找到约 30 条 “Chloride Channel” 相关结果 （用时 0.128 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M2406
|
Articaine hydrochloride | 盐酸阿替卡因 | Animal experimental anesthetics |
| Ultracaine | |||
| Articaine hydrochloride（Ultracaine，盐酸阿替卡因）是一种酰胺类局部麻醉剂，通过结合特定的膜钠离子通道（Sodium Channel），能可逆地阻断神经冲动的传导，从而干扰神经中的电兴奋，减缓神经冲动的传播并降低动作电位的上升速率。Articaine hydrochloride 通过抑制 NF-ĸB 的激活和 NLRP3 炎症小体通路改善脂多糖 (LPS) 诱导的急性肾损伤。 | |||
| M2810
|
Levobupivacaine hydrochloride | 盐酸左布比卡因 | Animal experimental anesthetics |
| (S)-(-)-Bupivacaine monohydrochloride | |||
| Levobupivacaine HCl 是一种长效的酰胺类局部麻醉剂。Levobupivacaine hydrochloride 通过可逆性阻断神经元钠通道 (sodium channel) 发挥麻醉镇痛作用。 | |||
| M2989
|
Ropivacaine hydrochloride monohydrate | 盐酸罗哌卡因一水合物 | Animal experimental anesthetics |
| Ropivacaine hydrochloride monohydrate是一种有效的钠离子通道 (sodium channel) 阻断剂，通过可逆地抑制钠离子流入来阻断神经纤维上冲动的传导。Ropivacaine 是一种长效酰胺类局麻剂，可用于神经性疼痛的缓解的相关研究。 | |||
| M3118
|
Verapamil hydrochloride | 盐酸维拉帕米 | Calcium Channel |
| (±)-Verapamil hydrochlorid; CP-16533-1 hydrochloride | |||
| Verapamil hydrochloride是一种具有口服活性的L-型钙通道（Calcium Channel）抑制剂，可以消除钙通道激动剂诱导的钙内流和细胞凋亡。Verapamil hydrochloride 也是一种有效的口服活性的第一代 P 糖蛋白 (P-gp) 抑制剂。维拉帕米能抑制 CAT1 介导的精氨酸、高精氨酸和 ADMA 的吸收，其 IC50 值分别为 85.3、58.1 和 113 µM。 | |||
| M3358
|
Procainamide hydrochloride | 盐酸普鲁卡因胺 | Sodium Channel |
| Procaine amide hydrochloride; SP 100 hydrochloride | |||
| Procainamide hydrochloride是一种sodium channel的阻断剂，也是DNA甲基转移酶抑制剂。 | |||
| M3500
|
Diltiazem hydrochloride | 盐酸地尔硫卓；地尔硫；硫氮卓酮；恬尔心； | Calcium Channel |
| CRD-401 | |||
| Diltiazem hydrochloride（地尔硫，硫氮卓酮，恬尔心，酸地尔硫卓）是一种钙通道（Calcium Channel）阻滞剂，对细胞外钙离子的跨膜流入具有抑制作用，可用于肿瘤及心血管疾病的相关研究。 | |||
| M4240
|
Shikonin | 紫草素 | TNF Receptor |
| C.I. 75535; Isoarnebin 4; CAS# 54952-43-1 | |||
| Shikonin (C.I. 75535, Isoarnebin 4, 紫草素) 是中药紫草的主要成分，同时也是一种有效的，特异的Pyruvate kinase M2 (PKM2)抑制剂。Shikonin 也是一种有效的 TMEM16A 氯化物通道 (chloride channel) 抑制剂，IC50 为 6.5 μM。可通过抑制 TNF-α 发挥抗炎作用，并可通过抑制 proteasome 来阻止NF-κB信号途径的激活，具有多种生物活性。 | |||
| M4886
|
Selamectin | 塞拉菌素；司拉克丁 | Parasite |
| Selamectin是一种抗寄生虫剂和驱虫剂，能激活神经元和咽肌中的谷氨酸门控氯离子通道 (glutamate-gated chloride channels)，以预防恶丝虫、淋巴丝虫和线虫感染。Selamectin 还是一种有效的 P-糖蛋白 (P-glycoprotein) 底物和抑制剂，IC50 为 120 nM。 | |||
| M6431 | AM 92016 hydrochloride | AM 92016 hydrochloride | Others |
| AM 92016 hydrochloride is a k V channel blocker. | |||
| M6499
|
Bepridil hydrochloride | 盐酸贝普地尔 | Calcium Channel |
| CERM 1978 | |||
| Bepridil hydrochloride (CERM 1978) 是一种钙离子通道 (calcium channel) 抑制剂，可以用于心绞痛的研究。 | |||
| M6580
|
Cesium chloride | 氯化铯 | Potassium Channel |
| Cesium chloride is a potassium channel blocker; neuroprotective. | |||
| M6755
|
GMQ hydrochloride | 1-(4-甲基喹唑啉-2-基)胍盐酸盐 | Sodium Channel |
| GMQ hydrochloride is a potent and selective modulator of acid-sensing ion channel (ASIC) that activates ASIC3 channels under neutral pH. GQM blocks acid-induced maximal peak current and alters ASICs pH dependence for activation and inactivation. | |||
| M6913 | LOE 908 hydrochloride | LOE 908 hydrochloride | Others |
| LOE 908 hydrochloride is a broad spectrum cation channel blocker; neuroprotective. | |||
| M7010 | N20C hydrochloride | N20C hydrochloride | Others |
| N20C hydrochloride is a non-competitive NMDA receptor open-channel blocker. | |||
| M7034
|
NNC 55-0396 dihydrochloride | NNC 55-0396 dihydrochloride | Calcium Channel |
| NNC 55-0396 dihydrochloride is a highly selective Ca 2+ channel blocker (T-type). | |||
M7041
|
NPPB | NPPB | Chloride Channel |
| Hoechst 144; HOE 144 | |||
| NPPB（Hoechst 144; HOE 144）是一种非特异性氯离子通道（chloride channel）阻滞剂，IC50 为 80 nM。同时能以可逆的，剂量依赖性的方式阻断IK(Ca)电流，在HL-60和GL-15细胞中的IC(50)为39 μM和125 μM。此外，NPPB还能减少AFB细胞的迁移，其IC50值为53.09 μM。 | |||
| M7053 | NS 8593 hydrochloride | NS 8593 hydrochloride | Others |
| NS 8593 hydrochloride is a selective K Ca2 (SK) channel negative modulator; inhibits SK currents. | |||
| M7149 | PNU 37883 hydrochloride | PNU 37883 hydrochloride | Others |
| PNU 37883 hydrochloride is a vascular K ir6 (K ATP) channel blocker. | |||
| M7177
|
Quinine hydrochloride | 金鸡纳碱单盐酸盐 | Potassium Channel |
| Quinine hydrochloride（金鸡纳碱单盐酸盐）是一种从金鸡纳树皮中提取的生物碱Quinine的盐酸盐形式，具有抗疟和抗肿瘤活性，作用于恶性疟原虫passou和3CD7株的IC50值分别是60 ng/mL和107.8 ng/mL。同时，Quinine hydrochloride 也是一种钾离子通道 (potassium channel) 抑制剂，可抑制电压脉冲引起的 MT mSlo3 (KCa5.1) 通道 +100 mV 电流, 其 IC50 值为 169 μM。此外，Quinine hydrochloride还能以低纳摩尔亲和力与嘌呤核苷磷酸化酶（PfPNP）结合。 | |||
| M7188 | Remacemide hydrochloride | Remacemide hydrochloride | Others |
| Remacemide hydrochloride is a nMDA antagonist; blocks ion channel and allosteric modulatory site. | |||
| M7303
|
SKF 96365 hydrochloride | SKF 96365 hydrochloride | TRP Channel |
| SKF-96365 hydrochloride 是一种有效的 TRP channel 阻滞剂和 SOCE (store-operated Ca2+ entry) 抑制剂。还能诱导结直肠癌细胞的细胞周期阻滞和凋亡 (apoptosis) 。 | |||
| M7494 | XE 991 dihydrochloride | XE 991 dihydrochloride | Others |
| XE 991 dihydrochloride is a potent, selective K V7 (KCNQ) channel blocker; blocks M-currents. | |||
| M7605 | Aprindine hydrochloride | 盐酸茚丙胺 | Others |
| Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. | |||
| M7794 | Encainide hydrochloride | 恩卡尼盐酸盐 | Others |
| Encainide hydrochloride is a sodium channel blocker and class Ic antiarrhythmic. | |||
| M7884 | Lidocaine N-ethyl chloride | Lidocaine N-ethyl chloride | Others |
| Lidocaine N-ethyl chloride is an intracellular voltage-gated sodium channel blocker. | |||
| M7892 | Lidocaine hydrochloride monohydrate | 盐酸利多卡因一水合物 | Animal experimental anesthetics |
| Lidocaine hydrochloride monohydrate is an Na+ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration. | |||
| M8025 | Protopine hydrochloride | 盐酸原阿片碱；盐酸前鸦片碱；盐酸普罗托平/蓝堇碱 | Others |
| Protopine hydrochloride is a Ca2+ channel blocker and antiplatelet agent. | |||
| M8793 | Tocainide hydrochloride | Tocainide hydrochloride | Others |
| Tocainide hydrochloride is a sodium channel blocker; Class IB antiarrhythmic. | |||
| M10200
|
Chlorotoxin | 氯毒素 | Chloride Channel |
| Chlorotoxin是一个由36个氨基酸组成的肽段，具有抗癌活性；也是一种氯离子通道 (chloride channel) 阻断剂。 | |||
| M10624
|
Tetraethylammonium chloride | 四乙基氯化铵 | Potassium Channel |
| TEACl | |||
| Tetraethylammonium chloride 是一种非选择性的钾通道 (potassium channel) 阻滞剂。 | |||
