找到约 25 条 “PAT-IN-2” 相关结果 （用时 0.106 秒）
| 目录号 | 产品名称 | 中文名称 | 靶点 |
|---|---|---|---|
M2819
|
Lomeguatrib | 罗米鲁曲 | DNA Methyltransferase |
| PaTrin-2 | |||
| Lomeguatrib是一种有效的O6-alkylguanine-DNA-alkyltransferase抑制剂，IC50为5 nM。 | |||
| M14935
|
YB-0158 | YB-0158 | Wnt/beta-catenin |
| Wnt pathway inhibitor 2 | |||
| YB-0158 (Wnt pathway inhibitor 2) 是一种反向转肽模拟物和一种有效的结直肠癌干细胞 (CSC) 靶向剂。YB-0158 破坏 Sam68-Src 相互作用并诱导结直肠癌细胞凋亡。YB-0158 具有抗癌活性。 | |||
| M41931 | PAT-IN-2 | PAT-IN-2 | Ras |
| PAT-IN-2 是一种蛋白质酰基转移酶 (PAT) 抑制剂。 | |||
| M53494 | Hepatitis Virus C NS3 Protease Inhibitor 2 | Hepatitis Virus C NS3 Protease Inhibitor 2 | HCV Protease |
| Hepatitis Virus C NS3 Protease Inhibitor 2 是基于产物的丙型肝炎病毒蛋白酶 ( HCV NS3 protease) 肽抑制剂，其 Ki 值为 41 nM。 | |||
M1802
|
Lapatinib ditosylate monohydrate | 二甲苯磺酸拉帕替尼一水合物 | EGFR/HER2 |
| GW572016 ditosylate monohydrate; GW2016 | |||
| Lapatinib (GW572016) ditosylate monohydrate 是一种有效的EGFR和ErbB2抑制剂，IC50分别为10.2 和 9.8 nM。 | |||
| M2990
|
Rupatadine Fumarate | 富马酸卢帕他定 | Histamine Receptor |
| Rupatadine Fumarate是一种PAFR和组胺(H1)受体抑制剂，Ki分别为550 nM和102 nM。 | |||
| M3517
|
Lapatinib | 拉帕替尼 | EGFR/HER2 |
| GW-572016; GW2016 | |||
| Lapatinib (GW572016) 是一种有效的EGFR和ErbB2抑制剂，IC50分别为10.2和9.8 nM。 | |||
| M4619
|
Eupalinolide B | 野马追内酯B | Others |
| Eupalinolide B 是从 Eupatorium lindleyanum 分离的胚芽倍半萜。 Eupalinolide B 对 A-549，BGC-823 和 HL-60 等肿瘤细胞具有细胞毒性。 | |||
| M4741
|
Harmine-hydrochloride | 哈尔碱盐酸盐 | DYRK |
| Harmine Hydrochloride (Telepathine Hydrochloride) 是一种具有抗癌和抗炎活性的 DYRK 抑制剂。Harmine Hydrochloride 对 5-HT2A 血清素受体具有高亲和力，Ki 值为 397 nM。 | |||
| M8709 | KIN1408 | KIN1408 | Others |
| KIN1408 is a small molecule that targets factors at or above the level of MAVS in the RLR signaling pathway to drive IRF3 activation (IRF3 nuclear translocation ECmax = 5 μM in 20 h; Huh7 cells) without significant cytotoxicity. | |||
| M11434
|
Enpatoran | Enpatoran | TLR |
| M5049 | |||
| Enpatoran (M5049) 是一款潜在“first-in-class”的口服活性的Toll样受体（TLR）7/8抑制剂，在HEK293 细胞中，其IC50s 分别为 11.1 nM 和 24.1 nM。 | |||
| M11452 | PAT-505 | PAT-505 | PDE |
| PAT-505 是一种有效，选择性的，非竞争性的可口服的 autotaxin 抑制剂，在 Hep3B 中，抑制 autotaxin 的活性，IC50 值为 2 nM，在人血液和小鼠血浆中，IC50 值分别为 9.7 nM 和 62 nM。 | |||
| M14137
|
Lapatinib ditosylate | 二甲苯磺酸拉帕替尼 | EGFR/HER2 |
| GW572016 ditosylate; GW2016 ditosylate | |||
| Lapatinib ditosylate (GW572016 ditosylate) 是一种 ErbB-2 和 EGFR 酪氨酸激酶结构域的有效抑制剂，对纯化的 EGFR 和 ErbB-2 的 IC50 值分别为 10.2 和 9.8 nM。 | |||
| M20734 | (E/Z)-BCI | (E/Z)-BCI | Phosphatase |
| BCI, NSC 150117 | |||
| (E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells. | |||
| M24595 | Patritumab | Patritumab | EGFR/HER2 |
| Human Anti-ERBB3 Recombinant Antibody | |||
| Patritumab (Human Anti-ERBB3 Recombinant Antibody) 是针对 ERBB3 的中和性单克隆抗体。Patritumab与 Cetuximab 具有协同作用，可有效抑制 EGFR，HER2，HER3，ERK 和 AKT 的磷酸化。Patritumab 也能诱导细胞凋亡 (apoptosis)，也抑制胰腺、非小细胞肺癌和结直肠癌异种移植物肿瘤的生长。 | |||
| M24634 | Luspatercept | 罗特西普 | TGF-beta/Smad |
| ACE-536; luspatercept-aamt | |||
| Luspatercept (ACE-536) 是一种首创的（first-in-class）重组修饰的 ActRIIB 融合蛋白，可与转化生长因子 β 超家族配体结合。Luspatercept 增加红细胞数量，促进红细胞前体成熟。Luspatercept 与 GDF11 结合，抑制 Smad2/3 信号通路。Luspatercept 可用于贫血以及骨髓增生异常综合征（MDS）的相关研究。 | |||
| M28134 | Sampatrilat | Sampatrilat | ACE |
| UK-81252 | |||
| Sampatrilat (UK-81252) 是一种强效具有口服活性的血管肽酶抑制剂，可抑制血管紧张素转换酶 (ACE) 和中性血管内肽酶 (NEP)。Sampatrilat 对 C-domain ACE (Ki=13.8 nM) 的抑制作用是 N-domain 的 12.4 倍 (Ki=171.9 nM)。Sampatrilat (UK-81252) 可用于慢性心力衰竭和血压调节的相关研究。 | |||
| M28635 | Rupatadine | 卢帕他定 | Histamine Receptor |
| UR-12592 | |||
| Rupatadine (UR-12592) 是一种有效的，具有口服活性的长效 PAF/H1 受体的双抑制剂，Ki 值分别为 0.55 μM 和 0.1 μM。Rupatadine 可用于过敏性鼻炎和荨麻疹的研究。 | |||
| M31128
|
Recombinant Mouse MMP-2 Protein (HEK293, N-His) | 重组小鼠MMP-2蛋白 (HEK293, N-His) | Enzymes & Regulators |
| Matrix Metalloproteinase-2 | |||
| Matrix Metalloproteinase-2 (MMP-2) is an enzyme that plays a pivotal role in cell migration during physiological and pathological processes. The recombinant mouse MMP-2 consists 273 amino acids and predicts a molecular mass of 30.9 kDa. | |||
| M38788 | Eupatoriopicrin | Eupatoriopicrin | Parasite |
| Eupatoriopicrin 是一种抗锥虫试剂，IC50 为 1.2 μM (T. b. rhodesiense)。Eupatoriopicrin 对 L6 细胞具有细胞毒性，IC50 为 1.6 μM。 | |||
| M40242 | 29-Nor-20-oxolupeol | 29-Nor-20-oxolupeol | Others |
| 29-Nor-20-oxolpeol，从 Impatiens basamina 中提取，降低了脂多糖激活的小鼠小胶质细胞中的 NO 水平，IC50 值为 44.21 μM。 | |||
| M53513 | Hepatitis B Virus Receptor Binding Fragment | Hepatitis B Virus Receptor Binding Fragment | Anti-infection |
| Hepatitis B Virus Receptor Binding Fragment (hepatitis B peptide 4980) 是一种合成的肽类似物，特异性地结合到 Hep G2 细胞。 | |||
| M55556
|
Recombinant Human IL-11 Protein (Yeast) | 重组人IL-11 (Yeast) | Cytokines and Growth Factors |
| Interleukin-11; Adipogenesis inhibitory factor; AGIF | |||
| Interleukin 11 (IL-11) is a member of a family of human growth factors that includes human growth hormone, granulocyte colony-stimulating factor, and other growth factors. It also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2, It activates a signaling cascade that promotes cell proliferation. | |||
| M55631
|
Recombinant Human IL-7 Protein (E. coli) | 重组人白介素7/IL-7蛋白 (E. coli) | Cytokines and Growth Factors |
| Interleukin-7; IL7 | |||
| Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction. | |||
| M55632
|
Recombinant Human IL-7 Protein (HEK293, C-6His) | 重组人白介素7/IL-7蛋白 (HEK293, C-6His) | Cytokines and Growth Factors |
| Interleukin-7; IL7 | |||
| Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL-7 signals via IL-7 receptor (IL7R) activating multiple pathways including JaK/STAT and PI3K/AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction. | |||
