过与30S和50S核糖体亚单位结合，从而阻断氨酰基tRNA与mRNA-核糖体复合物的结合，导致蛋白质合成的抑制。此外，Doxycycline还能诱导转录因子的单个或组合转基因（transgene）生成hESC：即GATA6和SOX17，将hESC变为下胚层样细胞；GATA3和TFAP2C，将hESC变为滋养层样细胞。具有抗菌和抗原虫活性。 | |||
| M20792 | Bromfenac sodium hydrate | Bromfenac sodium hydrate | COX |
| Bromsite, Bromday, Prolensa, Xibrom | |||
| Bromfenac sodium hydrate (Bromsite, Bromday, Prolensa, Xibrom), a brominated nonsteroidal anti-inflammatory drugs (NSAID) with strong in vitro anti-inflammatory potency, is a potent and orally active inhibitor of COX with IC50 of 5.56 nM and 7.45 nM for COX-1 and COX-2, respectively. | |||
| M20983 | Barnidipine | Barnidipine | Calcium Channel |
| Libradin, Mepirodipine, Vasexten, YM-09730-5, Cyress, Hypoca, Oldeca | |||
| Barnidipine (Libradin, Mepirodipine, Vasexten, YM-09730-5, Cyress, Hypoca, Oldeca) is an antihypertensive drug that belongs to the dihydropyridine (DHP) group of calcium antagonist (CaA) with Ki of 0.21 nM for [3H]nitrendipine binding sites. | |||
| M24898 | Ibritumomab tiuxetan | 替伊莫单抗 | CD20 |
| Ibritumomab tiuxetan 是一种免疫偶联物，由与螯合剂 Tiuxetan 共价结合的鼠 IgG1κ 抗 CD20 单克隆抗体 Ibritumomab 组成。Ibritumomab tiuxetan 可以与放射性同位素结合，用于非霍奇金 B 细胞淋巴瘤的研究。 | |||
| M25591 | ChemBridge-Fragment Library | ChemBridge-化合物片段库 | Screening Libraries |
ChemBridge为全球科学家提供超过15000个高品质化合物片段库，适用于基于片段化合物的筛选、高通量X-ray 晶体学、NMR、SPR和高浓度生物分析。Fragment Library中所有化合物均符合Rule of Three原则（MW ≤ 300, H-bond donors ≤ 3, H-bond acceptors ≤ 3, cLogP ≤ 3，RB ≤ 3) 和TPSA ≤ 120），同时符合ChemBridge独有的多样性要求和物化特性筛选原则。 AbMole是ChemBridge在中国地区唯一官方指定合作伙伴。 |
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| M25601 | ChemBridge-Nuclear Receptor Library | ChemBridge-核受体化合物库 | Screening Libraries |
ChemBridge的NHRCore Library由超过2000个新型类药化合物组成。这些化合物与已公布的靶向核受体的抑制剂/激动剂具有相似的3D药效团指纹，拥有超过250个全新骨架。被认定为Hit的化合物均有现货的类似物。 AbMole是ChemBridge在中国地区唯一官方指定合作伙伴。 |
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| M25602 | ChemBridge-Kinase Library | ChemBridge-激酶化合物库 | Screening Libraries |
ChemBridge的KINACore Library由经计算机挑选出的超20000个类药化合物组成，这些化合物具有与已公布的靶向激酶的活性化合物相似的3D药效团指纹或由ATP的腺苷部分产生的匹配的药效团。对广泛的激酶谱具有潜在活性。拥有超420个全新骨架。被认定为Hit的化合物均有现货的类似物。 AbMole是ChemBridge在中国地区唯一官方指定合作伙伴。 |
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| M25604 | ChemBridge-Ion Channel Library | ChemBridge-离子通道化合物库 | Screening Libraries |
ChemBridge的Ion Channel Library由经计算机挑选出的超6000个类药化合物组成，这些化合物具有与已公布的靶向离子通道的活性化合物相似的3D药效团指纹。对多种离子通道具有潜在活性。拥有超320个全新骨架。被认定为Hit的化合物均有现货的类似物。 AbMole是ChemBridge在中国地区唯一官方指定合作伙伴。 |
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| M43045 | Tibric acid | Tibric acid | Others |
| Tibric Acid (CP 18524) 与降血脂药具有相似的作用。 | |||
| M43869
|
Recombinant Human Integrin alpha V beta 3 Protein (HEK293, C-His) | 重组人Integrin alpha V beta 3 蛋白 (HEK293, C-His) | Cytokines and Growth Factors |
| ITGAV/ITGB3 | |||
| Integrin alpha-V & beta-3 (ITGAV/ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. | |||
| M45353 | Dibromo-dodecenyl-methylsulfimide | Dibromo-dodecenyl-methylsulfimide | Cytochrome P450 (e.g. CYP17) |
| DDMS | |||
| Dibromo-dodecenyl-methylsulfimide是一种选择性的20-HETE合成抑制剂，并可减弱硝普钠 (SNP) 的血管舒张反应。 | |||
