找到约 35 条 “XT-1” 相关结果 （用时 0.108 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
| M11040 | AMXT-1501 tetrahydrochloride | AMXT-1501 tetrahydrochloride | Apoptosis |
| AMXT-1501 tetrahydrochloride 是一种具有口服活性的多胺转运系统 (polyamine transport) 抑制剂。AMXT-1501 可阻断免疫活性小鼠中的肿瘤生长，但不能阻断缺乏 T 细胞无胸腺裸鼠中的肿瘤生长。DFMO 和 AMXT-1501 联合诱导 caspase-3 介导的 NB 细胞凋亡。 | |||
| M11628 | ChemBridge-5113723 | ChemBridge化合物-5113723 | Screening Compounds and Building Blocks |
| N'-(4-bromobenzylidene)-2-(1-naphthyl)acetohydrazide (5113723) | |||
| ChemBridge特有类药化合物/先导化合物-5113723，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11808 | ChemBridge-5210410 | ChemBridge化合物-5210410 | Screening Compounds and Building Blocks |
| 3,5-di-tert-butyl-N-1-naphthylbenzamide (5210410) | |||
| ChemBridge特有类药化合物/先导化合物-5210410，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11816 | ChemBridge-5211072 | ChemBridge化合物-5211072 | Screening Compounds and Building Blocks |
| 3-{[(4-bromophenyl)amino]sulfonyl}-N-(3-nitrophenyl)benzamide (5211072) | |||
| ChemBridge特有类药化合物/先导化合物-5211072，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11917 | ChemBridge-5253067 | ChemBridge化合物-5253067 | Screening Compounds and Building Blocks |
| N-(3-methylphenyl)-4-biphenylsulfonamide (5253067) | |||
| ChemBridge特有类药化合物/先导化合物-5253067，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
M21464
|
FITC-Dextran (MW 10000) | 荧光素异硫氰酸酯-葡聚糖 | Fluorescent Dye |
| FITC-Dextran (MW 10000，荧光素异硫氰酸酯-葡聚糖) 是一种异硫氰酸荧光素 (FITC) 葡聚糖荧光探针 (Ex=495 nm; Em=525 nm)。FITC-Dextran (MW 10000) 可作为一种标记物来揭示热休克引起的细胞损伤，并研究细胞凋亡的早期和晚期阶段。FITC-Dextran (MW 10000) 还可用于细胞渗透性的研究，如血脑屏障通透性以及血脑屏障破坏程度的测定。 | |||
| M25540
|
Dextran (Mw 150000) | 葡聚糖 (分子量 150000) | Others |
| Dextran 葡聚糖是一种多用途的支链葡聚糖，可提高血浆胶体渗透压，增加血容量，减低血小板黏附性并抑制红细胞凝聚，降低血液黏稠度，降低周围循环阻力，疏通微循环。 | |||
| M29627
|
Gersizangitide acetate | Gersizangitide acetate | Peptides |
| AXT-107 acetate | |||
| Gersizangitide acetate(AXT-107 acetate) 是一种血管生成抑制剂。 | |||
| M43975
|
Dextran T-10 | 葡聚糖T-10；右旋糖酐 | Others |
| Dextran D10 | |||
| Dextran T-10 是一种多用途的支链葡聚糖，可提高血浆胶体渗透压，增加血容量，减低血小板黏附性，抑制红细胞凝聚，降低血液黏稠度，降低周围循环阻力以及疏通微循环。 | |||
| M53545 | XT-1 | XT-1 | Antibiotic |
| XT-1 是一种来源于热带爪蟾 Xenopus tropicalis 皮肤分泌物中的抗菌肽。 | |||
| M1849
|
Voxtalisib (XL765) | 伏他西布 | PI3K |
| SAR245409 | |||
| Voxtalisib (SAR245409, XL765)是作用于mTOR/PI3K的双重抑制剂，对p110γ作用最强，IC50为9 nM；也可抑制DNA-PK和mTOR。 | |||
| M2878
|
Nexturastat A | Nexturastat A | HDAC |
| Nexturastat A 是一种高度选择性HDAC抑制剂，IC50 为5 nM,其选择性高于其他的HDACs190倍。 | |||
M4974
|
GW4869 2HCl | 外泌体合成/释放抑制剂 | Phospholipase |
| GW69A; GW554869A | |||
| GW4869是一种外泌体（Exosomes）和胞外囊泡(Extracellular vesicles)的合成及释放的抑制剂。GW4869 也是一种非竞争性的N-Smase（中性鞘磷脂酶）抑制剂，IC50为1 μM。GW4869广泛用于外泌体功能和肿瘤研究等领域。 | |||
| M10396
|
Deruxtecan | Deruxtecan | Drug-Linker Conjugates for ADC |
| Deruxtecan是一种细胞毒性分子和linker的偶联物，由DX-8951 的衍生物（DXd）和马来酰亚胺-GGFG 肽偶联而成。Deruxtecan 可用于合成 DS-8201 和 U3-1402。 | |||
| M11286 | NXT629 | NXT629 | PPAR |
| NXT629 是一种有效、选择性、竞争性的 PPAR-α 拮抗剂，对人 PPARα 的 IC50 值为 77 nM，对其选择性高于对其他核激素受体，比如 PPARδ，PPARγ，Erβ，GR 和 TRβ，IC50 值分别为 6.0，15，15.2，32.5 和 >100 μM。 | |||
| M20458 | Tabersonine hydrochloride | Tabersonine hydrochloride | Amyloid |
| Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1?42) aggregation and toxicity. | |||
| M20694 | Bay 41-4109 racemate | Bay 41-4109 racemate | Anti-infection |
| BAY41-4109 Racemic | |||
| BAY 41-4109 racemate is a mixture of R-isomer of BAY 41-4109 and S-isomer of BAY 41-4109. BAY 41-4109 an antiviral compound that inhibits human hepatitis B virus (HBV) with IC50 of 53 nM. | |||
| M20780 | CC-90010 | CC-90010 | Epigenetic Reader Domain |
| CC-90010 is a reversible, orally active and central nervous system-penetrant inhibitor of bromodomain and extra-terminal (BET) proteins. CC-90010 is applied in the study for advanced solid tumors. | |||
| M20868 | Phytic acid dipotassium salt | Phytic acid dipotassium salt | Gamma-secretase/Beta-secretase |
| Phytic acid potassium, IP6 (PS) | |||
| Phytic acid dipotassium salt (Phytic acid potassium, IP6 (PS)), an endogenous metabolite in rice grain extract and digest, inhibits β-secretase 1 (BACE1) with IC50 of approximately 0.25 μM. | |||
| M20983 | Barnidipine | Barnidipine | Calcium Channel |
| Libradin, Mepirodipine, Vasexten, YM-09730-5, Cyress, Hypoca, Oldeca | |||
| Barnidipine (Libradin, Mepirodipine, Vasexten, YM-09730-5, Cyress, Hypoca, Oldeca) is an antihypertensive drug that belongs to the dihydropyridine (DHP) group of calcium antagonist (CaA) with Ki of 0.21 nM for [3H]nitrendipine binding sites. | |||
| M21331
|
Recombinant Human CDH1 (HEK293, C-6His) | 重组人CDH1 蛋白 (HEK293, C-6His) | Cytokines and Growth Factors |
| Cadherin-1; CDH1;CAM 120/80;E-cadherin; CD324 | |||
| Recombinant human Cadherin-1/E-Cadherin/CDH1 is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. Accession: P12830. | |||
| M24828
|
Trastuzumab deruxtecan | 德曲妥珠单抗 | Drug-Linker Conjugates for ADC |
| DS-8201; DS-8201a; T-DXd | |||
| Trastuzumab deruxtecan (DS-8201a) 是一种抗人表皮生长因子受体 2 (HER2) 抗体-药物偶联物 (ADC)。Trastuzumab deruxtecan 由人源化抗 HER2 抗体，酶促裂解的肽接头和拓扑异构酶 I 抑制剂组成。Trastuzumab deruxtecan 可用于 HER2 阳性乳腺癌和胃癌的研究。 | |||
| M25010 | Patritumab deruxtecan | Patritumab deruxtecan | Drug-Linker Conjugates for ADC |
| HER3-DXd; U3-1287; U3-1402 | |||
| Patritumab deruxtecan (HER3-DXd) 是一种抗体-药物偶联物 (ADC)，由全人抗 HER3 IgG1ҡ 单克隆抗体 Patritumab 偶联DXd/DX-8951 而成，DXd/DX-8951 是一种拓扑异构酶 I 抑制剂载荷，通过稳定的基于GGFG的可降解连接子连接。 | |||
| M29717 | XT2 | XT2 | Others |
| XT2 是一种有效的、具有口服活性的、选择性的 NF-κB 诱导激酶 (NIK) 抑制剂，IC50 为 9.1 nM。XT2 抑制 CCl4 诱导的 ALT 上调，ALT 是急性肝损伤的关键生物标志物。XT2 还可以减少免疫细胞向受损肝组织的浸润。XT2具有研究肝脏炎症性疾病的潜力。 | |||
| M30147 | TC OT 39 | TC OT 39 | Oxytocin Receptor |
| TC OT 39 是一种合成的催产素类似物，也是催产素受体 (oxytocin receptor) 的选择性激动剂 (OXTR，EC50=180 nM)。TC OT 39 也是 Avprla 加压素受体拮抗剂，Ki 值为 330 nM。TC OT 39 在小鼠模型中表现出镇静的作用。 | |||
| M30979 | Dextromilnacipran | 左旋米那普仑 | Serotonin Transporter |
| (1R,2S)-milnacipran; F2696; Levomilnacipran | |||
| Dextromilnacipran (F2696; (1R,2S)-milnacipran) 是米那普仑的对映体，是一种选择性 5- 羟色胺和去甲肾上腺素 (5-HT/NE) 再摄取抑制剂，可用于抑郁的相关研究。Dextromilnacipran 也是一种人类 α 肾上腺素能受体拮抗剂，IC50 为 3.4 μM。 | |||
| M55314
|
Recombinant Mouse Decorin Protein (HEK293, C-6His) | 重组小鼠Decorin 蛋白 (HEK293, C-6His) | Cytokines and Growth Factors |
| DCN | |||
| Decorin (DCN) is a secreted chondroitin/dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). Decorin regulates assembly of the extracellular collagen matrix and the bioactivity of the matrix associated growth factors such as FGF2, GDF8/Myostatin, TGFβ and WISP1. It also binds and activates EGFR, ErbB4 and IGFI-R. | |||
| M40765
|
Datopotamab deruxtecan | 德达博妥单抗 | Others |
| Dato-DXd | |||
| Datopotamab deruxtecan是一种由人源化、靶向人滋养层细胞表面糖蛋白抗原2（Trop2）的 IgG1 单克隆抗体与创新DNA拓扑异构酶I抑制剂（DXd）通过稳定的四肽可裂解连接子偶联而成的抗体偶联药物（ADC），药物/抗体比率（DAR）值为4，可用于非小细胞肺癌（NSCLC）的相关研究。 | |||
| M41896 | Firazorexton hydrate | Firazorexton hydrate | OX Receptor |
| Firazorexton hydrate (TAK-994) 是一种有效的食欲素 2 型受体 (OX2R) 激动剂 (EC50: 19 nM)。 | |||
| M43917
|
Recombinant Human Thrombospondin-1 Protein (E. coli, N-His) | 重组人Thrombospondin-1 蛋白 (E. coli, N-His) | Cytokines and Growth Factors |
| THBS1; TSP1 | |||
| Thrombospondin-1 (THBS1; TSP1) regulates a wide range of cellular functions including their interactions with other cells and with the extracellular matrix (ECM). TSP-1 counteracts the angiogenic, hypotensive, and antithrombotic effects of nitric oxide (NO). It binds and neutralizes VEGF, blocks VEGF R2 signaling on vascular endothelial cells(EC), and destabilizes adhesive contacts between EC. | |||
| M54431 | Gersizangitide | Gersizangitide | Others |
| Gersizangitide (AXT-107) 是一种血管生成抑制剂。 | |||
| M55312
|
Recombinant Human Decorin Protein (HEK293, C-6His) | 重组人Decorin 蛋白 (HEK293, C-6His) | Cytokines and Growth Factors |
| DCN | |||
| Decorin (DCN) is a secreted chondroitin/dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). Decorin regulates assembly of the extracellular collagen matrix and the bioactivity of the matrix associated growth factors such as FGF2, GDF8/Myostatin, TGFβ and WISP1. It also binds and activates EGFR, ErbB4 and IGFI-R. | |||
| M55313
|
Recombinant Human Decorin Protein (HEK293) | 重组人Decorin 蛋白 (HEK293) | Cytokines and Growth Factors |
| DCN | |||
| Decorin (DCN) is a secreted chondroitin/dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). Decorin regulates assembly of the extracellular collagen matrix and the bioactivity of the matrix associated growth factors such as FGF2, GDF8/Myostatin, TGFβ and WISP1. It also binds and activates EGFR, ErbB4 and IGFI-R. | |||
| M55353
|
Recombinant Human BMP-9 Protein (E. coli, His Tag) | 重组人BMP-9 蛋白 (E. coli, His Tag) | Cytokines and Growth Factors |
| Bone Morphogenetic Protein-9; GDF-2 | |||
| Bone Morphogenetic Protein-9 (BMP-9), also known as Growth differentiation factor 2 (GDF2), is an extracellular multifunctional cytokine that is also a member of the TGF-β family. BMP-9/GDF-2 selectively signals through ACVRL1 in endothelial cells. Additionally, it engages in high-affinity interactions with ENG, forming a heterotetramer or a heteromeric complex with ENG and ACVRL1. | |||
| M58204
|
Cross-linked dextran G-25 | 葡聚糖凝胶G-25 | Others |
| Cross-linked dextran G-25 (同Sephadex G-25) 是一种由葡聚糖交联而制得的凝胶，具有立体多孔的网状结构。主要用于糖、多糖、氨基糖、肽类、蛋白质、酶的水溶液分离。也用于更高分子量及水不溶物质的分离。Cross-linked dextran G 25 分离范围为 1-5 kD (球形蛋白)，可用于多肽的分离以及大分子蛋白质的脱盐和缓冲液替换。中颗粒，粒径50-150μm | |||
