找到约 54 条 “Pyr3” 相关结果 （用时 0.036 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M3876
|
6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile | 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile | Others |
| 6-溴-4-甲氧基吡唑并[1,5-A]吡啶-3-甲腈 | |||
| M3877
|
4-Chloro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine | 4-Chloro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine | Others |
| 4-Chloro-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine | |||
| M54751
|
2-Hydroxymethyl-5-hydroxypyridine | 2-Hydroxymethyl-5-hydroxypyridine | Others |
| 6-(Hydroxymethyl)pyridin-3-ol | |||
| 2-Hydroxymethyl-5-hydroxypyridine 是从 S. lychnophora 的成熟和干燥种子中分离出来的。 | |||
| M4424
|
Tetramethylpyrazine (2,3,5,6-Tetramethylpyrazine) | 川芎嗪 | Apoptosis |
| Chuanxiongzine; Tetramethylpyrazine；Ligustrazine | |||
| Tetramethylpyrazine (2,3,5,6-Tetramethylpyrazine) 是从Ligusticum wallichii (Chuan Xiong)中提取的一种烷基吡嗪，常在薯条、面包、茶、乳制品、豆制品等食物中作为香精。Ligustrazine 对大鼠具有潜在的抗神经和抗炎活性。 | |||
| M5043
|
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine | 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine | Others |
| 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine是一种重要的医药中间体，在国内外广泛用于许多医药中间体的合成。包括CP690550、CGP76030等，同时也是许多市售药物的支架。此外，4-Chloro-7H-pyrrolo[2,3-d]pyrimidine也是Tofatinib原料药的中间体。 | |||
| M8479 | Pyr6 | Pyr6 | Others |
| N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide | |||
| Pyr6 is a selective inhibitor of calcium release from the endoplasmic reticulum via STIM1/Orai1 mediated, store operated calcium entry (SOCE). | |||
M8978
|
3-TYP | 3-TYP | Sirtuin |
| 3-(1H-1,2,3-triazol-4-yl) pyridine; 3TYP | |||
| 3-TYP是一种选择性的SIRT（Sirtuin）3抑制剂，比对 SIRT1 和 SIRT2 的选择性强，3-TYP对SIRT1、SIRT2、SIRT3的IC50值分别为88 nM、92 nM和16 nM。 | |||
| M9034
|
Mitapivat (AG-348) | 米他匹瓦 | Pyruvate Kinase |
| PKR-IN-1; PKM2 activator 1020; Pyrukynd； AG-348 | |||
| Mitapivat（AG-348）是一款首创的（first-in-class），口服活性的，丙酮酸激酶同工酶R（PKR）的变构激活剂。Mitapivat（AG-348）针对野生型和各种突变PKR酶均具有活性，通过激活基因突变的PKR增加ATP水平，促进健康血红细胞生成。可用于溶血性贫血，以及红细胞丙酮酸激酶缺乏症的相关研究。 | |||
| M9180
|
Pyridostatin Trifluoroacetate Salt | Pyridostatin Trifluoroacetate Salt | DNA/RNA Synthesis |
| Pyridostatin TFA salt; PDS; CAS# 1085412-37-8(free base) | |||
| Pyridostatin Trifluoroacetate Salt是一种G-quadruplexe稳定剂，无细胞试验中Kd为490 nM。Pyridostatin Trifluoroacetate Salt可以促进DNA双链断裂(DSB)的形成。 | |||
| M9668 | 6-chloropyrido[3,2-d]pyrimidine-2,4-diamine | 6-chloropyrido[3,2-d]pyrimidine-2,4-diamine | Others |
| 6-chloropyrido[3,2-d]pyrimidine-2,4-diamine | |||
| M9672 | 5-Chloropyridazine-3,4-diamine | 5-氯哒嗪-3,4-二胺 | Others |
| 5-Chloropyridazine-3,4-diamine | |||
| M9680
|
3-Bromopyruvate (3-Bromopyruvic acid) | 3-溴丙酮酸 | Others |
| Hexokinase II Inhibitor II; 3-BP | |||
| 3-Bromopyruvate (3-Bromopyruvic acid)是hexokinase II (己糖激酶II) 抑制剂，是一种有效的针对肝癌细胞的抗肿瘤剂，Ki 为 2.4 mM，可抑制糖酵解/己糖激酶。它是肿瘤细胞能量代谢的抑制剂和铂类的化学增强剂。 | |||
| M10197
|
(Glp1)-Apelin-13 human, bovine | 人,牛(GLP1)-APELIN-13肽；[PYR1]-爱帕琳肽-13 | Apelin Receptor |
| [Pyr1]-Apelin-13 | |||
| (Glp1)-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist. | |||
| M11558 | ChemBridge-4001635 | ChemBridge化合物-4001635 | Screening Compounds and Building Blocks |
| 4-(1H-pyrazol-5-yl)aniline (4001635) | |||
| ChemBridge特有类药化合物/先导化合物-4001635，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11559 | ChemBridge-4003557 | ChemBridge化合物-4003557 | Screening Compounds and Building Blocks |
| 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylic acid (4003557) | |||
| ChemBridge特有类药化合物/先导化合物-4003557，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11566 | ChemBridge-4011498 | ChemBridge化合物-4011498 | Screening Compounds and Building Blocks |
| 5-(4-aminophenyl)-2,4-dihydro-3H-pyrazol-3-one (4011498) | |||
| ChemBridge特有类药化合物/先导化合物-4011498，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11571 | ChemBridge-4015344 | ChemBridge化合物-4015344 | Screening Compounds and Building Blocks |
| 4-methyl-3-(2-thienyl)-1H-pyrazol-5-amine hydrochloride (4015344) | |||
| ChemBridge特有类药化合物/先导化合物-4015344，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11574 | ChemBridge-4027450 | ChemBridge化合物-4027450 | Screening Compounds and Building Blocks |
| 4-(1-pyrrolidinyl)-1,3,5-triazin-2-amine (4027450) | |||
| ChemBridge特有类药化合物/先导化合物-4027450，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11576 | ChemBridge-4035752 | ChemBridge化合物-4035752 | Screening Compounds and Building Blocks |
| 2-(4-morpholinyl)-5-pyrimidinecarboxylic acid (4035752) | |||
| ChemBridge特有类药化合物/先导化合物-4035752，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11597 | ChemBridge-5104073 | ChemBridge化合物-5104073 | Screening Compounds and Building Blocks |
| 4-{2-[(1,2-dihydro-5-acenaphthylenylmethyl)thio]ethyl}-1-[2-(1,2-dihydro-5-acenaphthylenyl)-2-oxoethyl]pyridinium bromide (5104073) | |||
| ChemBridge特有类药化合物/先导化合物-5104073，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11620 | ChemBridge-5110223 | ChemBridge化合物-5110223 | Screening Compounds and Building Blocks |
| (5-bromo-3-pyridinyl)(4-methylphenyl)methanone (5110223) | |||
| ChemBridge特有类药化合物/先导化合物-5110223，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11621 | ChemBridge-5112759 | ChemBridge化合物-5112759 | Screening Compounds and Building Blocks |
| 1-(2-furylmethylene)-6-methyl-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-one (5112759) | |||
| ChemBridge特有类药化合物/先导化合物-5112759，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11627 | ChemBridge-5113462 | ChemBridge化合物-5113462 | Screening Compounds and Building Blocks |
| 4-hydroxy-3-methoxybenzaldehyde 5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-ylhydrazone (5113462) | |||
| ChemBridge特有类药化合物/先导化合物-5113462，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11631 | ChemBridge-5115555 | ChemBridge化合物-5115555 | Screening Compounds and Building Blocks |
| 8-[4-(dimethylamino)benzylidene]-4-[4-(dimethylamino)phenyl]-6-propyl-3,4,5,6,7,8-hexahydropyrido[4,3-d]pyrimidine-2(1H)-thione (5115555) | |||
| ChemBridge特有类药化合物/先导化合物-5115555，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11642 | ChemBridge-5118322 | ChemBridge化合物-5118322 | Screening Compounds and Building Blocks |
| 4-(3,4-dimethoxyphenyl)-1H-pyrazol-5-amine (5118322) | |||
| ChemBridge特有类药化合物/先导化合物-5118322，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11651 | ChemBridge-5122035 | ChemBridge化合物-5122035 | Screening Compounds and Building Blocks |
| 4-[(5-bromo-2-pyridinyl)amino]-4-oxobutanoic acid (5122035) | |||
| ChemBridge特有类药化合物/先导化合物-5122035，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11653 | ChemBridge-5123430 | ChemBridge化合物-5123430 | Screening Compounds and Building Blocks |
| 2-amino-1-phenyl-1H-pyrrolo[2,3-b]quinoxaline-3-carbonitrile (5123430) | |||
| ChemBridge特有类药化合物/先导化合物-5123430，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11661 | ChemBridge-5128773 | ChemBridge化合物-5128773 | Screening Compounds and Building Blocks |
| 3-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid (5128773) | |||
| ChemBridge特有类药化合物/先导化合物-5128773，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11668 | ChemBridge-5133193 | ChemBridge化合物-5133193 | Screening Compounds and Building Blocks |
| 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid (5133193) | |||
| ChemBridge特有类药化合物/先导化合物-5133193，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M11669 | ChemBridge-5133201 | ChemBridge化合物-5133201 | Screening Compounds and Building Blocks |
| 1-(3-nitrophenyl)-1H-pyrrole-2,5-dione (5133201) | |||
| ChemBridge特有类药化合物/先导化合物-5133201，由AbMole（奥默生物）独家提供。具体售价货期请咨询AbMole（奥默生物）。运费额外计算。 | |||
| M2760
|
Hydroxyzine dihydrochloride | 盐酸羟嗪 | Histamine Receptor |
| Hydroxyzine 2HCl抑制[3H]pyrilamine或[3H]desloratadine与人源组胺H1受体的结合， IC50分别为10 nM和19 nM。 | |||
| M43893 | Dihydro-1-[6-[4-(hydroxymethyl)-1-piperidinyl]-3-pyridinyl]-2,4(1H,3H)-pyrimidinedione | Dihydro-1-[6-[4-(hydroxymethyl)-1-piperidinyl]-3-pyridinyl]-2,4(1H,3H)-pyrimidinedione | Ligand for E3 Ligase |
| Dihydro-1-[6-[4-(hydroxymethyl)-1-piperidinyl]-3-pyridinyl]-2,4(1H,3H)-pyrimidinedione | |||
| M3737
|
Pyridone 6 | 吡啶酮6 | JAK |
| Merck-5, CMP 6, JAK Inhibitor I | |||
| Pyridone 6 (CMP 6) 是高活性的JAK抑制剂，对JAK1（小鼠），JAK2和Tyk2的IC50分别为15 nM，1 nM和1 nM，对JAK3的Ki为5 nM，对其它蛋白酪氨酸激酶的亲和性极低。 | |||
| M5351
|
Sulfinpyrazone | 磺吡酮；苯磺唑酮；磺吡拉宗 | COX |
| (+/-)-Sulfinpyrazone | |||
| Sulfinpyrazone是研究得最多的血小板COX抑制剂之一。Sulfinpyrazone (G-28315) 也是一种口服有效的尿酸剂 (uricosuric agent)。Sulfinpyrazone 具有抗血栓和血小板抑制作用。 | |||
| M6875
|
L-152,804 | L-152,804 | Neuropeptide Receptor |
| L-152804 | |||
| L-152,804（L-152804）是一种具有口服活性和脑渗透性的，有效的、选择性的非肽类Neuropeptide Y Receptor（NPYR）拮抗剂，Ki值为 26 nM，比作用于hY1、hY2和hY4受体的选择性高300倍。此外，L-152804还能通过调节食物摄入和能量消耗，减轻饮食诱导的肥胖小鼠的体重，可用于摄食，体重调节以及血糖的相关研究。 | |||
| M8083
|
MCC950 sodium salt (CP-456773) | MCC950 sodium salt (CP-456773) | Pyroptosis |
| CP-456773 sodium; CRID3 sodium salt | |||
| MCC950 (CP-456773) sodium salt 是一种有效的、选择性的NLRP3和细胞焦亡 (pyroptosis) 抑制剂，可在骨髓来源的巨噬细胞和人类单核细胞衍生的巨噬细胞中，抑制经典和非经典NLRP3激活，IC50分别为7.5 nM和8.1 nM。 | |||
| M8515 | Nifetepimine | Nifetepimine | Others |
| Nifetepimine is a dihydropyrimidone calcium channel blocker that down-modulates SERCA3 (sarco/endoplasmic reticulum Ca2+ -ATPase 3) pump, and protects of the CD4+ T cells from tumor-induced apoptosis. | |||
| M8578 | Undecylprodigiosin hydrochloride | Undecylprodigiosin hydrochloride | Others |
| Undecylprodigiosin is a tri-pyrolle antibiotic isolated from Streptomyces coelicolor A3 that exhibits immunosuppressive and apoptotic activities as well as antibacterial, antioxidative and UV protective properties. | |||
| M8772 | SAK3 | SAK3 | Others |
| SAK3 is a potent and orally active spiroimidazopyridine derivative that enhances Cav3. | |||
| M8803
|
Thiolutin | 硫藤黄素 | Others |
| Acetopyrrothin | |||
| Thiolutin (Acetopyrrothin) 是细菌和酵母 RNA 聚合酶的有效抑制剂。Thiolutin 抑制 JAB1/MPN/Mov34 (JAMM) 金属蛋白酶 Csn5, SHAM-Domain-of-STAM (AMSH) 相关的分子以及特异性去泛素酶 Brcc36。 | |||
| M9712
|
Pyrocatechuic acid | 2,3-二羟基苯甲酸 | Metabolite/Endogenous Metabolite |
| 2,3-Dihydroxybenzoic acid; Catecholcarboxylic acid; NSC 27435 | |||
| Pyrocatechuic acid (2,3-Dihydroxybenzoic acid) is a normal human benzoic acid metabolite found in plasma, and has increased levels after aspirin ingestion. | |||
| M11039 | Pyrazoloacridine | Pyrazoloacridine | Topoisomerase |
| NSC 366140 | |||
| Pyrazoloacridine (NSC 366140) 具有抗癌活性，抑制拓扑异构酶 1 和 2 的活性 (topoisomerases 1 and 2)。Pyrazoloacridine (NSC 366140) 对 K562 髓系白血病细胞中的 IC50 值为 1.25 μM (24 h)。 | |||
| M13784
|
Fluorescein di (β-D-galactopyranoside) | Fluorescein di (β-D-galactopyranoside) | Fluorescent Dye |
| FDG | |||
| Fluorescein di (β-D-galactopyranoside) 是 β-半乳糖苷酶的荧光底物 (λex=485 nm，λem=535 nm)。 | |||
| M14140
|
Pyrotinib dimaleate | Pyrotinib dimaleate | EGFR/HER2 |
| SHR-1258 dimaleate | |||
| Pyrotinib dimaleate (SHR-1258 dimaleate) 是有效、选择性的 EGFR/HER2 双重抑制剂，IC 50 值分别为 13 nM 和 38 nM。 | |||
| M14285
|
Pyr10 | Pyr10 | TRP Channel |
| Pyr10 是一种吡唑衍生物和一种选择性 TRPC3 通道抑制剂。Pyr10 抑制卡巴可刺激的 TRPC3 转染的 HEK293 细胞中的 Ca2+ 流入，IC50 为 0.72 μM (对于 BRL-2H3 细胞中存储的 Ca2+ 进入，IC50 为 13.08 μM)。Pyr10 具有区分受体操纵的 TRPC3 和天然基质相互作用分子 1 (STIM1)/Orai1 通道的能力。 | |||
| M14286 | Pyr3 | Pyr3 | TRP Channel |
| Pyr3 是 TRPC3 的选择性抑制剂，其对 TRPC3 介导的 Ca2+ 内流的 IC50 值为 700 nM。 | |||
| M17926 | 2-Naphthalenecarboxylic acid, 4-(D-glucopyranosyloxy)-1-hydroxy-3-(3-hydroxy-3-methylbutyl)-, methyl ester | 2-Naphthalenecarboxylic acid, 4-(D-glucopyranosyloxy)-1-hydroxy-3-(3-hydroxy-3-methylbutyl)-, methyl ester | Others |
| 2-Naphthalenecarboxylic acid, 4-(D-glucopyranosyloxy)-1-hydroxy-3-(3-hydroxy-3-methylbutyl)-, methyl ester 是一种天然产物，可以从 Rubia cordifolia 的根中提取得到。 | |||
| M17974 | Aloe-emodin-3-(hydroxymethyl)-O-β-D-glucopyranoside | 芦荟大黄素-3-（羟甲基）-O-β-D-葡萄糖苷 | Others |
| Aloe-emodin-3-(hydroxymethyl)-O-β-D-glucopyranoside (Aloe-emodin 3-O-β-D-glucoside) 是一种天然的蒽醌化合物。 | |||
| M18008 | (+)-Mediresinol Di-O-β-D-glucopyranoside | （+）-杜仲树脂酚双葡萄糖苷 | Others |
| (+)-Medioresinol Di-O-β-D-glucopyranoside 是一种木脂素葡糖苷，对3'，5'-环一磷酸 (环 AMP) 磷酸二酯酶具有很强的抑制活性。 | |||
| M18030 | Pomolic acid β-D-glucopyranosyl ester | 坡模酸-28-O-β-D-吡喃葡萄糖酯 | PAI-1 |
| 28-O-β-D-Glucopyranosyl pomolic acid 是尿激酶纤溶酶原激活物(uPA)抑制剂，IC50 为 37.82 μM。 | |||
| M18043 | Rubrofusarin-6-O-β-D-glucopyranoside | 红镰霉素-6-O-β-D-吡喃葡萄糖苷 | Phosphatase |
| Rubrofusarin 6-O-β-D-glucopyranoside 是 Rubrofusarin 的糖苷，是一种蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂，IC50 为 87.36 μM。 | |||
| M18151
|
Pyrroloquinoline quinone | 吡咯喹啉醌 | Metabolite/Endogenous Metabolite |
| PQQ; Methoxatin | |||
| Pyrroloquinoline quinone（PQQ）是一种水溶性醌类化合物，也是一种氧化还原酶的辅因子。 Pyrroloquinoline quinone具有较强的抗氧化作用，对自由基的清除活性是维生素C的6.3倍。 Pyrroloquinoline quinone还能够刺激线粒体，促进细胞快速生长。此外，它还能抑制脂肪酸合成，并促进脂肪酸的β氧化。 | |||
| M20460
|
3-Methylpyrazole | 3-Methylpyrazole | Dehydrogenase |
| 3-MP | |||
| 3-Methylpyrazole (3-MP) is a weak or non-inhibitor of alcohol dehydrogenase. | |||
| M20983 | Barnidipine | Barnidipine | Calcium Channel |
| Libradin, Mepirodipine, Vasexten, YM-09730-5, Cyress, Hypoca, Oldeca | |||
| Barnidipine (Libradin, Mepirodipine, Vasexten, YM-09730-5, Cyress, Hypoca, Oldeca) is an antihypertensive drug that belongs to the dihydropyridine (DHP) group of calcium antagonist (CaA) with Ki of 0.21 nM for [3H]nitrendipine binding sites. | |||
